hydralazine has been researched along with Aging in 28 studies
Hydralazine: A direct-acting vasodilator that is used as an antihypertensive agent.
hydralazine : The 1-hydrazino derivative of phthalazine; a direct-acting vasodilator that is used as an antihypertensive agent.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fixed-dose combined isosorbide dinitrate/hydralazine (FDC I/H) significantly improved outcomes in patients with advanced heart failure (HF) receiving background neurohormonal therapy in the African-American Heart Failure Trial (A-HeFT)." | 9.16 | Effect of fixed-dose combined isosorbide dinitrate/hydralazine in elderly patients in the African-American heart failure trial. ( Archambault, WT; Cohn, JN; Ghali, JK; Sabolinski, ML; Tam, SW; Taylor, AL; Worcel, M; Ziesche, S, 2012) |
| "Thus, flow remodelling in resistance arteries failed to occur in aging but it could be restored by hydralazine via a reactive oxygen species-dependent mechanism." | 7.74 | Alteration in flow (shear stress)-induced remodelling in rat resistance arteries with aging: improvement by a treatment with hydralazine. ( Baufreton, C; Dumont, O; Guihot, AL; Henrion, D; Loufrani, L; Pinaud, F, 2008) |
| "In order to study the role of elastin in arteries with respect to hypertension and hypertensive arterial disease, aortic elastin content and elastase-like enzyme activity were examined and compared in stroke-prone spontaneously hypertensive rats (SHRSP), which show malignant hypertension, and Wistar-Kyoto normotensive rats (WKY)." | 7.67 | Elastin and elastase-like enzyme change in aorta of rat with malignant hypertension. ( Daniel, EE; Ito, H; Kwan, CY, 1987) |
| "Fixed-dose combined isosorbide dinitrate/hydralazine (FDC I/H) significantly improved outcomes in patients with advanced heart failure (HF) receiving background neurohormonal therapy in the African-American Heart Failure Trial (A-HeFT)." | 5.16 | Effect of fixed-dose combined isosorbide dinitrate/hydralazine in elderly patients in the African-American heart failure trial. ( Archambault, WT; Cohn, JN; Ghali, JK; Sabolinski, ML; Tam, SW; Taylor, AL; Worcel, M; Ziesche, S, 2012) |
| "In order to study the role of elastin in arteries with respect to hypertension and hypertensive arterial disease, aortic elastin content and elastase-like enzyme activity were examined and compared in stroke-prone spontaneously hypertensive rats (SHRSP), which show malignant hypertension, and Wistar-Kyoto normotensive rats (WKY)." | 3.67 | Elastin and elastase-like enzyme change in aorta of rat with malignant hypertension. ( Daniel, EE; Ito, H; Kwan, CY, 1987) |
| "Hydralazine is an FDA-approved drug used in the treatment of hypertension, heart failure and cancer." | 1.51 | Hydralazine targets cAMP-dependent protein kinase leading to sirtuin1/5 activation and lifespan extension in C. elegans. ( Dehghan, E; Goodarzi, M; Lin, R; Mirzaei, H; Saremi, B, 2019) |
| "Hydralazine treatment resulted in a threefold increase in tropoelastin mRNA levels in both the SHR and the WKY animals (P less than 0." | 1.28 | Changes in aortic levels of tropoelastin mRNA following treatment of rats with the antihypertensive drugs captopril and hydralazine. ( Alden, SM; Boyd, CD; Deak, SB; Mackenzie, JW; Pierce, RA; Tozzi, CA, 1991) |
| "Hydralazine treatment, which prevented the development of hypertension, attenuated the increased 3H overflow evoked by PNS in SHR." | 1.28 | Effect of chronically administered hydralazine on altered adrenergic neurotransmission mediated by presynaptic alpha- and beta-adrenoceptors in spontaneously hypertensive rats. ( Kato, H; Mochizuki, S; Takata, Y, 1990) |
| "Phentolamine (10(-6) M) pretreatment had no effect on the ouabain-induced contraction but partially suppressed it in both SHR and WKY aortas when diltiazem (10(-5) M) was also added." | 1.27 | Ouabain-induced contraction of vascular smooth muscle in spontaneously hypertensive rats and the effect of hydralazine. ( Iwasaki, T; Kawai, Y; Miyata, S; Morita, S; Nagai, K, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (28.57) | 18.7374 |
| 1990's | 8 (28.57) | 18.2507 |
| 2000's | 10 (35.71) | 29.6817 |
| 2010's | 2 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dehghan, E | 1 |
| Goodarzi, M | 1 |
| Saremi, B | 1 |
| Lin, R | 1 |
| Mirzaei, H | 1 |
| Taylor, AL | 1 |
| Sabolinski, ML | 1 |
| Tam, SW | 1 |
| Ziesche, S | 1 |
| Ghali, JK | 1 |
| Archambault, WT | 1 |
| Worcel, M | 1 |
| Cohn, JN | 1 |
| FREIS, ED | 2 |
| Hobara, N | 1 |
| Gessei-Tsutsumi, N | 1 |
| Goda, M | 1 |
| Takayama, F | 1 |
| Akiyama, S | 1 |
| Kurosaki, Y | 1 |
| Kawasaki, H | 1 |
| Demirci, B | 1 |
| McKeown, PP | 1 |
| Bayraktutan, U | 1 |
| Hannan, JL | 1 |
| Smallegange, C | 1 |
| Hale, TM | 1 |
| Heaton, JP | 1 |
| Adams, MA | 1 |
| Baumann, M | 1 |
| Janssen, BJ | 1 |
| Hermans, JJ | 1 |
| Peutz-Kootstra, C | 1 |
| Witzke, O | 1 |
| Smits, JF | 1 |
| Struijker Boudier, HA | 1 |
| Pinaud, F | 2 |
| Bocquet, A | 1 |
| Dumont, O | 2 |
| Retailleau, K | 1 |
| Baufreton, C | 2 |
| Andriantsitohaina, R | 1 |
| Loufrani, L | 2 |
| Henrion, D | 2 |
| Guihot, AL | 1 |
| Pulliam, JP | 1 |
| McCarron, DA | 1 |
| Ljungman, S | 1 |
| Wikstrand, J | 1 |
| Hartford, M | 1 |
| Aurell, M | 1 |
| Lindstedt, G | 1 |
| Berglund, G | 1 |
| Traub, O | 1 |
| Lloyd, MC | 1 |
| Webb, RC | 1 |
| Shimamura, K | 1 |
| Matsuda, K | 1 |
| Sekiguchi, F | 1 |
| Sunano, S | 1 |
| Casellas, D | 1 |
| Bouriquet, N | 1 |
| Artuso, A | 1 |
| Goto, K | 1 |
| Fujii, K | 1 |
| Onaka, U | 1 |
| Abe, I | 1 |
| Fujishima, M | 1 |
| Aronow, WS | 1 |
| Blumberg, MS | 1 |
| Sokoloff, G | 1 |
| Kirby, RF | 1 |
| Knoot, TG | 1 |
| Lewis, SJ | 1 |
| Weiss, LR | 1 |
| Krop, S | 1 |
| Li, SJ | 1 |
| Wong, SC | 1 |
| Hong, JS | 1 |
| Ingenito, AJ | 1 |
| Kimura, K | 1 |
| Tojo, A | 1 |
| Matsuoka, H | 1 |
| Sugimoto, T | 1 |
| Alden, SM | 1 |
| Pierce, RA | 1 |
| Tozzi, CA | 1 |
| Mackenzie, JW | 1 |
| Deak, SB | 1 |
| Boyd, CD | 1 |
| Takata, Y | 1 |
| Mochizuki, S | 1 |
| Kato, H | 1 |
| Hanton, G | 1 |
| Longeart, L | 1 |
| Lodola, A | 1 |
| Michel, JB | 1 |
| Azizi, M | 1 |
| Salzmann, JL | 1 |
| Levy, B | 1 |
| Ménard, J | 1 |
| Morita, S | 1 |
| Iwasaki, T | 1 |
| Nagai, K | 1 |
| Miyata, S | 1 |
| Kawai, Y | 1 |
| Ito, H | 1 |
| Kwan, CY | 1 |
| Daniel, EE | 1 |
| Simpson, LL | 1 |
| Ragan, D | 1 |
| Pillsbury, H | 1 |
| Mathews, M | 1 |
1 review available for hydralazine and Aging
| Article | Year |
|---|---|
Left ventricular diastolic heart failure with normal left ventricular systolic function in older persons.
Topics: Adrenergic beta-Antagonists; Aged; Aging; Angiotensin Receptor Antagonists; Angiotensin-Converting E | 2001 |
1 trial available for hydralazine and Aging
| Article | Year |
|---|---|
Effect of fixed-dose combined isosorbide dinitrate/hydralazine in elderly patients in the African-American heart failure trial.
Topics: Age Factors; Aged; Aging; Black or African American; Double-Blind Method; Drug Therapy, Combination; | 2012 |
26 other studies available for hydralazine and Aging
| Article | Year |
|---|---|
Hydralazine targets cAMP-dependent protein kinase leading to sirtuin1/5 activation and lifespan extension in C. elegans.
Topics: Aging; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cyclic AMP; Cyclic AMP-Depe | 2019 |
OFFICE EVALUATION OF THE HYPERTENSIVE PATIENT. II.
Topics: Aging; Blood Pressure; Blood Pressure Determination; Central Nervous System; Diuretics; Fundus Oculi | 1963 |
Long-term inhibition of angiotensin prevents reduction of periarterial innervation of calcitonin gene-related peptide (CGRP)-containing nerves in spontaneously hypertensive rats.
Topics: Aging; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; C | 2005 |
Blockade of angiotensin II provides additional benefits in hypertension- and ageing-related cardiac and vascular dysfunctions beyond its blood pressure-lowering effects.
Topics: Aging; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Aorta, Thoracic; B | 2005 |
Impact of antihypertensive treatments on erectile responses in aging spontaneously hypertensive rats.
Topics: Aging; Animals; Antihypertensive Agents; Apomorphine; Blood Pressure; Enalapril; Hydralazine; Hydroc | 2006 |
Transient AT1 receptor-inhibition in prehypertensive spontaneously hypertensive rats results in maintained cardiac protection until advanced age.
Topics: Age Factors; Aging; Albuminuria; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; C | 2007 |
Paradoxical role of angiotensin II type 2 receptors in resistance arteries of old rats.
Topics: Aging; Animals; Endothelial Cells; Hydralazine; In Vitro Techniques; Male; Mesenteric Arteries; Musc | 2007 |
Alteration in flow (shear stress)-induced remodelling in rat resistance arteries with aging: improvement by a treatment with hydralazine.
Topics: Aging; Animals; Hydralazine; Male; Mesenteric Arteries; Nitric Oxide; Nitric Oxide Synthase Type III | 2008 |
Hypertension: special concerns in geriatric patients.
Topics: Adrenergic beta-Antagonists; Aged; Aging; Calcium Channel Blockers; Captopril; Diet, Sodium-Restrict | 1984 |
Effects of long-term antihypertensive treatment and aging on renal function and albumin excretion in primary hypertension.
Topics: Aging; Albuminuria; Case-Control Studies; Drug Therapy, Combination; Follow-Up Studies; Glomerular F | 1993 |
Long-term effects of brief antihypertensive treatment on systolic blood pressure and vascular reactivity in young genetically hypertensive rats.
Topics: Aging; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; B | 1995 |
Blood pressure and age-dependent changes of endothelium-dependent tension oscillations in different strains of spontaneously hypertensive rats.
Topics: Acetylcholine; Aging; Animals; Antihypertensive Agents; Aorta; Blood Pressure; Captopril; Endotheliu | 1996 |
Nitric oxide and preglomerular vascular lesions in lyon spontaneously hypertensive rats.
Topics: Aging; Animals; Antihypertensive Agents; Azo Compounds; Coloring Agents; Drug Combinations; Enzyme I | 2000 |
Angiotensin-converting enzyme inhibitor prevents age-related endothelial dysfunction.
Topics: Acetylcholine; Administration, Oral; Aging; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors | 2000 |
Effects of antihypertensive drugs on ultrasound production and cardiovascular responses in 15-day-old rats.
Topics: Aging; Animals; Antihypertensive Agents; Blood Pressure; Chlorisondamine; Cold Temperature; Female; | 2002 |
Advanced age as a factor in the response of rodents to drugs [proceedings].
Topics: Aging; Animals; Cricetinae; Female; Hexobarbital; Hydralazine; Isoproterenol; Male; Mesocricetus; Mi | 1978 |
Age-related changes in opioid peptide concentrations in brain and pituitary of spontaneously hypertensive rats. Effect of antihypertensive drugs and comparison with deoxycorticosterone acetate and salt hypertension.
Topics: Aging; Animals; beta-Endorphin; Brain; Desoxycorticosterone; Dynorphins; Endorphins; Enkephalin, Met | 1992 |
Renal arteriolar diameters in spontaneously hypertensive rats. Vascular cast study.
Topics: Aging; Animals; Arterioles; Blood Pressure; Body Weight; Captopril; Hydralazine; Hypertension; Kidne | 1991 |
Changes in aortic levels of tropoelastin mRNA following treatment of rats with the antihypertensive drugs captopril and hydralazine.
Topics: Aging; Animals; Antihypertensive Agents; Aorta; Blood Pressure; Captopril; Hydralazine; Nucleic Acid | 1991 |
Effect of chronically administered hydralazine on altered adrenergic neurotransmission mediated by presynaptic alpha- and beta-adrenoceptors in spontaneously hypertensive rats.
Topics: Adrenergic Fibers; Aging; Animals; Blood Pressure; Drug Administration Schedule; Electric Stimulatio | 1990 |
Cardiotoxicity of hydralazine and minoxidil in the rat. Influence of age.
Topics: Aging; Animals; Blood Pressure; Heart Diseases; Heart Rate; Hydralazine; Isoproterenol; Minoxidil; M | 1991 |
Effect of vasodilatators on the structure of the aorta in normotensive ageing rats.
Topics: Aging; Animals; Aorta; Arteries; Blood Pressure; Collagen; Dihydralazine; Elastin; Enalapril; Hydral | 1987 |
Ouabain-induced contraction of vascular smooth muscle in spontaneously hypertensive rats and the effect of hydralazine.
Topics: Aging; Animals; Blood Pressure; Body Weight; Calcium; Calcium Radioisotopes; Hydralazine; Hypertensi | 1988 |
Elastin and elastase-like enzyme change in aorta of rat with malignant hypertension.
Topics: Aging; Animals; Aorta; Blood Pressure; Cell Membrane; Elastin; Hydralazine; Hypertension, Malignant; | 1987 |
The effect of prostaglandin E2 on the arterial blood pressure of normotensive and spontaneously hypertensive rats.
Topics: Acetylcholine; Aging; Animals; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, | 1974 |
Alteration of the course of hypertension in the spontaneously hypertensive rat.
Topics: Aging; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Chlorothiazide; Environment; E | 1972 |