hydralazine has been researched along with Adenocarcinoma in 13 studies
Hydralazine: A direct-acting vasodilator that is used as an antihypertensive agent.
hydralazine : The 1-hydrazino derivative of phthalazine; a direct-acting vasodilator that is used as an antihypertensive agent.
Adenocarcinoma: A malignant epithelial tumor with a glandular organization.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have studied the influence of the peripheral vasodilator hydralazine (HDZ) on the vasculature and blood perfusion of two members of a series of subcutaneous murine adenocarcinomata of the colon (MAC tumours), and the influence of HDZ on the efficacy and/or toxicity of TCNU and melphalan." | 3.68 | The influence of hydralazine on the vasculature, blood perfusion and chemosensitivity of MAC tumours. ( Bibby, MC; Cox, JA; Crawford, SM; Quinn, PK, 1992) |
| "The effects of hydralazine on the blood flow in various normal tissues and R3230 Ac adenocarcinomas grown in different sites in rats were studied." | 3.68 | Effect of hydralazine on the blood flow in tumors and normal tissues in rats. ( Hasegawa, T; Song, CW, 1991) |
| " By simultaneously monitoring the effects in various tissues, the pharmacokinetic effect of each drug in the entire body could be obtained." | 1.29 | Pharmacokinetic changes induced by vasomodulators in kidneys, livers, muscles, and implanted tumors in rats as measured by dynamic Gd-DTPA-enhanced MRI. ( Lao, X; Nalcioglu, O; Roth, GM; Samoszuk, MK; Su, MY; Wang, Z, 1996) |
| "Hydralazine and isoniazid were also tested by the subcutaneous (sc) route at weekly dosages of 17 and 83 mg/kg, respectively, in both intact and partially hepatectomized rats, but many succumbed after 7 to 49 weeks of treatment." | 1.28 | Action of hydrazine drugs in tumor-free and 1,2-dimethylhydrazine-treated male rats. ( Gershbein, LL; Rao, KC, 1992) |
| "When hydralazine was given 40 min after a dose of 800 mg/kg of MISO, without X-rays, growth delays in excess of 5 tumour volume doubling times resulted and fewer tumour cells were present in histological sections." | 1.28 | Manipulation of oxygenation in a human tumour xenograft with BW12C or hydralazine: effects on responses to radiation and to the bioreductive cytotoxicity of misonidazole or RSU-1069. ( Cole, S; Robbins, L, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (23.08) | 18.7374 |
| 1990's | 8 (61.54) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bailey, KM | 1 |
| Cornnell, HH | 1 |
| Ibrahim-Hashim, A | 1 |
| Wojtkowiak, JW | 1 |
| Hart, CP | 1 |
| Zhang, X | 1 |
| Leos, R | 1 |
| Martinez, GV | 1 |
| Baker, AF | 1 |
| Gillies, RJ | 1 |
| Cowen, SE | 1 |
| Bibby, MC | 4 |
| Double, JA | 3 |
| Sleigh, NR | 1 |
| Loadman, PM | 2 |
| Horsman, MR | 1 |
| Nordsmark, M | 1 |
| Høyer, M | 1 |
| Overgaard, J | 1 |
| Su, MY | 2 |
| Wang, Z | 2 |
| Roth, GM | 1 |
| Lao, X | 1 |
| Samoszuk, MK | 1 |
| Nalcioglu, O | 2 |
| Najafi, A | 1 |
| Toth, B | 1 |
| Quinn, PK | 1 |
| Cox, JA | 1 |
| Crawford, SM | 1 |
| al-Ghabban, AF | 1 |
| Gershbein, LL | 1 |
| Rao, KC | 1 |
| Hasegawa, T | 1 |
| Song, CW | 1 |
| Cole, S | 1 |
| Robbins, L | 1 |
| Drozdz, M | 1 |
| Luciak, M | 1 |
| Jendryczko, A | 1 |
| Magner, K | 1 |
13 other studies available for hydralazine and Adenocarcinoma
| Article | Year |
|---|---|
Evaluation of the "steal" phenomenon on the efficacy of hypoxia activated prodrug TH-302 in pancreatic cancer.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Blood Circulation; Cell Hypoxia; Cell Line, Tumor; D | 2014 |
Characterisation of the vasculature within a murine adenocarcinoma growing in different sites to evaluate the potential of vascular therapies.
Topics: Adenocarcinoma; Animals; Benzimidazoles; Cecal Neoplasms; Colonic Neoplasms; Fluorescent Dyes; Human | 1995 |
Potentiation of EO9 anti-tumour activity by hydralazine.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Aziridines; Bone Marrow; Colony-Forming Units Assay; | 1993 |
Direct evidence that hydralazine can induce hypoxia in both transplanted and spontaneous murine tumours.
Topics: Adenocarcinoma; Animals; Cell Hypoxia; Electrodes; Female; Hydralazine; Male; Mammary Neoplasms, Exp | 1995 |
Pharmacokinetic changes induced by vasomodulators in kidneys, livers, muscles, and implanted tumors in rats as measured by dynamic Gd-DTPA-enhanced MRI.
Topics: Adenocarcinoma; Angiotensin II; Animals; Blood Flow Velocity; Capillary Permeability; Cell Transplan | 1996 |
Effect of vasodilator hydralazine on tumor microvascular random flow and blood volume as measured by intravoxel incoherent motion (IVIM) weighted MRI in conjunction with Gd-DTPA-Albumin enhanced MRI.
Topics: Adenocarcinoma; Albumins; Animals; Blood Flow Velocity; Blood Volume; Contrast Media; Female; Gadoli | 2001 |
Tumorigenic effect of 1-hydrazinophthalazine hydrochloride in mice.
Topics: Adenocarcinoma; Adenoma; Animals; Female; Humans; Hydralazine; Lung Neoplasms; Male; Mice; Neoplasms | 1978 |
The influence of hydralazine on the vasculature, blood perfusion and chemosensitivity of MAC tumours.
Topics: Adenocarcinoma; Animals; Bone Marrow; Cell Division; Cell Line; Colonic Neoplasms; Hydralazine; Male | 1992 |
Influence of hydralazine on the pharmacokinetics of tauromustine (TCNU) in mice.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Dose-Response | 1992 |
Action of hydrazine drugs in tumor-free and 1,2-dimethylhydrazine-treated male rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Administration, Oral; Animals; Carcinogens; Colonic Neoplasms | 1992 |
Effect of hydralazine on the blood flow in tumors and normal tissues in rats.
Topics: Adenocarcinoma; Animals; Blood Circulation; Cardiac Output; Depression, Chemical; Hydralazine; Male; | 1991 |
Manipulation of oxygenation in a human tumour xenograft with BW12C or hydralazine: effects on responses to radiation and to the bioreductive cytotoxicity of misonidazole or RSU-1069.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Benzaldehydes; Colonic Neop | 1989 |
Changes in lung activity of superoxide dismutase and copper concentration during lung tumorigenesis by hydralazine in Swiss mice.
Topics: Adenocarcinoma; Adenoma; Animals; Carcinogens; Copper; Hydralazine; Lung; Lung Neoplasms; Mice; Sex | 1987 |