Compounds > hydralazine
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hydralazine and Acute Liver Injury, Drug-Induced

hydralazine has been researched along with Acute Liver Injury, Drug-Induced in 42 studies

Hydralazine: A direct-acting vasodilator that is used as an antihypertensive agent.
hydralazine : The 1-hydrazino derivative of phthalazine; a direct-acting vasodilator that is used as an antihypertensive agent.

Research Excerpts

ExcerptRelevanceReference
"A hepatitis with bridging necrosis following dihydralazine therapy has been diagnosed bioptically in 20 cases, preferably in women."7.66[Dihydralazine-induced hepatitis with bridging necrosis. A clinico-pathologic survey of 20 cases]. ( Roschlau, G, 1983)
"Three cases with drug-induced liver diseases (hepatitis caused by hydralasine, steatosis caused by methimazole, choletasis caused by birth control pill) were investigated with respect to their drug metabolising ability."3.67Drug metabolism in drug-induced liver diseases: pathogenetic role of active metabolites. ( Hoffmann-Traeger, A; Horváth, T; Jávor, T; Kádas, I; Németh, A; Past, T; Rechenbach, C, 1989)
"Liver injuries following application of dihydralazine in 14 patients, ten of them with the typical pattern of perivenous liver cell necrosis, are reported."3.67[The so-called dihydralazine hepatitis. A contribution to the pathogenesis]. ( Jahn, G; Krombholz, B; Machnik, G; Reinhardt, M, 1985)
"A hepatitis with bridging necrosis following dihydralazine therapy has been diagnosed bioptically in 20 cases, preferably in women."3.66[Dihydralazine-induced hepatitis with bridging necrosis. A clinico-pathologic survey of 20 cases]. ( Roschlau, G, 1983)
"Three patients developed hepatic injury two months, ten months and two years, respectively, after hydralazine therapy for hypertension."3.66Hydralazine-induced hepatitis. ( Ichinoe, A; Itoh, S; Itoh, Y; Tsukada, Y, 1981)
"Like idiopathic autoimmune hepatitis, circulating autoantibodies and a hypergammaglobulinemia are frequently present in sera from patients with AI-DILI."2.50Drug-induced liver injury with autoimmune features. ( Ahrens, W; Bonkovsky, HL; deLemos, AS; Foureau, DM; Jacobs, C; Russo, MW, 2014)
"Antihypertensive agents have been associated with adverse reactions that, if unrecognized by health practitioners, may have devastating consequences."2.38Fatal hepatotoxicity induced by hydralazine or labetalol. ( Stumpf, JL, 1991)
"Hydralazineinduced acute liver failure is extremely rare."1.91Hydralazine-Induced Fulminant Liver Failure Requiring Urgent Liver Transplant: Common Drug With Rare Complication. ( Barritt, AS; de Oliveira, GC; Desai, CS; Kumar, A; Szempruch, KR; Zendel, A, 2023)
"Hydralazine is a commonly prescribed antihypertensive agent."1.62Hydralazine-induced liver injury: a review and discussion. ( Bhardwaj, M; Bhardwaj, NJ; Cueto, K; Killeen, TC, 2021)
"Hepatitis was severe with hepatic encephalopathy and prolonged prothrombin time."1.27Dihydralazine hepatitis: report of a case and review of the literature. ( Benhamou, JP; Bernuau, J; Degott, C; Pariente, EA; Pessayre, D, 1983)

Research

Studies (42)

TimeframeStudies, this research(%)All Research%
pre-199031 (73.81)18.7374
1990's2 (4.76)18.2507
2000's0 (0.00)29.6817
2010's7 (16.67)24.3611
2020's2 (4.76)2.80

Authors

AuthorsStudies
Fourches, D1
Barnes, JC1
Day, NC1
Bradley, P1
Reed, JZ1
Tropsha, A1
Liu, Z1
Shi, Q1
Ding, D1
Kelly, R1
Fang, H1
Tong, W2
Sakatis, MZ1
Reese, MJ1
Harrell, AW1
Taylor, MA1
Baines, IA1
Chen, L1
Bloomer, JC1
Yang, EY1
Ellens, HM1
Ambroso, JL1
Lovatt, CA1
Ayrton, AD1
Clarke, SE1
Warner, DJ1
Chen, H1
Cantin, LD1
Kenna, JG1
Stahl, S1
Walker, CL1
Noeske, T1
Chen, M1
Suzuki, A1
Thakkar, S1
Yu, K1
Hu, C1
de Oliveira, GC1
Kumar, A1
Szempruch, KR1
Barritt, AS1
Zendel, A1
Desai, CS1
Bhardwaj, M1
Bhardwaj, NJ1
Cueto, K1
Killeen, TC1
Sharma, M1
Foge, M1
Mascarenhas, D1
deLemos, AS1
Foureau, DM1
Jacobs, C1
Ahrens, W1
Russo, MW1
Bonkovsky, HL1
MOYER, JH1
HANDLEY, CA1
Myers, JL1
Augur, NA1
Hod, M2
Friedman, S2
Theodor, E1
Ovadia, J2
Rice, D1
Burdick, CO1
Roschlau, G3
Pariente, EA1
Pessayre, D1
Bernuau, J1
Degott, C1
Benhamou, JP1
Itoh, S2
Ichinoe, A2
Tsukada, Y2
Itoh, Y1
Kendrey, G2
László, B2
Forster, HS1
Barnett, DB1
Hudson, SA1
Golightly, PW1
Mölleken, K1
Rüger, K1
Yamaba, Y1
Drayer, DE1
Reidenberg, MM1
Olsson, R1
Bartoli, E1
Massarelli, G1
Solinas, A1
Faedda, R1
Chiandussi, L1
Knoblauch, M1
Cueni, B1
Spycher, M1
Schmid, M1
Stumpf, JL1
Baumgarten, R2
Fengler, JD2
Horváth, T1
Past, T1
Németh, A1
Kádas, I1
Hoffmann-Traeger, A1
Rechenbach, C2
Jávor, T1
Siegmund, W1
Franke, G1
Krüger, R1
Reichardt, R1
Hoffmann, A1
Reinhardt, M3
Henschel, L1
Jorke, D1
Colombel, JF1
Cortot, A1
Houcke, M1
Prin, L1
Dessaint, JP1
Gerard, A1
Paris, JC1
Hass, S1
Schmehl, V1
Machnik, G2
Bergert, A1
Justus, J1
Kunze, P1
Müller, R1
Schulz, H1
Stein, G1
Thiele, R1
Kunze, KD2
Porst, H2
Tschöpel, L2
Lohmann, J1
Kantola, I1
Viikari, J1
Leino, R1
Seppälä, P1
Krombholz, B1
Jahn, G1
Jori, GP1
Peschile, C1
Sotaniemi, E1
Hokkanen, O1
Kaipainen, WJ1

Reviews

4 reviews available for hydralazine and Acute Liver Injury, Drug-Induced

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr

2016
A Suspected Case of Hydralazine-Induced Hepatotoxicity: A Case Report and Review of Literature.
    The American journal of case reports, 2018, Jul-07, Volume: 19

    Topics: Aged; Antihypertensive Agents; Chemical and Drug Induced Liver Injury; Humans; Hydralazine; Hyperten

2018
Drug-induced liver injury with autoimmune features.
    Seminars in liver disease, 2014, Volume: 34, Issue:2

    Topics: Adult; Anti-Bacterial Agents; Anti-Infective Agents, Urinary; Antihypertensive Agents; Autoantibodie

2014
Fatal hepatotoxicity induced by hydralazine or labetalol.
    Pharmacotherapy, 1991, Volume: 11, Issue:5

    Topics: Aged; Chemical and Drug Induced Liver Injury; Humans; Hydralazine; Hypertension; Labetalol; Male

1991

Other Studies

38 other studies available for hydralazine and Acute Liver Injury, Drug-Induced

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI

2010
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
    PLoS computational biology, 2011, Volume: 7, Issue:12

    Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da

2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters

2012
Hydralazine-Induced Fulminant Liver Failure Requiring Urgent Liver Transplant: Common Drug With Rare Complication.
    Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation, 2023, Volume: 21, Issue:1

    Topics: Aged; Chemical and Drug Induced Liver Injury; Female; Humans; Hydralazine; Liver Failure, Acute; Liv

2023
Hydralazine-induced liver injury: a review and discussion.
    BMJ case reports, 2021, Aug-17, Volume: 14, Issue:8

    Topics: Antihypertensive Agents; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inj

2021
Renal function and systemic blood pressure changes following the administration of hydrazinophthalazine.
    The Journal of laboratory and clinical medicine, 1950, Volume: 36, Issue:6

    Topics: Blood Pressure; Chemical and Drug Induced Liver Injury; Humans; Hydralazine; Hydrazines; Liver; Phar

1950
Hydralazine-induced cholangitis.
    Gastroenterology, 1984, Volume: 87, Issue:5

    Topics: Acute Disease; Chemical and Drug Induced Liver Injury; Cholangitis; Cholecystitis; Female; Humans; H

1984
[Acute liver disease during treatment of severe preeclampsia].
    Harefuah, 1983, May-01, Volume: 104, Issue:9

    Topics: Acute Disease; Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Hydralazine; Liver Dis

1983
Granulomatous hepatitis from hydralazine therapy.
    Archives of internal medicine, 1983, Volume: 143, Issue:5

    Topics: Chemical and Drug Induced Liver Injury; Female; Humans; Hydralazine; Middle Aged

1983
Severe consequence of hypertension in pregnancy.
    American journal of obstetrics and gynecology, 1983, Jan-01, Volume: 145, Issue:1

    Topics: Chemical and Drug Induced Liver Injury; Female; Humans; Hydralazine; Hypertension; Pre-Eclampsia; Pr

1983
[Dihydralazine-induced hepatitis with bridging necrosis. A clinico-pathologic survey of 20 cases].
    Zentralblatt fur allgemeine Pathologie u. pathologische Anatomie, 1983, Volume: 127, Issue:5-6

    Topics: Adolescent; Adult; Aged; Biopsy; Chemical and Drug Induced Liver Injury; Dihydralazine; Female; Huma

1983
Dihydralazine hepatitis: report of a case and review of the literature.
    Digestion, 1983, Volume: 27, Issue:1

    Topics: Biopsy; Chemical and Drug Induced Liver Injury; Dihydralazine; Hepatic Encephalopathy; Humans; Hydra

1983
Hydralazine-induced hepatitis.
    Hepato-gastroenterology, 1981, Volume: 28, Issue:1

    Topics: Chemical and Drug Induced Liver Injury; Female; Humans; Hydralazine; Hypertension; Liver; Liver Cirr

1981
[Morphologic observations in liver damage in patients taking Depressan (dihydralazinum sulfuricum)].
    Morphologiai es igazsagugyi orvosi szemle, 1981, Volume: 21, Issue:4

    Topics: Antihypertensive Agents; Biopsy, Needle; Chemical and Drug Induced Liver Injury; Dihydralazine; Huma

1981
[Acute liver damage in patients treated with a depressant (dihydralazine sulfate)].
    Orvosi hetilap, 1981, Dec-27, Volume: 122, Issue:52

    Topics: Acute Disease; Aged; Chemical and Drug Induced Liver Injury; Dihydralazine; Female; Humans; Hydralaz

1981
Hepatitis from hydralazine.
    The New England journal of medicine, 1980, Jun-12, Volume: 302, Issue:24

    Topics: Adult; Chemical and Drug Induced Liver Injury; Humans; Hydralazine; Male

1980
Hydrallazine-induced hepatitis?
    British medical journal, 1980, May-10, Volume: 280, Issue:6224

    Topics: Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Hydralazine; Hypertension; Liver Func

1980
[Rare liver damage caused by an antihypertensive and anti-arrhythmic agents].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1980, Apr-01, Volume: 35, Issue:7

    Topics: Adult; Ajmaline; Biopsy; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Dihydral

1980
Hydralazine-induced liver injury.
    Digestive diseases and sciences, 1980, Volume: 25, Issue:11

    Topics: Aged; Chemical and Drug Induced Liver Injury; Humans; Hydralazine; Liver; Liver Function Tests; Male

1980
Clinical consequences of polymorphic acetylation of basic drugs.
    Clinical pharmacology and therapeutics, 1977, Volume: 22, Issue:3

    Topics: Acetylation; Antibodies, Antinuclear; Biotransformation; Chemical and Drug Induced Liver Injury; Hum

1977
Liver damage due to antihypertensive drugs.
    Acta medica Scandinavica. Supplementum, 1979, Volume: 628

    Topics: Antihypertensive Agents; Benzothiadiazines; Chemical and Drug Induced Liver Injury; Diuretics; Femal

1979
Acute hepatitis with bridging necrosis due to hydralazine intake. Report of a case.
    Archives of internal medicine, 1979, Volume: 139, Issue:6

    Topics: Acute Disease; Chemical and Drug Induced Liver Injury; Female; Humans; Hydralazine; Liver; Middle Ag

1979
[Dihydralazine-induced hepatitis].
    Schweizerische medizinische Wochenschrift, 1977, May-14, Volume: 107, Issue:19

    Topics: Chemical and Drug Induced Liver Injury; Dihydralazine; Humans; Hydralazine; Hypertension; Lupus Eryt

1977
[Dihydralazine-induced acute hepatitis with IgM deficiency].
    Schweizerische medizinische Wochenschrift, 1977, May-14, Volume: 107, Issue:19

    Topics: Acetylation; Aged; Antibodies; Chemical and Drug Induced Liver Injury; Dihydralazine; Drug Hypersens

1977
[Dihydralazine hepatitis. Morphologic and clinical criteria for diagnosis].
    Zentralblatt fur allgemeine Pathologie u. pathologische Anatomie, 1990, Volume: 136, Issue:1-2

    Topics: Acute Disease; Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Diagnosis, Different

1990
Drug metabolism in drug-induced liver diseases: pathogenetic role of active metabolites.
    Acta physiologica Hungarica, 1989, Volume: 73, Issue:2-3

    Topics: Adult; Aged; Biotransformation; Chemical and Drug Induced Liver Injury; Contraceptives, Oral, Combin

1989
Kinetics of antipyrine and sulfamethazine in patients recovered from dihydralazine-hepatitis.
    International journal of clinical pharmacology, therapy, and toxicology, 1989, Volume: 27, Issue:4

    Topics: Acetylation; Adult; Aged; Antipyrine; Chemical and Drug Induced Liver Injury; Dihydralazine; Female;

1989
[Biotransformation in patients following Depressan-induced hepatitis].
    Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR, 1989, Volume: 49, Issue:1

    Topics: Adult; Aged; Biotransformation; Caffeine; Chemical and Drug Induced Liver Injury; Dihydralazine; Fem

1989
[Dihydralazine hepatitis].
    Presse medicale (Paris, France : 1983), 1985, Mar-02, Volume: 14, Issue:9

    Topics: Chemical and Drug Induced Liver Injury; Dihydralazine; Humans; Hydralazine; Middle Aged

1985
[Chronic drug-induced hepatitis caused by dihydralazine].
    Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten, 1988, Volume: 48, Issue:1

    Topics: Aged; Biopsy, Needle; Chemical and Drug Induced Liver Injury; Chronic Disease; Dihydralazine; Female

1988
[Drug-induced hepatitis after dihydralazine treatment with fatal consequences].
    Zentralblatt fur allgemeine Pathologie u. pathologische Anatomie, 1988, Volume: 134, Issue:2

    Topics: Aged; Chemical and Drug Induced Liver Injury; Dihydralazine; Female; Humans; Hydralazine; Liver; Mal

1988
[Morphology and pathogenesis of liver injury produced by dihydralazine , propranolol and ketophenylbutazone].
    Zentralblatt fur allgemeine Pathologie u. pathologische Anatomie, 1985, Volume: 130, Issue:6

    Topics: Chemical and Drug Induced Liver Injury; Dihydralazine; Humans; Hydralazine; Immunity, Cellular; Live

1985
[Liver lesions induced by dihydralazine and propranolol].
    Zentralblatt fur allgemeine Pathologie u. pathologische Anatomie, 1985, Volume: 130, Issue:1

    Topics: Biopsy; Chemical and Drug Induced Liver Injury; Cholangitis; Dihydralazine; Female; Humans; Hydralaz

1985
[Drug-induced hepatitis in a diabetic patient].
    Duodecim; laaketieteellinen aikakauskirja, 1985, Volume: 101, Issue:6

    Topics: Adult; Chemical and Drug Induced Liver Injury; Diabetes Mellitus, Type 1; Dihydralazine; Humans; Hyd

1985
[The so-called dihydralazine hepatitis. A contribution to the pathogenesis].
    Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten, 1985, Volume: 45, Issue:6

    Topics: Adult; Aged; Biopsy; Chemical and Drug Induced Liver Injury; Dihydralazine; Drug Therapy, Combinatio

1985
Hydralazine disease associated with transient granulomas in the liver. A case report.
    Gastroenterology, 1973, Volume: 64, Issue:6

    Topics: Biopsy; Chemical and Drug Induced Liver Injury; Female; Granuloma; Humans; Hydralazine; Hypertension

1973
Hepatic injury and multiple drug treatment.
    Annals of clinical research, 1971, Volume: 3, Issue:4

    Topics: Adult; Bilirubin; Chemical and Drug Induced Liver Injury; Contraceptives, Oral; Drug Interactions; D

1971