hydnocarpin has been researched along with Precursor-Cell-Lymphoblastic-Leukemia-Lymphoma* in 2 studies
2 other study(ies) available for hydnocarpin and Precursor-Cell-Lymphoblastic-Leukemia-Lymphoma
| Article | Year |
|---|---|
Inhibitory effect of hydnocarpin D on T-cell acute lymphoblastic leukemia via induction of autophagy-dependent ferroptosis.
Topics: Antineoplastic Agents; Autophagy; Autophagy-Related Proteins; Cell Cycle; Ferroptosis; Flavonolignans; Glutathione; Glutathione Peroxidase; Humans; Jurkat Cells; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reactive Oxygen Species | 2021 |
Potentiating effect of the flavonolignan (-)-hydnocarpin in combination with vincristine in a sensitive and P-gp-expressing acute lymphoblastic leukemia cell line.
The potentiating action of the flavonolignan, (-)-hydnocarpin, in combination with vincristine was evaluated in the 697 acute lymphoblastic leukemia cell line and a P-gp-expressing variant, 697-R. Vincristine at 3 nM caused nearly complete growth inhibition in 697 cells versus a 17% growth inhibition in 697-R cells. When combined with (-)-hydnocarpin at concentrations of 10 and 5 μM, vincristine-mediated growth inhibition in the 697-R cells increased significantly over the sum of the individual agents to 72% (p ≤ 0.0001) and 41% (p = 0.0256), respectively. Vincristine at 1.5 nM (66% growth inhibition) and 0.75 nM (39% growth inhibition) combined with (-)-hydnocarpin at 10 μM (42% growth inhibition) in the 697 cells caused a significant increase in growth inhibition to 83% (p = 0.03) and to 61% (p < 0.0001), respectively, when compared to vincristine treatment as a single agent. To investigate the mechanism for the vincristine re-sensitization caused by (-)-hydnocarpin, the P-gp inhibitory effect of (-)-hydnocarpin was evaluated. Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Drug Resistance, Neoplasm; Flavonolignans; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vincristine | 2013 |