hydnocarpin has been researched along with Colonic-Neoplasms* in 1 studies
1 other study(ies) available for hydnocarpin and Colonic-Neoplasms
| Article | Year |
|---|---|
Anti-proliferative activity of hydnocarpin, a natural lignan, is associated with the suppression of Wnt/β-catenin signaling pathway in colon cancer cells.
Based on the Wnt inhibitors as potential targets in the development of anticancer agents, natural compounds were evaluated for β-catenin-mediated transcriptional activity. A natural lignan hydnocarpin isolated from Lonicera japonica was considered a potential inhibitor for Wnt/β-catenin signalings. The anti-proliferative activity of hydnocarpin was also found to be associated with the suppression of Wnt/β-catenin-mediated signaling pathway in human colon cancer cells. These data suggest that hydnocarpin might be a novel Wnt inhibitor and has a potential of signaling regulator in β-catenin-mediated signaling pathways. Topics: Antineoplastic Agents, Phytogenic; Axin Protein; beta Catenin; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Flavonolignans; Humans; Lignans; Lonicera; RNA Interference; RNA, Small Interfering; Wnt Proteins; Wnt Signaling Pathway | 2013 |