hycanthone has been researched along with Schistosoma mansoni Infection in 13 studies
Hycanthone: Potentially toxic, but effective antischistosomal agent, it is a metabolite of LUCANTHONE.
hycanthone : A thioxanthen-9-one compound having a hydroxymethyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. It was formerly used (particularly as the monomethanesulfonic acid salt) as a schistosomicide for individual or mass treatement of infection with Schistosoma haematobium and S. mansoni, but due to its toxicity and concern about possible carcinogenicity, it has been replaced by other drugs such as praziquantel.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mice with 64-day-old Schistosoma mansoni infection (+/- 27 worms, 8-12 pairs) were treated simultaneously with oxamniquine and hycanthone." | 3.67 | Evolution of the schistosomal hepatic lesions in mice after curative chemotherapy. ( Andrade, ZA; Grimaud, JA, 1986) |
| "Nephrotic syndrome was the most frequent clinical presentation in both groups." | 1.28 | Schistosoma mansoni-induced mesangiocapillary glomerulonephritis: influence of therapy. ( Brito, E; Martinelli, R; Noblat, AC; Rocha, H, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (76.92) | 18.7374 |
| 1990's | 2 (15.38) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pica-Mattoccia, L | 2 |
| Moroni, R | 2 |
| Tchuem Tchuenté, LA | 1 |
| Southgate, VR | 1 |
| Cioli, D | 2 |
| Nabih, I | 1 |
| Rizk, M | 1 |
| Soliman, AM | 1 |
| Martinelli, R | 2 |
| Noblat, AC | 1 |
| Brito, E | 1 |
| Rocha, H | 2 |
| Sabah, AA | 2 |
| Fletcher, C | 2 |
| Webbe, G | 2 |
| Doenhoff, MJ | 2 |
| Andrade, ZA | 1 |
| Grimaud, JA | 1 |
| Pereira, LJ | 1 |
| Do Vale, EC | 1 |
| Furtado, T | 1 |
| Brindley, PJ | 1 |
| Sher, A | 1 |
| Schiltz, JR | 1 |
| Olds, GR | 1 |
| Kresina, TF | 1 |
| Mahmoud, AA | 1 |
| Ouma, JH | 1 |
| Wijers, DJ | 1 |
| Arap Siongok, TK | 1 |
| Berberian, DA | 1 |
| Freele, H | 1 |
| Rosi, D | 1 |
| Dennis, EW | 1 |
| Archer, S | 1 |
13 other studies available for hycanthone and Schistosoma mansoni Infection
| Article | Year |
|---|---|
Changes of mate occur in Schistosoma mansoni.
Topics: Animals; Biomphalaria; Drug Resistance; Female; Hycanthone; Male; Mice; Schistosoma mansoni; Schisto | 2000 |
Studies on carbohydrates extracted from native and chemically treated Biomphalaria alexandrina snails.
Topics: Animals; Biomphalaria; Carbohydrates; Hycanthone; Intestines; Lethal Dose 50; Liver; Lucanthone; Mic | 1992 |
Schistosoma mansoni: hycanthone/oxamniquine resistance is controlled by a single autosomal recessive gene.
Topics: Animals; Crosses, Genetic; Drug Resistance; Female; Fertility; Genes, Helminth; Genes, Recessive; Hy | 1992 |
Schistosoma mansoni-induced mesangiocapillary glomerulonephritis: influence of therapy.
Topics: Adult; Antihypertensive Agents; Cyclophosphamide; Diet, Sodium-Restricted; Diuretics; Female; Follow | 1989 |
Schistosoma mansoni: chemotherapy of infections of different ages.
Topics: Animals; Antimony Potassium Tartrate; Diphenylamine; Female; Hycanthone; Isothiocyanates; Mice; Mice | 1986 |
Evolution of the schistosomal hepatic lesions in mice after curative chemotherapy.
Topics: Animals; Female; Fluorescent Antibody Technique; Hycanthone; Liver; Male; Mice; Microscopy, Electron | 1986 |
The influence of anti-parasitic therapy on the course of the glomerulopathy associated with Schistosomiasis mansoni.
Topics: Humans; Hycanthone; Kidney; Kidney Diseases; Oxamniquine; Schistosomiasis mansoni; Schistosomicides | 1987 |
[Ectopic cutaneous schistosomiasis caused by Schistosoma mansoni].
Topics: Adult; Antiparasitic Agents; Female; Humans; Hycanthone; Schistosomiasis mansoni; Skin Diseases, Par | 1987 |
Anti-schistosomal drugs: observations on the mechanism of drug resistance to hycanthone, and on the involvement of host antibodies in the mode of action of praziquantel.
Topics: Animals; Antibodies, Helminth; Antibody-Dependent Cell Cytotoxicity; Drug Resistance; Hycanthone; Mi | 1987 |
Effect of chemotherapy on hepatic collagen and glycosaminoglycan metabolism in Schistosoma mansoni-infected mice.
Topics: Animals; Collagen; Dose-Response Relationship, Drug; Glycosaminoglycans; Granuloma; Hycanthone; Live | 1988 |
The effect of repeated targeted mass treatment on the prevalence of schistosomiasis mansoni and the intensity of infection in Machakos, Kenya.
Topics: Adolescent; Adult; Child; Child, Preschool; Feces; Female; Humans; Hycanthone; Infant; Kenya; Male; | 1985 |
Schistosoma mansoni: reduced efficacy of chemotherapy in infected T-cell-deprived mice.
Topics: Animals; Antilymphocyte Serum; Diphenylamine; Hycanthone; Isothiocyanates; Mice; Mice, Inbred CBA; O | 1985 |
A comparison of oral and parenteral activity of hycanthone and lucanthone in experimental infections with Schistosoma mansoni.
Topics: Administration, Oral; Animals; Cricetinae; Hycanthone; Injections, Intramuscular; Lucanthone; Mesocr | 1967 |