hycanthone has been researched along with Liver Neoplasms in 4 studies
Hycanthone: Potentially toxic, but effective antischistosomal agent, it is a metabolite of LUCANTHONE.
hycanthone : A thioxanthen-9-one compound having a hydroxymethyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. It was formerly used (particularly as the monomethanesulfonic acid salt) as a schistosomicide for individual or mass treatement of infection with Schistosoma haematobium and S. mansoni, but due to its toxicity and concern about possible carcinogenicity, it has been replaced by other drugs such as praziquantel.
Liver Neoplasms: Tumors or cancer of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In confirmation of an earlier study, it was found that in mice infected with Schistosoma mansoni hepatocellular carcinomas are induced by hycanthone, an antischistosomal drug and potent frameshift mutagen." | 3.65 | Long-term hepatocellular effects of hycanthone and of two other anti-Schistosomal drugs in mice infected with Schistosoma mansoni. ( Bueding, E; Haese, WH, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Haese, WH | 1 |
| Bueding, E | 2 |
| Liau, MC | 1 |
| Lin, GW | 1 |
| Knight, CA | 1 |
| Hurlbert, RB | 1 |
| Tsuda, H | 1 |
| Sarma, DS | 1 |
| Rajalakshmi, S | 1 |
| Zubroff, J | 1 |
| Farber, E | 1 |
| Batzinger, RP | 1 |
| Cha, YN | 1 |
| Hartman, PE | 1 |
4 other studies available for hycanthone and Liver Neoplasms
| Article | Year |
|---|---|
Long-term hepatocellular effects of hycanthone and of two other anti-Schistosomal drugs in mice infected with Schistosoma mansoni.
Topics: Animals; Carcinoma, Hepatocellular; Female; Hycanthone; Indazoles; Liver; Liver Neoplasms; Mice; Nit | 1976 |
Inhibition of RNA methylation by intercalating agents.
Topics: Alkaloids; Animals; Carcinoma, Hepatocellular; Cell Nucleolus; Ellipticines; Ethidium; Hycanthone; I | 1977 |
Induction of hepatic neoplastic lesions in mice with a single dose of hycanthone methanesulfonate after partial hepatectomy.
Topics: Animals; Hepatectomy; Hycanthone; Liver Neoplasms; Liver Neoplasms, Experimental; Liver Regeneration | 1979 |
Early years of the Salmonella mutagen tester strains: lessons from hycanthone.
Topics: Animals; History, 20th Century; Humans; Hycanthone; Liver Neoplasms; Mutagenicity Tests; Mutagens; M | 1989 |