hycanthone has been researched along with Experimental Neoplasms in 4 studies
Hycanthone: Potentially toxic, but effective antischistosomal agent, it is a metabolite of LUCANTHONE.
hycanthone : A thioxanthen-9-one compound having a hydroxymethyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. It was formerly used (particularly as the monomethanesulfonic acid salt) as a schistosomicide for individual or mass treatement of infection with Schistosoma haematobium and S. mansoni, but due to its toxicity and concern about possible carcinogenicity, it has been replaced by other drugs such as praziquantel.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hycanthone was administered to Schistosoma mansoni-infected and non-infected Syrian golden hamsters and Swiss mice by intraperitoneal and intramuscular injection of amounts up to the maximum tolerated dose." | 1.26 | Carcinogenic potential of hycanthone in mice and hamsters. ( Bulay, O; Clayson, DB; Patil, K; Shubik, P; Urman, H, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liau, MC | 1 |
| Lin, GW | 1 |
| Knight, CA | 1 |
| Hurlbert, RB | 1 |
| Davies, BM | 1 |
| Watling, DC | 1 |
| Bulay, O | 1 |
| Urman, H | 1 |
| Patil, K | 1 |
| Clayson, DB | 1 |
| Shubik, P | 1 |
4 other studies available for hycanthone and Experimental Neoplasms
| Article | Year |
|---|---|
IARC monographs on the evaluation of the carcinogenic risk of chemicals to man: some miscellaneous pharmaceutical substances.
Topics: Acriflavine; Animals; Anthralin; Aurothioglucose; Carcinogens; Chloroquine; Diazepam; Ethanolamines; | 1977 |
Inhibition of RNA methylation by intercalating agents.
Topics: Alkaloids; Animals; Carcinoma, Hepatocellular; Cell Nucleolus; Ellipticines; Ethidium; Hycanthone; I | 1977 |
Radiosensitization of pulmonary metastases-I. In vivo testing of hycanthone, insulin and razoxane.
Topics: Animals; Hycanthone; Insulin; Lung Neoplasms; Mice; Neoplasm Transplantation; Neoplasms, Experimenta | 1979 |
Carcinogenic potential of hycanthone in mice and hamsters.
Topics: Animals; Carcinogens; Chemical Phenomena; Chemistry; Cricetinae; Female; Hycanthone; Hyperplasia; In | 1979 |