hycanthone has been researched along with Experimental Leukemia in 3 studies
Hycanthone: Potentially toxic, but effective antischistosomal agent, it is a metabolite of LUCANTHONE.
hycanthone : A thioxanthen-9-one compound having a hydroxymethyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. It was formerly used (particularly as the monomethanesulfonic acid salt) as a schistosomicide for individual or mass treatement of infection with Schistosoma haematobium and S. mansoni, but due to its toxicity and concern about possible carcinogenicity, it has been replaced by other drugs such as praziquantel.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chromosome abnormalities were present in cells from 12% (7/60) of the UC colonies, but there was no apparent relationship between colony diameter and the presence of chromosomal abnormalities." | 1.28 | Chromosome analysis of small and large L5178Y mouse lymphoma cell colonies: comparison of trifluorothymidine-resistant and unselected cell colonies from mutagen-treated and control cultures. ( Blazak, WF; Caspary, WJ; Los, FJ; Rudd, CJ, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Archer, S | 1 |
| Pica-Mattoccia, L | 1 |
| Cioli, D | 1 |
| Seyed-Mozaffari, A | 1 |
| Zayed, AH | 1 |
| Blazak, WF | 2 |
| Los, FJ | 1 |
| Rudd, CJ | 2 |
| Caspary, WJ | 2 |
| Stewart, BE | 1 |
| Galperin, I | 1 |
| Allen, KL | 1 |
| Mitchell, AD | 1 |
3 other studies available for hycanthone and Experimental Leukemia
| Article | Year |
|---|---|
Preparation and antischistosomal and antitumor activity of hycanthone and some of its congeners. Evidence for the mode of action of hycanthone.
Topics: Animals; Antineoplastic Agents; Hycanthone; Indicators and Reagents; Leukemia P388; Leukemia, Experi | 1988 |
Chromosome analysis of small and large L5178Y mouse lymphoma cell colonies: comparison of trifluorothymidine-resistant and unselected cell colonies from mutagen-treated and control cultures.
Topics: Animals; Chromosome Aberrations; Dimethyl Sulfoxide; Hycanthone; Leukemia L5178; Leukemia, Experimen | 1989 |
Stable dicentric chromosomes induced by chemical mutagens in L5178Y mouse lymphoma cells.
Topics: Acrolein; Anaphase; Animals; Cells, Cultured; Chromosome Aberrations; Hycanthone; Karyotyping; Leuke | 1986 |