hycanthone has been researched along with Chemical and Drug Induced Liver Injury in 20 studies
Hycanthone: Potentially toxic, but effective antischistosomal agent, it is a metabolite of LUCANTHONE.
hycanthone : A thioxanthen-9-one compound having a hydroxymethyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. It was formerly used (particularly as the monomethanesulfonic acid salt) as a schistosomicide for individual or mass treatement of infection with Schistosoma haematobium and S. mansoni, but due to its toxicity and concern about possible carcinogenicity, it has been replaced by other drugs such as praziquantel.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "5 mg of hycanthone per kg of body weight for schistosomiasis, showed features of a toxic hepatitis with massive hepatic necrosis, many acidophil bodies and minimal inflammatory response in 2 patients, and confluent necrosis with early fibrosis in 1." | 3.66 | Liver pathology in hycanthone hepatitis. ( Cohen, C, 1978) |
| "Hycanthone was given to 15 patients with metastatic cancer in order to determine the maximum tolerable dose." | 2.64 | Phase I study of hycanthone. ( Bodey, GP; Grose, WE; Legha, SS, 1978) |
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (75.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Ekins, S | 1 |
| Williams, AJ | 1 |
| Xu, JJ | 1 |
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 1 |
| Sakatis, MZ | 1 |
| Reese, MJ | 1 |
| Harrell, AW | 1 |
| Taylor, MA | 1 |
| Baines, IA | 1 |
| Chen, L | 1 |
| Bloomer, JC | 1 |
| Yang, EY | 1 |
| Ellens, HM | 1 |
| Ambroso, JL | 1 |
| Lovatt, CA | 1 |
| Ayrton, AD | 1 |
| Clarke, SE | 1 |
| Warner, DJ | 1 |
| Chen, H | 1 |
| Cantin, LD | 1 |
| Kenna, JG | 1 |
| Stahl, S | 1 |
| Walker, CL | 1 |
| Noeske, T | 1 |
| Mengistu, M | 1 |
| Gonçalves, CS | 1 |
| Buaiz, V | 1 |
| Zanandréa, J | 1 |
| Zanotti, WM | 1 |
| Boni, ES | 1 |
| de Castro Filho, AK | 1 |
| Pereira, FE | 1 |
| Legha, SS | 1 |
| Grose, WE | 1 |
| Bodey, GP | 1 |
| Cohen, C | 1 |
| Gigase, PL | 1 |
| Mortelmans, J | 1 |
| Van Marck, EA | 1 |
| Buchanan, N | 2 |
| Thatcher, CJ | 1 |
| Cane, RD | 1 |
| Bartolomeo, B | 1 |
| Dennis, EW | 2 |
| Hatchuel, W | 1 |
| Kallmeyer, JC | 1 |
| MacSearraigh, ET | 1 |
| Godlonton, JD | 1 |
| Ward, JM | 1 |
| Stolte, JB | 1 |
| Cook, JA | 1 |
| Jordan, P | 1 |
| Genève, J | 1 |
| Larrey, D | 1 |
| Pessayre, D | 1 |
| Benhamou, JP | 1 |
| Kobus, W | 1 |
1 review available for hycanthone and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
A review of the clinical pharmacology of hycanthone.
Topics: Administration, Oral; Adolescent; Adult; Africa; Animals; Blood Pressure; Body Temperature; Body Wei | 1974 |
1 trial available for hycanthone and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Phase I study of hycanthone.
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Drug Administration S | 1978 |
18 other studies available for hycanthone and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
Fatal liver toxicity due to hycanthone (Etrenol) in a patient with pre-existing liver disease: a case report.
Topics: Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Hycanthone; Liver Diseases, Parasitic | 1982 |
[Toxic reactions with the use of hycanthone].
Topics: Adult; Chemical and Drug Induced Liver Injury; Drug Evaluation; Female; Humans; Hycanthone; Liver; M | 1977 |
Liver pathology in hycanthone hepatitis.
Topics: Chemical and Drug Induced Liver Injury; Child; Female; Humans; Hycanthone; Liver; Male; Schistosomia | 1978 |
[Fatal hepatic necrosis after administration of hycanthone].
Topics: Adult; Chemical and Drug Induced Liver Injury; Humans; Hycanthone; Liver; Male; Necrosis; Schistosom | 1979 |
Hycanthone--a danger associated with its use.
Topics: Chemical and Drug Induced Liver Injury; Child; Humans; Hycanthone; Necrosis; Thioxanthenes | 1977 |
Fatal hepatic necrosis in association with the use of hycanthone. A case report.
Topics: Acute Disease; Chemical and Drug Induced Liver Injury; Child; Humans; Hycanthone; Necrosis; Thioxant | 1978 |
Fatal hepatic necrosis in association with the use of hycanthone.
Topics: Chemical and Drug Induced Liver Injury; Hycanthone; Mortality; Necrosis; Schistosomiasis; Thioxanthe | 1978 |
Fatal hepatic necrosis in association with hycanthone.
Topics: Chemical and Drug Induced Liver Injury; Humans; Hycanthone; Necrosis; Nitroquinolines; Oxamniquine; | 1978 |
Hepatic and renal failure after misuse of hycanthone.
Topics: Acute Kidney Injury; Adult; Chemical and Drug Induced Liver Injury; Child; Female; Humans; Hycanthon | 1977 |
Case report: Severe jaundice following hycanthone.
Topics: Adolescent; Chemical and Drug Induced Liver Injury; Humans; Hycanthone; Liver; Male; Thioxanthenes | 1975 |
[Letter: 3 deaths following administration of hycanthone (Etrenol)].
Topics: Chemical and Drug Induced Liver Injury; Child; Female; Humans; Hycanthone; Male; Schistosomiasis; So | 1976 |
Absence of liver toxicity in 2723 patients treated with hycanthone in St. Lucia.
Topics: Chemical and Drug Induced Liver Injury; Humans; Hycanthone; Schistosomiasis; Thioxanthenes; West Ind | 1976 |
[Tricyclic structure of drugs and hepatotoxicity].
Topics: Anticonvulsants; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Appetite; Chemical and Drug | 1987 |