hycanthone has been researched along with Bilharziasis in 75 studies
Hycanthone: Potentially toxic, but effective antischistosomal agent, it is a metabolite of LUCANTHONE.
hycanthone : A thioxanthen-9-one compound having a hydroxymethyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. It was formerly used (particularly as the monomethanesulfonic acid salt) as a schistosomicide for individual or mass treatement of infection with Schistosoma haematobium and S. mansoni, but due to its toxicity and concern about possible carcinogenicity, it has been replaced by other drugs such as praziquantel.
| Excerpt | Relevance | Reference |
|---|---|---|
| "One hundred patients with active schistosomiasis mansoni were treated with niridazole (25 mg/kg/day po for 7 days)." | 9.04 | Clinical evaluation of niridazole and hycanthone in schistosomiasis mansoni endemic areas. ( Katz, N, 1975) |
| "Fourteen patients with active schistosomiasis mansoni in spite of previous treatment with oxamniquine and/or hycanthone were treated with praziquantel, single oral dose of 45 to 50 mg/kg body-weight." | 7.66 | Use of praziquantel in patients with schistosomiasis mansoni previously treated with oxamniquine and/or hycanthone: resistance of Schistosoma mansoni to schistosomicidal agents. ( de Jesus Pedro, R; de Souza Dias, LC; Deberaldini, ER, 1982) |
| "Clinical trials of hycanthone (single intramuscular dose) were undertaken in schistosomiasis mansoni patients in St." | 7.65 | Hycanthone dose-response in treatment of schistosomiasis mansoni in St. Lucia. ( Armitage, P; Cook, JA; Jordan, P, 1976) |
| "One hundred patients with active schistosomiasis mansoni were treated with niridazole (25 mg/kg/day po for 7 days)." | 5.04 | Clinical evaluation of niridazole and hycanthone in schistosomiasis mansoni endemic areas. ( Katz, N, 1975) |
| "Hycanthone (HYC) is a retired drug formerly used to treat schistosomiasis caused by infection from Schistosoma mansoni and S." | 3.96 | Molecular basis for hycanthone drug action in schistosome parasites. ( Cao, X; Guzman, M; LoVerde, PT; McHardy, SF; Rugel, A; Tarpley, RS; Taylor, AB, 2020) |
| "Fourteen patients with active schistosomiasis mansoni in spite of previous treatment with oxamniquine and/or hycanthone were treated with praziquantel, single oral dose of 45 to 50 mg/kg body-weight." | 3.66 | Use of praziquantel in patients with schistosomiasis mansoni previously treated with oxamniquine and/or hycanthone: resistance of Schistosoma mansoni to schistosomicidal agents. ( de Jesus Pedro, R; de Souza Dias, LC; Deberaldini, ER, 1982) |
| "Acting as their own controls, village subjects from the Gezira are of the Sudan with relatively high levels of schistosomiasis infection were first tested in an exercise laboratory in Khartoum and the tests were then repeated after a period of about 1 yr during which time the subjects were treated with hycanthone and periodically monitored to ensure that they had remained free of the disease." | 3.66 | An assessment of anti-schistosomal treatment on physical work capacity. ( Amin, MA; Awad El Karim, MA; Collins, KJ; Doré, C; Omer, AH; Sukkar, MY, 1981) |
| "5 mg of hycanthone per kg of body weight for schistosomiasis, showed features of a toxic hepatitis with massive hepatic necrosis, many acidophil bodies and minimal inflammatory response in 2 patients, and confluent necrosis with early fibrosis in 1." | 3.66 | Liver pathology in hycanthone hepatitis. ( Cohen, C, 1978) |
| "In confirmation of an earlier study, it was found that in mice infected with Schistosoma mansoni hepatocellular carcinomas are induced by hycanthone, an antischistosomal drug and potent frameshift mutagen." | 3.65 | Long-term hepatocellular effects of hycanthone and of two other anti-Schistosomal drugs in mice infected with Schistosoma mansoni. ( Bueding, E; Haese, WH, 1976) |
| "Clinical trials of hycanthone (single intramuscular dose) were undertaken in schistosomiasis mansoni patients in St." | 3.65 | Hycanthone dose-response in treatment of schistosomiasis mansoni in St. Lucia. ( Armitage, P; Cook, JA; Jordan, P, 1976) |
| " A very low dosage of hycanthone (0." | 2.65 | Failure of targeted mass treatment to control schistosomiasis. ( Manshande, JP; Polderman, AM, 1981) |
| "Praziquantel was the most effective drug; a dose of 100 mg/kg given orally for 5 days resulted in a 95% reduction in worm burdens." | 1.28 | Experimental chemotherapy of Schistosoma curassoni in mice. ( Hilderson, H; Rollinson, D; Southgate, VR; Vercruysse, J, 1989) |
| "The effects of Astiban, Lucanthone, Hycanthone and Niridazole on autophagic activities in the gastrodermis of Schistosoma mansoni were determined in vivo, using different dosage levels and dosage times." | 1.27 | Schistosoma mansoni: an in vivo study of drug-induced autophagy in the gastrodermis. ( Clarkson, J; Erasmus, DA, 1984) |
| " A dose-response to the antischistosomal drug, hycanthone was established for three different doses in 169 patients with heavy S." | 1.26 | Hycanthone dose-response in Schistosoma mansoni infection in Kenya. ( Houser, HB; Ouma, JH; Siongok, TK; Warren, KS, 1978) |
| "Hycanthone was given as a single intramuscular injection at a dose of 3." | 1.26 | Hycanthone therapy in selected patients with S. mansoni and S. haematobium infections in the Sudan. ( Abu Sabaa, H; Mustafa, D; Salih, SY, 1978) |
| "Hycanthone was administered to Schistosoma mansoni-infected and non-infected Syrian golden hamsters and Swiss mice by intraperitoneal and intramuscular injection of amounts up to the maximum tolerated dose." | 1.26 | Carcinogenic potential of hycanthone in mice and hamsters. ( Bulay, O; Clayson, DB; Patil, K; Shubik, P; Urman, H, 1979) |
| "Hycanthone has a schistosomicidal effect against S." | 1.26 | Hycanthone in the treatment of Egyptian bilharzial patients. ( Gawish, N, 1976) |
| "The frequency of cells presenting chromosome abnormalities was determined in patients with schistosomiasis before and after treatment with a single dose of 2." | 1.25 | A study of chromosomes of lymphocytes from patients treated with hycanthone. ( Chamone, DA; Da Silva, LC; Ferreira, NR; Frota-Pessoa, O; Moro, AM; Otto, PA; Pedroso, MB, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 73 (97.33) | 18.7374 |
| 1990's | 1 (1.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (1.33) | 2.80 |
| Authors | Studies |
|---|---|
| Guzman, M | 1 |
| Rugel, A | 1 |
| Tarpley, RS | 1 |
| Cao, X | 1 |
| McHardy, SF | 1 |
| LoVerde, PT | 1 |
| Taylor, AB | 1 |
| Polderman, AM | 1 |
| Manshande, JP | 1 |
| Clarkson, J | 1 |
| Erasmus, DA | 1 |
| Everson, RB | 1 |
| Gad-El-Mawla, NM | 1 |
| Attia, MA | 1 |
| Chevlen, EM | 1 |
| Thorgeirsson, SS | 1 |
| Alexander, LA | 1 |
| Flack, PM | 1 |
| Staiano, N | 1 |
| Ziegler, JL | 1 |
| De Cock, KM | 1 |
| Sturrock, RF | 1 |
| Kimani, R | 1 |
| Cottrell, BJ | 1 |
| Butterworth, AE | 1 |
| Seitz, HM | 1 |
| Siongok, TK | 2 |
| Houba, V | 1 |
| de Almeida, MA | 1 |
| Andrade, ZA | 2 |
| Cioli, D | 2 |
| Pica Mattoccia, L | 1 |
| Soliman, R | 1 |
| Mokhtar, HM | 1 |
| el Sadany, SK | 1 |
| Iarotski, LS | 1 |
| Davis, A | 2 |
| Azevedo de Brito, P | 1 |
| Mengistu, M | 1 |
| de Souza Dias, LC | 1 |
| de Jesus Pedro, R | 1 |
| Deberaldini, ER | 1 |
| Gilles, HM | 1 |
| Awad El Karim, MA | 1 |
| Collins, KJ | 1 |
| Sukkar, MY | 1 |
| Omer, AH | 1 |
| Amin, MA | 1 |
| Doré, C | 1 |
| McMahon, JE | 1 |
| Knopf, PM | 1 |
| Doenhoff, M | 1 |
| Bickle, Q | 1 |
| Bain, J | 1 |
| Webbe, G | 1 |
| Nelson, G | 1 |
| Araujo, N | 1 |
| Katz, N | 3 |
| Pinto Dias, E | 1 |
| de Souza, CP | 1 |
| Jordan, P | 7 |
| Cook, JA | 6 |
| Bartholomew, RK | 2 |
| Grist, E | 1 |
| Auguste, E | 1 |
| Brindley, PJ | 1 |
| Coulaud, JP | 1 |
| Payet, M | 1 |
| Yokogawa, M | 1 |
| Warren, KS | 2 |
| Ouma, JH | 1 |
| Houser, HB | 1 |
| Haese, WH | 1 |
| Bueding, E | 1 |
| Mousa, AH | 3 |
| Gonçalves, CS | 2 |
| Buaiz, V | 2 |
| Zanandréa, J | 1 |
| Zanotti, WM | 2 |
| Boni, ES | 2 |
| de Castro Filho, AK | 1 |
| Pereira, FE | 2 |
| Guimarães, RX | 2 |
| Tchakerian, A | 1 |
| Dias, LC | 2 |
| de Almeida, FM | 1 |
| Vilela, MP | 1 |
| Cabeca, M | 1 |
| Takeda, AK | 1 |
| Woodstock, L | 1 |
| Pilgrim, V | 1 |
| Fleischer, NK | 1 |
| Cohen, C | 1 |
| Reid, WA | 1 |
| Loizeaux, PS | 1 |
| Reardon, MJ | 1 |
| Pedro, RD | 1 |
| Amato Neto, V | 1 |
| De Carvalho, SA | 1 |
| Gigase, PL | 1 |
| Mortelmans, J | 1 |
| Van Marck, EA | 1 |
| El-Kabbaj, M | 1 |
| Hassar, M | 1 |
| Hanna, SK | 1 |
| Khayyal, MT | 1 |
| Saleh, S | 1 |
| Farid, F | 1 |
| Abdulla, WA | 1 |
| Saad, AA | 2 |
| El-Zoghby, SM | 2 |
| Farag, HF | 3 |
| el-Sewedy, SM | 2 |
| Girgis, LH | 2 |
| Moghazy, M | 2 |
| Magzoub, M | 1 |
| Adam, SE | 1 |
| Dennis, EW | 3 |
| Salih, SY | 3 |
| Abu Sabaa, H | 1 |
| Mustafa, D | 1 |
| Voller, A | 2 |
| Woodruff, AW | 1 |
| Hatchuel, W | 1 |
| Bartlett, A | 1 |
| Baquir, H | 1 |
| Bulay, O | 1 |
| Urman, H | 1 |
| Patil, K | 1 |
| Clayson, DB | 1 |
| Shubik, P | 1 |
| Sotomayor, ZR | 1 |
| Febles, F | 1 |
| Ramos Morales, F | 1 |
| Sanchez, G | 1 |
| Rivera, M | 1 |
| Pereira, LH | 1 |
| Pellegrino, J | 1 |
| Mello, RT | 1 |
| Hillman, GR | 1 |
| Gibler, WB | 1 |
| Anderson, JB | 1 |
| Armitage, P | 1 |
| Gawish, N | 1 |
| Guirguis, RS | 1 |
| Sherif, A | 1 |
| Hanna, AT | 1 |
| Mahmoud, AA | 1 |
| Soares, D | 1 |
| Domingues, SH | 1 |
| de Pádua Vilela, M | 1 |
| Tonelli, E | 1 |
| Penna, FJ | 1 |
| Leão, E | 1 |
| Miranda, D | 1 |
| Rees, PH | 2 |
| Bowry, HN | 1 |
| Roberts, JM | 2 |
| Thuku, JJ | 1 |
| Frota-Pessoa, O | 1 |
| Ferreira, NR | 1 |
| Pedroso, MB | 1 |
| Moro, AM | 1 |
| Otto, PA | 1 |
| Chamone, DA | 1 |
| Da Silva, LC | 1 |
| Stolte, JB | 1 |
| Vercruysse, J | 1 |
| Southgate, VR | 1 |
| Rollinson, D | 1 |
| Hilderson, H | 1 |
| Archer, S | 1 |
| Farah, A | 1 |
| Berberian, DA | 1 |
| Davison, C | 1 |
| Donikian, MA | 1 |
| Drobeck, HP | 1 |
| Ferrari, RA | 1 |
| Yarinsky, A | 1 |
| Ongom, VL | 1 |
| El-Abdin, AZ | 2 |
| El-Garem, AA | 1 |
| El-Raziky, EH | 2 |
| Fadl, AA | 1 |
| Rbook, J | 1 |
| Munguti, J | 1 |
| Samy, G | 1 |
| Roshdy, MZ | 1 |
| Abd-El-Rahman, H | 1 |
| Hafez, S | 1 |
| Adham, IA | 1 |
| Kobus, W | 1 |
| Abdallah, A | 1 |
| Saif, M | 1 |
| Abdel-Fattah, F | 1 |
| Abdel-Meguid, M | 1 |
| Badran, A | 1 |
6 reviews available for hycanthone and Bilharziasis
| Article | Year |
|---|---|
Human schistosomiasis and its management.
Topics: Animals; Humans; Hycanthone; Oxamniquine; Praziquantel; Schistosoma; Schistosomiasis; Trichlorfon | 1984 |
Drug resistance to schistosomicides and other anthelmintics of medical significance.
Topics: Animals; Anthelmintics; Base Sequence; DNA Primers; Drug Resistance; Gene Rearrangement; Helminthias | 1994 |
Chemotherapy of Schistosomiasis mansoni.
Topics: Amphotericin B; Animals; Antimony; Chemosterilants; Drug Evaluation; Drug Evaluation, Preclinical; E | 1977 |
[Central nervous system involvement in parasitic tropical diseases].
Topics: Adult; Blood-Brain Barrier; Central Nervous System Diseases; Cysticercosis; Female; Hartmannella; Hu | 1979 |
The chemotherapy of schistosomiasis.
Topics: Animals; Chemical Phenomena; Chemistry; Diphenylamine; Humans; Hycanthone; Isothiocyanates; Niridazo | 1985 |
A review of the clinical pharmacology of hycanthone.
Topics: Administration, Oral; Adolescent; Adult; Africa; Animals; Blood Pressure; Body Temperature; Body Wei | 1974 |
6 trials available for hycanthone and Bilharziasis
| Article | Year |
|---|---|
Failure of targeted mass treatment to control schistosomiasis.
Topics: Communicable Disease Control; Democratic Republic of the Congo; Feces; Humans; Hycanthone; Parasite | 1981 |
A controlled trial of hycanthone and placebo in schistosomiasis mansoni in St. Lucia.
Topics: Adolescent; Animals; Child; Clinical Trials as Topic; Enzymes; Female; Humans; Hycanthone; Male; Par | 1977 |
Clinical treatment of schistosomiasis mansoni with a new schistosomicidal agent: hycanthone or etrenol.
Topics: Clinical Trials as Topic; Female; Humans; Hycanthone; Male; Placebos; Schistosoma mansoni; Schistoso | 1976 |
Clinical evaluation of niridazole and hycanthone in schistosomiasis mansoni endemic areas.
Topics: Adult; Age Factors; Brazil; Child; Clinical Trials as Topic; Drug Evaluation; Feces; Female; Humans; | 1975 |
The treatment of schistosomiasis mansoni in Murang'a District, Kenya: a double blind controlled trial of three hycanthone regimens and oxamniquine.
Topics: Adolescent; Body Weight; Child; Dose-Response Relationship, Drug; Drug Evaluation; Female; Humans; H | 1975 |
The effect of a second dose of hycanthone alone and with progesterone caproate on the cure rate and the side reactions of hycanthone in the treatment of S. haematobium infected cases.
Topics: Adolescent; Blood Cell Count; Blood Proteins; Caproates; Child; Clinical Trials as Topic; Drug Syner | 1974 |
63 other studies available for hycanthone and Bilharziasis
| Article | Year |
|---|---|
Molecular basis for hycanthone drug action in schistosome parasites.
Topics: Animals; Crystallization; Crystallography, X-Ray; Drug Design; Drug Resistance; Humans; Hycanthone; | 2020 |
Schistosoma mansoni: an in vivo study of drug-induced autophagy in the gastrodermis.
Topics: Animals; Antimony; Hycanthone; Lucanthone; Mice; Niridazole; Organometallic Compounds; Schistosoma m | 1984 |
Analysis of human urine for mutagens associated with carcinoma of the bilharzial bladder by the Ames Salmonella plate assay.
Topics: Humans; Hycanthone; Mutagenicity Tests; Mutagens; Nitrosamines; Salmonella typhimurium; Schistosoma | 1983 |
Observations on possible immunity to reinfection among Kenyan schoolchildren after treatment for Schistosoma mansoni.
Topics: Adolescent; Age Factors; Antibodies; Child; Eosinophils; Female; Humans; Hycanthone; Kenya; Leukocyt | 1983 |
Effect of chemotherapy on experimental pulmonary schistosomiasis.
Topics: Animals; Granuloma; Hycanthone; Liver; Lung; Lung Diseases, Parasitic; Male; Mice; Nitroquinolines; | 1983 |
Genetic analysis of hycanthone resistance in Schistosoma mansoni.
Topics: Animals; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Feces; Female; Humans; Hycant | 1984 |
Synthesis of new 8-(5-substituted amino-1,3,4-oxadiazol-2-yl) and 8-(5-substituted amino-1,3,4-thiadiazol-2-yl) methoxyquinolines with antibilharzial activity.
Topics: Animals; Hycanthone; Hydroxyquinolines; Intestine, Small; Liver; Mice; Oxadiazoles; Schistosoma mans | 1984 |
The schistosomiasis problem in the world: results of a WHO questionnaire survey.
Topics: Humans; Hycanthone; Molluscacides; Niridazole; Schistosomiasis; Snails; Surveys and Questionnaires | 1981 |
Curative chemotherapy and resistance to reinfection in murine schistosomiasis.
Topics: Animals; Eosinophils; Female; Granuloma; Hycanthone; Inflammation; Liver; Macrophages; Male; Mice; N | 1982 |
Fatal liver toxicity due to hycanthone (Etrenol) in a patient with pre-existing liver disease: a case report.
Topics: Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Hycanthone; Liver Diseases, Parasitic | 1982 |
Use of praziquantel in patients with schistosomiasis mansoni previously treated with oxamniquine and/or hycanthone: resistance of Schistosoma mansoni to schistosomicidal agents.
Topics: Adolescent; Adult; Animals; Child; Drug Resistance; Female; Humans; Hycanthone; Isoquinolines; Mice; | 1982 |
The treatment of schistosomiasis.
Topics: Humans; Hycanthone; Niridazole; Oxamniquine; Praziquantel; Schistosomiasis; Trichlorfon | 1981 |
An assessment of anti-schistosomal treatment on physical work capacity.
Topics: Adolescent; Adult; Disability Evaluation; Exercise Test; Hemoglobinometry; Humans; Hycanthone; Lung | 1981 |
A note on drug trials in schistosomiasis.
Topics: Drug Evaluation; Humans; Hycanthone; Isoquinolines; Praziquantel; Schistosoma haematobium; Schistoso | 1981 |
A study of the mode of action of hycanthone against Schistosoma mansoni in vivo and in vitro.
Topics: Animals; Biotransformation; Cricetinae; Dose-Response Relationship, Drug; Drug Resistance; Hycanthon | 1980 |
Factors affecting the acquisition of resistance against Schistosoma mansoni in the mouse. V. Reduction in the degree of resistance to reinfection after chemotherapeutic elimination of recently patent primary infections.
Topics: Animals; Antimony Potassium Tartrate; Hycanthone; Immunity, Active; Mice; Mice, Inbred CBA; Niridazo | 1980 |
Susceptibility to chemotherapeutic agents of strains of Schistosoma mansoni isolated from treated and untreated patients.
Topics: Adolescent; Adult; Animals; Child; Female; Humans; Hycanthone; Male; Mice; Niridazole; Oxamniquine; | 1980 |
Schistosoma mansoni control in Cul de Sac Valley, Saint Lucia. II. Chemotherapy as a supplement to a focal mollusciciding programme.
Topics: Feces; Humans; Hycanthone; Molluscacides; Oxamniquine; Pest Control; Schistosoma mansoni; Schistosom | 1980 |
[Specific treatment of urinary bilharziasis].
Topics: Drug Tolerance; Emetine; Humans; Hycanthone; Niridazole; Schistosomiasis; Schistosomicides; Trichlor | 1977 |
Current chemotherapy of schistosomiasis in Japan.
Topics: 5-Amino-3-((5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole; Adult; Animals; Antimony; Child; Cricetinae; Hu | 1976 |
Hycanthone dose-response in Schistosoma mansoni infection in Kenya.
Topics: Adolescent; Adult; Child; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Hycan | 1978 |
Long-term hepatocellular effects of hycanthone and of two other anti-Schistosomal drugs in mice infected with Schistosoma mansoni.
Topics: Animals; Carcinoma, Hepatocellular; Female; Hycanthone; Indazoles; Liver; Liver Neoplasms; Mice; Nit | 1976 |
Mass chemotherapy campaigns for control of schistosomiasis in Egypt.
Topics: Benzenesulfonates; Egypt; Hycanthone; Lucanthone; Mass Screening; Niridazole; Rural Health; Schistos | 1976 |
[Toxic reactions with the use of hycanthone].
Topics: Adult; Chemical and Drug Induced Liver Injury; Drug Evaluation; Female; Humans; Hycanthone; Liver; M | 1977 |
[Resistance to hycanthone and oxamniquine in patients with a clinical hepato-intestinal form of schistosomiasis].
Topics: Adult; Animals; Drug Resistance; Female; Humans; Hycanthone; Intestinal Diseases, Parasitic; Liver D | 1979 |
Liver pathology in hycanthone hepatitis.
Topics: Chemical and Drug Induced Liver Injury; Child; Female; Humans; Hycanthone; Liver; Male; Schistosomia | 1978 |
The activity of a benzothiopyranoindazole (IA-4 N-oxide) against Schistosoma mansoni infection in rhesus monkeys.
Topics: Animals; Colon; Granuloma; Haplorhini; Hycanthone; Indazoles; Liver; Macaca mulatta; Parasite Egg Co | 1977 |
Observations on the treatment of mansoni schistosomiasis with oxamniquine.
Topics: Adolescent; Child; Child, Preschool; Feces; Female; Humans; Hycanthone; Liver; Male; Microscopy, Ele | 1979 |
[Fatal hepatic necrosis after administration of hycanthone].
Topics: Adult; Chemical and Drug Induced Liver Injury; Humans; Hycanthone; Liver; Male; Necrosis; Schistosom | 1979 |
[Medical treatment of urogenital bilharziasis].
Topics: Antimony; Humans; Hycanthone; Niridazole; Schistosomiasis; Schistosomicides; Trichlorfon | 1979 |
Effect of hycanthone and niridazole on cholinesterase levels in experimental schistosomiasis.
Topics: Animals; Blood Proteins; Cholinesterases; Female; Hycanthone; Male; Mice; Niridazole; Schistosomiasi | 1978 |
Schistosomiasis--research to control.
Topics: Adolescent; Adult; Animals; Child; Child, Preschool; Costs and Cost Analysis; Disease Vectors; Human | 1977 |
Biochemical studies on beta-glucuronidase in the urinary bladder of normal and Schistosoma mansoni infected mice treated with hycanthone.
Topics: Animals; Glucuronidase; Hycanthone; Mice; Schistosoma mansoni; Schistosomiasis; Thioxanthenes; Urina | 1977 |
Biochemical studies on beta-glucuronidase enzyme in liver and spleen homogenates of normal and Schistosoma mansoni infected mice treated with hycanthone.
Topics: Animals; Glucuronidase; Hycanthone; Liver; Mice; Schistosoma mansoni; Schistosomiasis; Spleen; Stimu | 1978 |
Evaluation of oral therapy of mansonial schistosomiasis in the Sudan using single and multiple doses of hycanthone and oxamniquine drugs.
Topics: Animals; Drug Administration Schedule; Drug Therapy, Combination; Female; Hycanthone; Liver; Male; N | 1978 |
Fatal hepatic necrosis in association with the use of hycanthone.
Topics: Chemical and Drug Induced Liver Injury; Hycanthone; Mortality; Necrosis; Schistosomiasis; Thioxanthe | 1978 |
Hycanthone therapy in selected patients with S. mansoni and S. haematobium infections in the Sudan.
Topics: Adolescent; Adult; Aged; Child; Female; Humans; Hycanthone; Male; Middle Aged; Schistosoma haematobi | 1978 |
Serum immunoglobulin concentrations in human S. mansoni and S. haematobium infections in the Sudan, with special reference to the effect of chemotherapy.
Topics: Adolescent; Adult; Feces; Female; Humans; Hycanthone; Immunoglobulin A; Immunoglobulin G; Immunoglob | 1978 |
Fatal hepatic necrosis in association with hycanthone.
Topics: Chemical and Drug Induced Liver Injury; Humans; Hycanthone; Necrosis; Nitroquinolines; Oxamniquine; | 1978 |
Detection of antibodies by enzyme-immunoassay in human schistosoma mansoni infections: a clinical and chemotherapeutic study.
Topics: Adult; Antibodies; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Humans; Hycanthone; | 1978 |
Progress of the control of urinary schistosomiasis among school-children in Iraq by selective mass treatment campaign with etrenol in the last four school years (1973 - 1974 - 1976 - 1977).
Topics: Child; Communicable Disease Control; Female; Humans; Hycanthone; Male; National Health Programs; Sch | 1978 |
Carcinogenic potential of hycanthone in mice and hamsters.
Topics: Animals; Carcinogens; Chemical Phenomena; Chemistry; Cricetinae; Female; Hycanthone; Hyperplasia; In | 1979 |
Activity of known antischistosomal agents on early-developing forms of Schistosoma mansoni.
Topics: Animals; Antimony; Diethylamines; Edetic Acid; Hycanthone; Lithium; Lucanthone; Mice; Oxamniquine; S | 1975 |
Comparative effects of hycanthone in Schistosoma mansoni and Schistosoma japonicum.
Topics: Acetylcholine; Animals; Dansyl Compounds; Drug Antagonism; Drug Resistance; Hycanthone; Male; Mice; | 1977 |
Control of Schistosoma mansoni transmission by chemotherapy in St. Lucia. I. Results in man.
Topics: Adolescent; Adult; Child; Child, Preschool; Costs and Cost Analysis; Female; Humans; Hycanthone; Inf | 1977 |
Hycanthone dose-response in treatment of schistosomiasis mansoni in St. Lucia.
Topics: Adolescent; Adult; Child; Child, Preschool; Dose-Response Relationship, Drug; Feces; Female; Humans; | 1976 |
Hycanthone in the treatment of Egyptian bilharzial patients.
Topics: Adult; Child; Drug Administration Schedule; Egypt; Female; Humans; Hycanthone; Male; Middle Aged; Sc | 1976 |
Hycanthone in experimental schistosomiasis studies on liver pathology in mice treated with one and two doses.
Topics: Animals; Female; Hycanthone; Liver; Mice; Schistosoma mansoni; Schistosomiasis; Thioxanthenes | 1976 |
Targeted mass treatment: a new approach to the control of schistosomiasis.
Topics: Adolescent; Animals; Disease Vectors; Dose-Response Relationship, Drug; Feces; Humans; Hycanthone; K | 1976 |
[Treatment of schistosomiasis using hycanthone in 246 children. Side effects, laboratory studies and efficacy of various doses].
Topics: Adolescent; Age Factors; Body Weight; Child; Drug Evaluation; Female; Humans; Hycanthone; Male; Schi | 1975 |
[Experience with hycanthone in 3,100 carriers of schistosomiasis mansoni].
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Female; Humans; Hycanthone; Infant; Male; Middle A | 1976 |
Acute and early chronic phases of schistosomiasis mansoni in children treated with hycanthone.
Topics: Acute Disease; Adolescent; Child; Chronic Disease; Drug Evaluation; Female; Humans; Hycanthone; Male | 1975 |
Clinically available antischistosomal drugs.
Topics: Antimony; Humans; Hycanthone; Lucanthone; Niridazole; Schistosomiasis; Schistosomicides; Trichlorfon | 1975 |
A study of chromosomes of lymphocytes from patients treated with hycanthone.
Topics: Cells, Cultured; Chromatids; Chromosome Aberrations; Chromosomes; Humans; Hycanthone; Lymphocytes; M | 1975 |
[Letter: 3 deaths following administration of hycanthone (Etrenol)].
Topics: Chemical and Drug Induced Liver Injury; Child; Female; Humans; Hycanthone; Male; Schistosomiasis; So | 1976 |
Absence of liver toxicity in 2723 patients treated with hycanthone in St. Lucia.
Topics: Chemical and Drug Induced Liver Injury; Humans; Hycanthone; Schistosomiasis; Thioxanthenes; West Ind | 1976 |
Experimental chemotherapy of Schistosoma curassoni in mice.
Topics: Animals; Disease Models, Animal; Female; Hycanthone; Male; Mice; Nitroquinolines; Oxamniquine; Prazi | 1989 |
Hycanthone: a review of its experimental chemotherapy, pharmacology and toxicology.
Topics: Animals; Cats; Cricetinae; Dogs; Drug Tolerance; Female; Haplorhini; Humans; Hycanthone; Male; Mice; | 1974 |
Experiences with hycanthone methanesulfonate (etrenol) in the treatment of S. mansoni.
Topics: Child; Child, Preschool; Female; Humans; Hycanthone; Male; Mesylates; Schistosoma mansoni; Schistoso | 1974 |
Therapeutic evaluation of hycanthone in school children in rural endemic area in Egypt.
Topics: Adolescent; Age Factors; Child; Drug Evaluation; Egypt; Environmental Exposure; Ethylenediamines; Fe | 1974 |
Clinical trials of hycanthone in schistosomiasis mansoni in St. Lucia.
Topics: Abdomen; Adolescent; Anorexia; Child, Preschool; Humans; Hycanthone; Infant; Nausea; Pain; Schistoso | 1974 |
Observations on the use of hycanthone in a split dosage in the treatment of Schistosomiasis mansoni.
Topics: Child; Humans; Hycanthone; Injections, Intramuscular; Schistosoma mansoni; Schistosomiasis; Thioxant | 1974 |
Parenteral hycanthone sulfamate in the treatment of bilharziasis.
Topics: Adolescent; Adult; Amines; Ethylamines; Female; Humans; Hycanthone; Injections, Intramuscular; Male; | 1970 |