hycanthone has been researched along with Abnormalities, Autosome in 10 studies
Hycanthone: Potentially toxic, but effective antischistosomal agent, it is a metabolite of LUCANTHONE.
hycanthone : A thioxanthen-9-one compound having a hydroxymethyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. It was formerly used (particularly as the monomethanesulfonic acid salt) as a schistosomicide for individual or mass treatement of infection with Schistosoma haematobium and S. mansoni, but due to its toxicity and concern about possible carcinogenicity, it has been replaced by other drugs such as praziquantel.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chromosome abnormalities were present in cells from 12% (7/60) of the UC colonies, but there was no apparent relationship between colony diameter and the presence of chromosomal abnormalities." | 1.28 | Chromosome analysis of small and large L5178Y mouse lymphoma cell colonies: comparison of trifluorothymidine-resistant and unselected cell colonies from mutagen-treated and control cultures. ( Blazak, WF; Caspary, WJ; Los, FJ; Rudd, CJ, 1989) |
| "Gross chromosomal aberrations were assessed in human leucocyte cultures and in bone marrow preparations from drug-treated mice." | 1.25 | A comparative study on the genetic effects of hycanthone and oxamniquine. ( Ellis, JH; Holden, HE; Hyneck, ML; Ray, VA, 1975) |
| "The frequency of cells presenting chromosome abnormalities was determined in patients with schistosomiasis before and after treatment with a single dose of 2." | 1.25 | A study of chromosomes of lymphocytes from patients treated with hycanthone. ( Chamone, DA; Da Silva, LC; Ferreira, NR; Frota-Pessoa, O; Moro, AM; Otto, PA; Pedroso, MB, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sognier, MA | 2 |
| Hittelman, WN | 2 |
| Rao, PN | 1 |
| Ong, TM | 1 |
| Connor, TH | 1 |
| Meyne, J | 1 |
| Molina, L | 1 |
| Legator, MS | 1 |
| Bishun, N | 1 |
| Smith, N | 1 |
| Williams, D | 1 |
| Léonard, A | 1 |
| Ray, VA | 1 |
| Holden, HE | 1 |
| Ellis, JH | 1 |
| Hyneck, ML | 1 |
| Frota-Pessoa, O | 1 |
| Ferreira, NR | 1 |
| Pedroso, MB | 1 |
| Moro, AM | 1 |
| Otto, PA | 1 |
| Chamone, DA | 1 |
| Da Silva, LC | 1 |
| Blazak, WF | 2 |
| Los, FJ | 1 |
| Rudd, CJ | 2 |
| Caspary, WJ | 2 |
| Stewart, BE | 1 |
| Galperin, I | 1 |
| Allen, KL | 1 |
| Mitchell, AD | 1 |
1 review available for hycanthone and Abnormalities, Autosome
| Article | Year |
|---|---|
Genetic activities of hycanthone and some other antischistosomal drugs.
Topics: Acrylamides; Animals; Carcinogens; Chromosome Aberrations; Chromosomes; Drosophila; Genes, Dominant; | 1978 |
9 other studies available for hycanthone and Abnormalities, Autosome
| Article | Year |
|---|---|
Effect of DNA repair inhibitors on the induction and repair of bleomycin-induced chromosome damage.
Topics: Animals; Bleomycin; Cells, Cultured; Chromatids; Chromosome Aberrations; Chromosomes; Cricetinae; Cr | 1979 |
The repair of bleomycin-induced DNA damage and its relationship to chromosome aberration repair.
Topics: Animals; Anti-Bacterial Agents; Bleomycin; Cell Line; Chromosome Aberrations; Chromosomes; Cricetina | 1979 |
A combined testing protocol approach for mutagenicity testing.
Topics: Animals; Cell Nucleus; Chromosome Aberrations; Drug Evaluation, Preclinical; Female; Genetic Techniq | 1979 |
Mutations, chromosome aberrations and cancer.
Topics: Animals; Carcinogens, Environmental; Chemical Industry; Chromosome Aberrations; Cocarcinogenesis; Co | 1978 |
Heritable chromosome aberrations in mammals after exposure to chemicals.
Topics: Aflatoxins; Alkylating Agents; Aminoquinolines; Animals; Antimalarials; beta-Aminoethyl Isothiourea; | 1976 |
A comparative study on the genetic effects of hycanthone and oxamniquine.
Topics: Animals; Biological Assay; Bone Marrow; Bone Marrow Cells; Cells, Cultured; Chromosome Aberrations; | 1975 |
A study of chromosomes of lymphocytes from patients treated with hycanthone.
Topics: Cells, Cultured; Chromatids; Chromosome Aberrations; Chromosomes; Humans; Hycanthone; Lymphocytes; M | 1975 |
Chromosome analysis of small and large L5178Y mouse lymphoma cell colonies: comparison of trifluorothymidine-resistant and unselected cell colonies from mutagen-treated and control cultures.
Topics: Animals; Chromosome Aberrations; Dimethyl Sulfoxide; Hycanthone; Leukemia L5178; Leukemia, Experimen | 1989 |
Stable dicentric chromosomes induced by chemical mutagens in L5178Y mouse lymphoma cells.
Topics: Acrolein; Anaphase; Animals; Cells, Cultured; Chromosome Aberrations; Hycanthone; Karyotyping; Leuke | 1986 |