huperzine a has been researched along with Sensitivity and Specificity in 8 studies
huperzine A: RN given refers to 5R-(5alpha,9beta,11E)-isomer; structure given in first source
huperzine A : A sesquiterpene alkaloid isolated from a club moss Huperzia serrata that has been shown to exhibit neuroprotective activity. It is also an effective inhibitor of acetylcholinesterase and has attracted interest as a therapeutic candidate for Alzheimer's disease.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " The method facilitated a clinical pharmacokinetic study after oral administration of a single dose of matrine soft gelatin capsules (100, 200 and 400mg) in a three-period crossover design." | 1.35 | Matrine determination and pharmacokinetics in human plasma using LC/MS/MS. ( Chen, WL; Chu, NN; Li, XN; Liu, GY; Xu, HR; Yu, C; Zhang, XL, 2009) |
| "Huperzine A is a potent, reversible acetylcholinesterase inhibitor." | 1.34 | Simple determination of huperzine A in human plasma by liquid chromatographic-tandem mass spectrometric method. ( Jiang, XH; Lan, K; Li, YX; Wang, L, 2007) |
| "Huperzine A was found to be stable for at least 5h at RT and 1 week at -20 degrees C." | 1.34 | Determination of Huperzine A in rat plasma by high-performance liquid chromatography with a fluorescence detector. ( Chai, X; Ren, J; Tao, T; Yue, P; Zhao, Y, 2007) |
| "Huperzine A was dissolved in 0." | 1.33 | Application of L-Amino acid in determination of Huperzine A by high performance liquid chromatography. ( Hu, X; Jin, R; Pan, J, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhou, JL | 1 |
| An, JJ | 1 |
| Li, P | 1 |
| Li, HJ | 1 |
| Jiang, Y | 1 |
| Cheng, JF | 1 |
| Zhang, XL | 1 |
| Xu, HR | 1 |
| Chen, WL | 1 |
| Chu, NN | 1 |
| Li, XN | 1 |
| Liu, GY | 1 |
| Yu, C | 1 |
| Wang, Y | 1 |
| Chu, D | 1 |
| Gu, J | 1 |
| Fawcett, JP | 1 |
| Wu, Y | 1 |
| Liu, W | 1 |
| Ye, J | 1 |
| Zeng, S | 1 |
| Zhang, W | 1 |
| Chen, G | 1 |
| Ma, X | 1 |
| Tan, C | 1 |
| Zhu, D | 1 |
| Gang, DR | 1 |
| Pan, J | 1 |
| Jin, R | 1 |
| Hu, X | 1 |
| Li, YX | 1 |
| Jiang, XH | 1 |
| Lan, K | 1 |
| Wang, L | 1 |
| Yue, P | 1 |
| Tao, T | 1 |
| Zhao, Y | 1 |
| Ren, J | 1 |
| Chai, X | 1 |
8 other studies available for huperzine a and Sensitivity and Specificity
| Article | Year |
|---|---|
Two-dimensional turbulent flow chromatography coupled on-line to liquid chromatography-mass spectrometry for solution-based ligand screening against multiple proteins.
Topics: Acetylcholinesterase; Alkaloids; Butyrylcholinesterase; Cholinesterase Inhibitors; Cholinesterases; | 2009 |
Matrine determination and pharmacokinetics in human plasma using LC/MS/MS.
Topics: Alkaloids; Area Under Curve; Calibration; Chromatography, Liquid; Drug Stability; Humans; Least-Squa | 2009 |
Liquid chromatographic-tandem mass spectrometric method for the quantitation of huperzine A in dog plasma.
Topics: Alkaloids; Animals; Dogs; Mass Spectrometry; Neuroprotective Agents; Reproducibility of Results; Sen | 2004 |
Ion-pair reverse-phase high performance liquid chromatography method for determination of Huperzine-A in beagle dog serum.
Topics: Alkaloids; Animals; Cholinesterase Inhibitors; Dogs; Reference Standards; Reproducibility of Results | 2005 |
Is there a better source of huperzine A than Huperzia serrata? Huperzine A content of Huperziaceae species in China.
Topics: Alkaloids; China; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Humidity; Huperzi | 2005 |
Application of L-Amino acid in determination of Huperzine A by high performance liquid chromatography.
Topics: Alkaloids; Amino Acids; Chromatography, High Pressure Liquid; Reference Standards; Sensitivity and S | 2006 |
Simple determination of huperzine A in human plasma by liquid chromatographic-tandem mass spectrometric method.
Topics: Alkaloids; Chromatography, High Pressure Liquid; Humans; Huperzia; Mass Spectrometry; Molecular Stru | 2007 |
Determination of Huperzine A in rat plasma by high-performance liquid chromatography with a fluorescence detector.
Topics: Absorption; Administration, Intranasal; Alkaloids; Animals; Calibration; Chromatography, High Pressu | 2007 |