huperzine a has been researched along with Poisoning in 6 studies
huperzine A: RN given refers to 5R-(5alpha,9beta,11E)-isomer; structure given in first source
huperzine A : A sesquiterpene alkaloid isolated from a club moss Huperzia serrata that has been shown to exhibit neuroprotective activity. It is also an effective inhibitor of acetylcholinesterase and has attracted interest as a therapeutic candidate for Alzheimer's disease.
Poisoning: Used with drugs, chemicals, and industrial materials for human or animal poisoning, acute or chronic, whether the poisoning is accidental, occupational, suicidal, by medication error, or by environmental exposure.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Huperzine A is a potent, reversible red cells acetylcholinesterases (AChE) inhibitor, which shows high specificity for AChE preserving scavenger capacity of plasma butyrylcholinesterase (BuChE) for OP agents, and cross the blood-brain barrier smoothly preventing the AChE in CNS, so the CNS damages induced by the acute OP poisoning were prevented." | 6.43 | [Advances on study of organophosphate poisoning prevented by Huperzine A]. ( Liu, L; Sun, JX, 2005) |
| "Galantamine, a centrally acting cholinesterase (ChE) inhibitor and a nicotinic allosteric potentiating ligand used to treat Alzheimer's disease, is an effective and safe antidote against poisoning with nerve agents, including soman." | 3.75 | Effectiveness of donepezil, rivastigmine, and (+/-)huperzine A in counteracting the acute toxicity of organophosphorus nerve agents: comparison with galantamine. ( Adler, M; Akkerman, M; Albuquerque, EX; Aracava, Y; Pereira, EF, 2009) |
| "Huperzine A is a potent, reversible red cells acetylcholinesterases (AChE) inhibitor, which shows high specificity for AChE preserving scavenger capacity of plasma butyrylcholinesterase (BuChE) for OP agents, and cross the blood-brain barrier smoothly preventing the AChE in CNS, so the CNS damages induced by the acute OP poisoning were prevented." | 2.43 | [Advances on study of organophosphate poisoning prevented by Huperzine A]. ( Liu, L; Sun, JX, 2005) |
| "Huperzine A (HUP) is a naturally-occurring, potent, reversible inhibitor of acetylcholinesterase (AChE) that crosses the blood-brain barrier." | 1.29 | Huperzine A as a pretreatment candidate drug against nerve agent toxicity. ( Ashani, Y; Doctor, BP; Grunwald, J; Raveh, L, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 5 (83.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aracava, Y | 2 |
| Pereira, EF | 2 |
| Akkerman, M | 1 |
| Adler, M | 2 |
| Albuquerque, EX | 2 |
| Liu, L | 2 |
| Sun, JX | 2 |
| Xie, GY | 1 |
| Wang, J | 1 |
| Fawcett, WP | 1 |
| Oliveira, M | 1 |
| Randall, WR | 1 |
| Hamilton, TA | 1 |
| Kan, RK | 1 |
| Romano, JA | 1 |
| Grunwald, J | 1 |
| Raveh, L | 1 |
| Doctor, BP | 1 |
| Ashani, Y | 1 |
| Lallement, G | 1 |
1 review available for huperzine a and Poisoning
| Article | Year |
|---|---|
[Advances on study of organophosphate poisoning prevented by Huperzine A].
Topics: Acetylcholinesterase; Alkaloids; Animals; Cholinesterase Inhibitors; Guinea Pigs; Macaca mulatta; Mi | 2005 |
5 other studies available for huperzine a and Poisoning
| Article | Year |
|---|---|
Effectiveness of donepezil, rivastigmine, and (+/-)huperzine A in counteracting the acute toxicity of organophosphorus nerve agents: comparison with galantamine.
Topics: Acetylcholinesterase; Alkaloids; Animals; Antidotes; Chemical Warfare Agents; Donepezil; Dose-Respon | 2009 |
[Experimental study on protective effects of HupA in the treatment of isocarbophos poisoning].
Topics: Acetylcholinesterase; Alkaloids; Animals; Brain; Cholinesterase Inhibitors; Insecticides; Malathion; | 2006 |
Effective countermeasure against poisoning by organophosphorus insecticides and nerve agents.
Topics: Acetylcholinesterase; Alkaloids; Animals; Atropine; Behavior, Animal; Brain; Chemical Warfare Agents | 2006 |
Huperzine A as a pretreatment candidate drug against nerve agent toxicity.
Topics: Acetylcholinesterase; Alkaloids; Animals; Antidotes; Binding Sites; Brain; Cholinesterase Inhibitors | 1994 |
[Pretreatment of organophosphate poisoning: potential interests of huperzine A].
Topics: Alkaloids; Antidotes; Cholinesterase Inhibitors; Humans; Organophosphate Poisoning; Organophosphorus | 2000 |