huperzine a has been researched along with Organophosphate Poisoning in 5 studies
huperzine A: RN given refers to 5R-(5alpha,9beta,11E)-isomer; structure given in first source
huperzine A : A sesquiterpene alkaloid isolated from a club moss Huperzia serrata that has been shown to exhibit neuroprotective activity. It is also an effective inhibitor of acetylcholinesterase and has attracted interest as a therapeutic candidate for Alzheimer's disease.
Organophosphate Poisoning: Poisoning due to exposure to ORGANOPHOSPHORUS COMPOUNDS, such as ORGANOPHOSPHATES; ORGANOTHIOPHOSPHATES; and ORGANOTHIOPHOSPHONATES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Huperzine A is a potent, reversible red cells acetylcholinesterases (AChE) inhibitor, which shows high specificity for AChE preserving scavenger capacity of plasma butyrylcholinesterase (BuChE) for OP agents, and cross the blood-brain barrier smoothly preventing the AChE in CNS, so the CNS damages induced by the acute OP poisoning were prevented." | 6.43 | [Advances on study of organophosphate poisoning prevented by Huperzine A]. ( Liu, L; Sun, JX, 2005) |
| "Huperzine A is a potent, reversible red cells acetylcholinesterases (AChE) inhibitor, which shows high specificity for AChE preserving scavenger capacity of plasma butyrylcholinesterase (BuChE) for OP agents, and cross the blood-brain barrier smoothly preventing the AChE in CNS, so the CNS damages induced by the acute OP poisoning were prevented." | 2.43 | [Advances on study of organophosphate poisoning prevented by Huperzine A]. ( Liu, L; Sun, JX, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (80.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, L | 2 |
| Wang, J | 1 |
| Xie, G | 1 |
| Sun, J | 1 |
| Lallement, G | 2 |
| Baille, V | 1 |
| Baubichon, D | 1 |
| Carpentier, P | 1 |
| Collombet, JM | 1 |
| Filliat, P | 1 |
| Foquin, A | 1 |
| Four, E | 1 |
| Masqueliez, C | 1 |
| Testylier, G | 1 |
| Tonduli, L | 1 |
| Dorandeu, F | 1 |
| Sun, JX | 1 |
| Albuquerque, EX | 1 |
| Pereira, EF | 1 |
| Aracava, Y | 1 |
| Fawcett, WP | 1 |
| Oliveira, M | 1 |
| Randall, WR | 1 |
| Hamilton, TA | 1 |
| Kan, RK | 1 |
| Romano, JA | 1 |
| Adler, M | 1 |
2 reviews available for huperzine a and Organophosphate Poisoning
| Article | Year |
|---|---|
Review of the value of huperzine as pretreatment of organophosphate poisoning.
Topics: Alkaloids; Animals; Chemical Warfare Agents; Cholinesterase Inhibitors; Humans; Organophosphate Pois | 2002 |
[Advances on study of organophosphate poisoning prevented by Huperzine A].
Topics: Acetylcholinesterase; Alkaloids; Animals; Cholinesterase Inhibitors; Guinea Pigs; Macaca mulatta; Mi | 2005 |
3 other studies available for huperzine a and Organophosphate Poisoning
| Article | Year |
|---|---|
[Effect of Huperzine A on neural lesion of acute organophosphate poisoning in mice].
Topics: Alkaloids; Animals; Brain; Glutamic Acid; Malathion; Male; Mice; Neuroprotective Agents; Nitric Oxid | 2013 |
Effective countermeasure against poisoning by organophosphorus insecticides and nerve agents.
Topics: Acetylcholinesterase; Alkaloids; Animals; Atropine; Behavior, Animal; Brain; Chemical Warfare Agents | 2006 |
[Pretreatment of organophosphate poisoning: potential interests of huperzine A].
Topics: Alkaloids; Antidotes; Cholinesterase Inhibitors; Humans; Organophosphate Poisoning; Organophosphorus | 2000 |