huperzine a has been researched along with Neuroblastoma in 7 studies
huperzine A: RN given refers to 5R-(5alpha,9beta,11E)-isomer; structure given in first source
huperzine A : A sesquiterpene alkaloid isolated from a club moss Huperzia serrata that has been shown to exhibit neuroprotective activity. It is also an effective inhibitor of acetylcholinesterase and has attracted interest as a therapeutic candidate for Alzheimer's disease.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| " We investigated the effects of the acetylcholinesterase inhibitor, huperzine A (Hup A), on APP processing and Abeta generation in human neuroblastoma SK-N-SH cells overexpressing wild-type human APP695." | 7.74 | Huperzine A regulates amyloid precursor protein processing via protein kinase C and mitogen-activated protein kinase pathways in neuroblastoma SK-N-SH cells over-expressing wild type human amyloid precursor protein 695. ( Jiang, L; Lee, DY; Lemere, CA; Ma, Z; Peng, Y; Schachter, SC, 2007) |
| "Alzheimer's disease is a worldwide metabolic disease and an economically costly disease to society, so more medicines need to be developed to treat this disease." | 5.39 | Quantitative proteomic analysis reveals the neuroprotective effects of huperzine A for amyloid beta treated neuroblastoma N2a cells. ( Fang, L; Jiang, H; Tao, Y; Yang, H; Yang, Y; Zhang, H; Zhou, H, 2013) |
| " We investigated the effects of the acetylcholinesterase inhibitor, huperzine A (Hup A), on APP processing and Abeta generation in human neuroblastoma SK-N-SH cells overexpressing wild-type human APP695." | 3.74 | Huperzine A regulates amyloid precursor protein processing via protein kinase C and mitogen-activated protein kinase pathways in neuroblastoma SK-N-SH cells over-expressing wild type human amyloid precursor protein 695. ( Jiang, L; Lee, DY; Lemere, CA; Ma, Z; Peng, Y; Schachter, SC, 2007) |
| "Alzheimer's disease is a worldwide metabolic disease and an economically costly disease to society, so more medicines need to be developed to treat this disease." | 1.39 | Quantitative proteomic analysis reveals the neuroprotective effects of huperzine A for amyloid beta treated neuroblastoma N2a cells. ( Fang, L; Jiang, H; Tao, Y; Yang, H; Yang, Y; Zhang, H; Zhou, H, 2013) |
| "Huperzine A (HupA) is a reversible and selective inhibitor of acetylcholinesterase (AChE), and it has multiple targets when used for Alzheimer's disease (AD) therapy." | 1.37 | Huperzine A activates Wnt/β-catenin signaling and enhances the nonamyloidogenic pathway in an Alzheimer transgenic mouse model. ( Teng, WP; Wang, CY; Wang, SL; Wang, T; Wang, ZY; Xie, JW; Zhao, BL; Zheng, W, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Dang, TK | 1 |
| Hong, SM | 1 |
| Dao, VT | 1 |
| Nguyen, DT | 1 |
| Nguyen, KV | 1 |
| Nguyen, HT | 1 |
| Ullah, S | 1 |
| Tran, HT | 1 |
| Kim, SY | 1 |
| Tao, Y | 1 |
| Fang, L | 1 |
| Yang, Y | 1 |
| Jiang, H | 1 |
| Yang, H | 1 |
| Zhang, H | 1 |
| Zhou, H | 1 |
| Wang, CY | 1 |
| Zheng, W | 1 |
| Wang, T | 1 |
| Xie, JW | 1 |
| Wang, SL | 1 |
| Zhao, BL | 1 |
| Teng, WP | 1 |
| Wang, ZY | 1 |
| Zhao, HW | 1 |
| Li, XY | 1 |
| Zhang, HY | 1 |
| Brimijoin, S | 1 |
| Tang, XC | 2 |
| Tang, LL | 1 |
| Wang, R | 1 |
| Peng, Y | 1 |
| Lee, DY | 1 |
| Jiang, L | 1 |
| Ma, Z | 1 |
| Schachter, SC | 1 |
| Lemere, CA | 1 |
7 other studies available for huperzine a and Neuroblastoma
| Article | Year |
|---|---|
Neuroprotective effects of total alkaloids fraction of Huperzia serrata on scopolamine-induced neurodegenerative animals.
Topics: Acetylcholinesterase; Alkaloids; Animals; Antioxidants; Humans; Huperzia; Mice; Neuroblastoma; Neuro | 2023 |
Quantitative proteomic analysis reveals the neuroprotective effects of huperzine A for amyloid beta treated neuroblastoma N2a cells.
Topics: Alkaloids; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Death; Databases, Protein; Down-R | 2013 |
Huperzine A activates Wnt/β-catenin signaling and enhances the nonamyloidogenic pathway in an Alzheimer transgenic mouse model.
Topics: Acetylcholinesterase; Alkaloids; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Prec | 2011 |
Ginkgolide A, B, and huperzine A inhibit nitric oxide-induced neurotoxicity.
Topics: Alkaloids; Apoptosis; Brain Neoplasms; Cell Division; Diterpenes; Flow Cytometry; Ginkgolides; Human | 2002 |
Apoptosis induced by beta-amyloid25-35 in acetylcholinesterase-overexpressing neuroblastoma cells.
Topics: Acetylcholinesterase; Alkaloids; Amyloid beta-Peptides; Animals; Apoptosis; Cell Survival; Cholinest | 2003 |
Huperzine A protects SHSY5Y neuroblastoma cells against oxidative stress damage via nerve growth factor production.
Topics: Alkaloids; Androstadienes; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Carbazol | 2005 |
Huperzine A regulates amyloid precursor protein processing via protein kinase C and mitogen-activated protein kinase pathways in neuroblastoma SK-N-SH cells over-expressing wild type human amyloid precursor protein 695.
Topics: ADAM Proteins; ADAM10 Protein; ADAM17 Protein; Alkaloids; Alzheimer Disease; Amyloid beta-Peptides; | 2007 |