huperzine a has been researched along with Memory Disorders in 13 studies
huperzine A: RN given refers to 5R-(5alpha,9beta,11E)-isomer; structure given in first source
huperzine A : A sesquiterpene alkaloid isolated from a club moss Huperzia serrata that has been shown to exhibit neuroprotective activity. It is also an effective inhibitor of acetylcholinesterase and has attracted interest as a therapeutic candidate for Alzheimer's disease.
Memory Disorders: Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory impairments are associated with DEMENTIA; CRANIOCEREBRAL TRAUMA; ENCEPHALITIS; ALCOHOLISM (see also ALCOHOL AMNESTIC DISORDER); SCHIZOPHRENIA; and other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Huperzine A is an alkaloid which was first isolated from Huperzia serrata (Thumb) Trev by Zhejiang Academy of Medical Sciences and Shanghai Institute of Materia Medica, Chinese Academy of Sciences." | 6.67 | [Drug evaluation of huperzine A in the treatment of senile memory disorders]. ( Han, YY; Ma, YX; Sang, GW; Tang, XC; Yang, RM; Zhang, CL; Zhang, RW; Zhang, YD, 1991) |
| "Huperzine A is an alkaloid which was first isolated from Huperzia serrata (Thumb) Trev by Zhejiang Academy of Medical Sciences and Shanghai Institute of Materia Medica, Chinese Academy of Sciences." | 2.67 | [Drug evaluation of huperzine A in the treatment of senile memory disorders]. ( Han, YY; Ma, YX; Sang, GW; Tang, XC; Yang, RM; Zhang, CL; Zhang, RW; Zhang, YD, 1991) |
| "harmala in learning and memory deficits of scopolamine-induced mice and elucidate the underlying mechanisms involved." | 1.51 | Ameliorative effect of deoxyvasicine on scopolamine-induced cognitive dysfunction by restoration of cholinergic function in mice. ( Cheng, X; Deng, G; Ding, W; Guan, H; Ju, Z; Li, S; Liu, W; Ma, C; Rong, X; Wang, C; Wang, Y; Wu, C, 2019) |
| "serrata extract exerts any effects in Alzheimer's disease (AD) models." | 1.42 | Japanese Huperzia serrata extract and the constituent, huperzine A, ameliorate the scopolamine-induced cognitive impairment in mice. ( Abe, N; Hara, H; Ishisaka, M; Ohba, T; Oyama, M; Shimazawa, M; Tabira, T; Tsuruma, K; Yoshino, Y, 2015) |
| " Furthermore, subcutaneous administration of Bis-Mep (10, 100 or 1000 ng/kg) significantly reversed the scopolamine-induced memory deficits in a typical bell-shaped dose-response manner." | 1.39 | Bis(9)-(-)-nor-meptazinol as a novel dual-binding AChEI potently ameliorates scopolamine-induced cognitive deficits in mice. ( Chen, HZ; Cui, Y; Ge, XX; Li, J; Liu, T; Qiu, ZB; Wang, H; Xia, Z; Xie, Q; Xu, J; Xu, JR; Zhang, WW, 2013) |
| "Huperzine A is an anticholinesterase and cognitive enhancer, which is able to alleviate the symptoms of memory dysfunction in the mouse." | 1.34 | Prolonged effects of poly(lactic-co-glycolic acid) microsphere-containing huperzine A on mouse memory dysfunction induced by scopolamine. ( Fu, F; Liu, J; Liu, K; Ma, H; Wang, C; Zhang, T, 2007) |
| "The ability of huperzine A to attenuate memory deficits and neuronal damage after ischemia might be beneficial in cerebrovascular type dementia." | 1.31 | Huperzine A attenuates cognitive deficits and hippocampal neuronal damage after transient global ischemia in gerbils. ( Tang, XC; Zhang, HY; Zhou, J, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (23.08) | 18.2507 |
| 2000's | 7 (53.85) | 29.6817 |
| 2010's | 3 (23.08) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Deng, G | 1 |
| Wu, C | 1 |
| Rong, X | 1 |
| Li, S | 1 |
| Ju, Z | 1 |
| Wang, Y | 1 |
| Ma, C | 1 |
| Ding, W | 1 |
| Guan, H | 1 |
| Cheng, X | 1 |
| Liu, W | 2 |
| Wang, C | 2 |
| Ohba, T | 1 |
| Yoshino, Y | 1 |
| Ishisaka, M | 1 |
| Abe, N | 1 |
| Tsuruma, K | 1 |
| Shimazawa, M | 1 |
| Oyama, M | 1 |
| Tabira, T | 1 |
| Hara, H | 1 |
| Liu, T | 1 |
| Xia, Z | 1 |
| Zhang, WW | 1 |
| Xu, JR | 1 |
| Ge, XX | 1 |
| Li, J | 2 |
| Cui, Y | 1 |
| Qiu, ZB | 1 |
| Xu, J | 1 |
| Xie, Q | 1 |
| Wang, H | 1 |
| Chen, HZ | 1 |
| Fan, Y | 1 |
| Hu, J | 1 |
| Yang, Z | 1 |
| Xin, X | 1 |
| Wang, J | 1 |
| Ding, J | 1 |
| Geng, M | 1 |
| Wang, ZF | 1 |
| Tang, LL | 1 |
| Yan, H | 1 |
| Wang, YJ | 1 |
| Tang, XC | 6 |
| Zhang, T | 1 |
| Ma, H | 1 |
| Liu, J | 1 |
| Fu, F | 1 |
| Liu, K | 1 |
| Chu, D | 1 |
| Tian, J | 1 |
| Li, Z | 1 |
| Li, Y | 1 |
| Zhi, QX | 1 |
| Yi, FH | 1 |
| XI, CT | 1 |
| Ye, JW | 2 |
| Cai, JX | 1 |
| Wang, LM | 1 |
| Shang, YZ | 1 |
| Wang, ZM | 1 |
| Wang, R | 1 |
| Zhang, HY | 2 |
| Zhou, J | 1 |
| Zhang, RW | 1 |
| Han, YY | 1 |
| Sang, GW | 1 |
| Zhang, YD | 1 |
| Ma, YX | 1 |
| Zhang, CL | 1 |
| Yang, RM | 1 |
1 trial available for huperzine a and Memory Disorders
| Article | Year |
|---|---|
[Drug evaluation of huperzine A in the treatment of senile memory disorders].
Topics: Aged; Alkaloids; Case-Control Studies; Cholinesterase Inhibitors; Dementia; Dementia, Multi-Infarct; | 1991 |
12 other studies available for huperzine a and Memory Disorders
| Article | Year |
|---|---|
Ameliorative effect of deoxyvasicine on scopolamine-induced cognitive dysfunction by restoration of cholinergic function in mice.
Topics: Acetylcholine; Alkaloids; Amnesia; Animals; Antioxidants; Brain-Derived Neurotrophic Factor; Choline | 2019 |
Japanese Huperzia serrata extract and the constituent, huperzine A, ameliorate the scopolamine-induced cognitive impairment in mice.
Topics: Acetylcholinesterase; Alkaloids; Alzheimer Disease; Animals; Butyrylcholinesterase; Cholinesterase I | 2015 |
Bis(9)-(-)-nor-meptazinol as a novel dual-binding AChEI potently ameliorates scopolamine-induced cognitive deficits in mice.
Topics: Acetylcholinesterase; Alkaloids; Alzheimer Disease; Animals; Brain; Cholinesterase Inhibitors; Cogni | 2013 |
Effect of acidic oligosaccharide sugar chain on scopolamine-induced memory impairment in rats and its related mechanisms.
Topics: Adenosine Triphosphatases; Alkaloids; Analysis of Variance; Aniline Compounds; Animals; Behavior, An | 2005 |
Effects of huperzine A on memory deficits and neurotrophic factors production after transient cerebral ischemia and reperfusion in mice.
Topics: Alkaloids; Animals; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Gene Expression Regulation; | 2006 |
Prolonged effects of poly(lactic-co-glycolic acid) microsphere-containing huperzine A on mouse memory dysfunction induced by scopolamine.
Topics: Acetylcholinesterase; Alkaloids; Animals; Avoidance Learning; Cerebral Cortex; Delayed-Action Prepar | 2007 |
Poly(lactic-co-glycolic acid) microspheres for the controlled release of huperzine A: in vitro and in vivo studies and the application in the treatment of the impaired memory of mice.
Topics: Alkaloids; Animals; Cholinesterase Inhibitors; Lactic Acid; Memory Disorders; Mice; Microspheres; Po | 2007 |
Huperzine A ameliorates the spatial working memory impairments induced by AF64A.
Topics: Alkaloids; Analysis of Variance; Animals; Aziridines; Choline; Cholinesterase Inhibitors; Injections | 1995 |
Improving effects of huperzine A on spatial working memory in aged monkeys and young adult monkeys with experimental cognitive impairment.
Topics: Aging; Alkaloids; Animals; Cholinesterase Inhibitors; Cognition Disorders; Conditioning, Operant; Dr | 1999 |
Huperzine A ameliorates the impaired memory of aged rat in the Morris water maze performance.
Topics: Aging; Alkaloids; Animals; Cholinesterase Inhibitors; Male; Maze Learning; Memory; Memory Disorders; | 2000 |
Huperzine A attenuates cognitive dysfunction and neuronal degeneration caused by beta-amyloid protein-(1-40) in rat.
Topics: Alkaloids; Amyloid beta-Peptides; Animals; Apoptosis; bcl-2-Associated X Protein; Cerebral Cortex; C | 2001 |
Huperzine A attenuates cognitive deficits and hippocampal neuronal damage after transient global ischemia in gerbils.
Topics: Acetylcholinesterase; Administration, Oral; Alkaloids; Animals; Choline O-Acetyltransferase; Cogniti | 2001 |