Page last updated: 2024-10-21

huperzine a and Epilepsy

huperzine a has been researched along with Epilepsy in 3 studies

huperzine A: RN given refers to 5R-(5alpha,9beta,11E)-isomer; structure given in first source
huperzine A : A sesquiterpene alkaloid isolated from a club moss Huperzia serrata that has been shown to exhibit neuroprotective activity. It is also an effective inhibitor of acetylcholinesterase and has attracted interest as a therapeutic candidate for Alzheimer's disease.

Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)

Research Excerpts

ExcerptRelevanceReference
"In this review, we examine recently approved epilepsy drugs based on natural product (NP) such as cannabidiol (CBD) and rapamycin, as well as NP-based epilepsy drug candidates still in clinical development, such as huperzine A."5.41Natural product-derived therapies for treating drug-resistant epilepsies: From ethnopharmacology to evidence-based medicine. ( Challal, S; Crawford, AD; Esguerra, CV; Langlois, M; Skalicka-Woźniak, K; Skiba, A; Wolfender, JL, 2023)
"Huperzine A (HupA) is an acetylcholinesterase (AChE) inhibitor extracted from Huperzia Serrata, a firmoss, which has been used for various diseases in traditional Chinese medicine for fever and inflammation."2.53Huperzine A as a neuroprotective and antiepileptic drug: a review of preclinical research. ( Damar, U; Gersner, R; Johnstone, JT; Rotenberg, A; Schachter, S, 2016)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (66.67)24.3611
2020's1 (33.33)2.80

Authors

AuthorsStudies
Challal, S1
Skiba, A1
Langlois, M1
Esguerra, CV1
Wolfender, JL1
Crawford, AD1
Skalicka-Woźniak, K1
Damar, U2
Gersner, R2
Johnstone, JT2
Schachter, S2
Rotenberg, A2

Reviews

2 reviews available for huperzine a and Epilepsy

ArticleYear
Natural product-derived therapies for treating drug-resistant epilepsies: From ethnopharmacology to evidence-based medicine.
    Journal of ethnopharmacology, 2023, Dec-05, Volume: 317

    Topics: Animals; Anticonvulsants; Biological Products; Cannabidiol; Drug Resistant Epilepsy; Epilepsy; Ethno

2023
Huperzine A as a neuroprotective and antiepileptic drug: a review of preclinical research.
    Expert review of neurotherapeutics, 2016, Volume: 16, Issue:6

    Topics: Alkaloids; Animals; Anticonvulsants; Cholinesterase Inhibitors; Epilepsy; Humans; Neuroprotective Ag

2016

Other Studies

1 other study available for huperzine a and Epilepsy

ArticleYear
Huperzine A: A promising anticonvulsant, disease modifying, and memory enhancing treatment option in Alzheimer's disease.
    Medical hypotheses, 2017, Volume: 99

    Topics: Acetylcholinesterase; Alkaloids; Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetic

2017