huperzine a has been researched along with Dementia in 7 studies
huperzine A: RN given refers to 5R-(5alpha,9beta,11E)-isomer; structure given in first source
huperzine A : A sesquiterpene alkaloid isolated from a club moss Huperzia serrata that has been shown to exhibit neuroprotective activity. It is also an effective inhibitor of acetylcholinesterase and has attracted interest as a therapeutic candidate for Alzheimer's disease.
Dementia: An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.
| Excerpt | Relevance | Reference |
|---|---|---|
| " An overview of systematic reviews (SRs) was conducted to summarize the findings of SRs and meta-analyses on the effectiveness of Huperzine A (Hup A) in dementia and mild cognitive impairment (MCI)." | 9.12 | The effects of Huperzine A on dementia and mild cognitive impairment: An overview of systematic reviews. ( Dehghani Ahmadabad, A; Ghassab-Abdollahi, N; Mirghafourvand, M; Mobasseri, K; Nadrian, H, 2021) |
| "Huperzine A is an alkaloid which was first isolated from Huperzia serrata (Thumb) Trev by Zhejiang Academy of Medical Sciences and Shanghai Institute of Materia Medica, Chinese Academy of Sciences." | 6.67 | [Drug evaluation of huperzine A in the treatment of senile memory disorders]. ( Han, YY; Ma, YX; Sang, GW; Tang, XC; Yang, RM; Zhang, CL; Zhang, RW; Zhang, YD, 1991) |
| " An overview of systematic reviews (SRs) was conducted to summarize the findings of SRs and meta-analyses on the effectiveness of Huperzine A (Hup A) in dementia and mild cognitive impairment (MCI)." | 5.12 | The effects of Huperzine A on dementia and mild cognitive impairment: An overview of systematic reviews. ( Dehghani Ahmadabad, A; Ghassab-Abdollahi, N; Mirghafourvand, M; Mobasseri, K; Nadrian, H, 2021) |
| "Huperzine A is an alkaloid which was first isolated from Huperzia serrata (Thumb) Trev by Zhejiang Academy of Medical Sciences and Shanghai Institute of Materia Medica, Chinese Academy of Sciences." | 2.67 | [Drug evaluation of huperzine A in the treatment of senile memory disorders]. ( Han, YY; Ma, YX; Sang, GW; Tang, XC; Yang, RM; Zhang, CL; Zhang, RW; Zhang, YD, 1991) |
| "Huperzine A (HupA) is a selective inhibitor of acetylcholinesterase (AChE) and has been shown to significantly reduce cognitive impairment in animal models of dementia." | 1.39 | Huperzine A, but not tacrine, stimulates S100B secretion in astrocyte cultures. ( Abib, R; Gonçalves, CA; Guerra, MC; Leite, MC; Lunardi, P; Nardin, P, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Ghassab-Abdollahi, N | 1 |
| Mobasseri, K | 1 |
| Dehghani Ahmadabad, A | 1 |
| Nadrian, H | 1 |
| Mirghafourvand, M | 1 |
| Lunardi, P | 1 |
| Nardin, P | 1 |
| Guerra, MC | 1 |
| Abib, R | 1 |
| Leite, MC | 1 |
| Gonçalves, CA | 1 |
| Lyketsos, CG | 1 |
| Colenda, CC | 1 |
| Beck, C | 1 |
| Blank, K | 1 |
| Doraiswamy, MP | 1 |
| Kalunian, DA | 1 |
| Yaffe, K | 1 |
| Beier, MT | 1 |
| Fink, DM | 1 |
| Bores, GM | 1 |
| Effland, RC | 1 |
| Huger, FP | 1 |
| Kurys, BE | 1 |
| Rush, DK | 1 |
| Selk, DE | 1 |
| Chiu, HF | 1 |
| Zhang, M | 1 |
| Zhang, RW | 1 |
| Tang, XC | 1 |
| Han, YY | 1 |
| Sang, GW | 1 |
| Zhang, YD | 1 |
| Ma, YX | 1 |
| Zhang, CL | 1 |
| Yang, RM | 1 |
3 reviews available for huperzine a and Dementia
| Article | Year |
|---|---|
The effects of Huperzine A on dementia and mild cognitive impairment: An overview of systematic reviews.
Topics: Activities of Daily Living; Alkaloids; Alzheimer Disease; Cognitive Dysfunction; Dementia; Humans; Q | 2021 |
Harmless herbs? Think again: merits of a complete medication history.
Topics: Aged; Alkaloids; Cholinesterase Inhibitors; Dementia; Evidence-Based Medicine; Galantamine; Geriatri | 2006 |
Dementia research in China.
Topics: Alkaloids; Caregivers; China; Cross-Cultural Comparison; Dementia; Drug Evaluation; Epidemiologic St | 2000 |
1 trial available for huperzine a and Dementia
| Article | Year |
|---|---|
[Drug evaluation of huperzine A in the treatment of senile memory disorders].
Topics: Aged; Alkaloids; Case-Control Studies; Cholinesterase Inhibitors; Dementia; Dementia, Multi-Infarct; | 1991 |
3 other studies available for huperzine a and Dementia
| Article | Year |
|---|---|
Huperzine A, but not tacrine, stimulates S100B secretion in astrocyte cultures.
Topics: Alkaloids; Animals; Astrocytes; Cell Survival; Cells, Cultured; Cholinesterase Inhibitors; Dementia; | 2013 |
Position statement of the American Association for Geriatric Psychiatry regarding principles of care for patients with dementia resulting from Alzheimer disease.
Topics: Aged; Alkaloids; Alzheimer Disease; Brain; Caregivers; Cholinesterase Inhibitors; Cognition Disorder | 2006 |
Synthesis and evaluation of 5-amino-5,6,7,8-tetrahydroquinolinones as potential agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alkaloids; Alzheimer Disease; Aminoquinolines; Animals; Cholinesterase Inhibit | 1995 |