huperzine a has been researched along with Cognitive Decline in 6 studies
huperzine A: RN given refers to 5R-(5alpha,9beta,11E)-isomer; structure given in first source
huperzine A : A sesquiterpene alkaloid isolated from a club moss Huperzia serrata that has been shown to exhibit neuroprotective activity. It is also an effective inhibitor of acetylcholinesterase and has attracted interest as a therapeutic candidate for Alzheimer's disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| " An overview of systematic reviews (SRs) was conducted to summarize the findings of SRs and meta-analyses on the effectiveness of Huperzine A (Hup A) in dementia and mild cognitive impairment (MCI)." | 9.12 | The effects of Huperzine A on dementia and mild cognitive impairment: An overview of systematic reviews. ( Dehghani Ahmadabad, A; Ghassab-Abdollahi, N; Mirghafourvand, M; Mobasseri, K; Nadrian, H, 2021) |
| " An overview of systematic reviews (SRs) was conducted to summarize the findings of SRs and meta-analyses on the effectiveness of Huperzine A (Hup A) in dementia and mild cognitive impairment (MCI)." | 5.12 | The effects of Huperzine A on dementia and mild cognitive impairment: An overview of systematic reviews. ( Dehghani Ahmadabad, A; Ghassab-Abdollahi, N; Mirghafourvand, M; Mobasseri, K; Nadrian, H, 2021) |
| " Huperzine is safe with mild side effects." | 2.61 | [Efficacy and safety of huperzine A in treating patients with mild cognitive impairment: a systematic review and Meta-analysis]. ( Feng, S; Guo, YH; Hu, J; Huang, P; Li, B; Liu, QQ, 2019) |
| "harmala in learning and memory deficits of scopolamine-induced mice and elucidate the underlying mechanisms involved." | 1.51 | Ameliorative effect of deoxyvasicine on scopolamine-induced cognitive dysfunction by restoration of cholinergic function in mice. ( Cheng, X; Deng, G; Ding, W; Guan, H; Ju, Z; Li, S; Liu, W; Ma, C; Rong, X; Wang, C; Wang, Y; Wu, C, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 2 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Shih, CC | 1 |
| Chen, PY | 1 |
| Chen, MF | 1 |
| Lee, TJF | 1 |
| Ghassab-Abdollahi, N | 1 |
| Mobasseri, K | 1 |
| Dehghani Ahmadabad, A | 1 |
| Nadrian, H | 1 |
| Mirghafourvand, M | 1 |
| Gul, A | 1 |
| Bakht, J | 1 |
| Mehmood, F | 1 |
| Huang, P | 1 |
| Li, B | 1 |
| Guo, YH | 1 |
| Feng, S | 1 |
| Hu, J | 1 |
| Liu, QQ | 1 |
| Deng, G | 1 |
| Wu, C | 1 |
| Rong, X | 1 |
| Li, S | 1 |
| Ju, Z | 1 |
| Wang, Y | 1 |
| Ma, C | 1 |
| Ding, W | 1 |
| Guan, H | 1 |
| Cheng, X | 1 |
| Liu, W | 1 |
| Wang, C | 1 |
| Yue, J | 1 |
| Dong, BR | 1 |
| Lin, X | 1 |
| Yang, M | 1 |
| Wu, HM | 1 |
| Wu, T | 1 |
3 reviews available for huperzine a and Cognitive Decline
| Article | Year |
|---|---|
The effects of Huperzine A on dementia and mild cognitive impairment: An overview of systematic reviews.
Topics: Activities of Daily Living; Alkaloids; Alzheimer Disease; Cognitive Dysfunction; Dementia; Humans; Q | 2021 |
[Efficacy and safety of huperzine A in treating patients with mild cognitive impairment: a systematic review and Meta-analysis].
Topics: Alkaloids; Cognitive Dysfunction; Humans; Memory; Randomized Controlled Trials as Topic; Sesquiterpe | 2019 |
Huperzine A for mild cognitive impairment.
Topics: Alkaloids; Cholinesterase Inhibitors; Cognitive Dysfunction; Humans; Neuroprotective Agents; Sesquit | 2012 |
1 trial available for huperzine a and Cognitive Decline
| Article | Year |
|---|---|
Huperzine-A response to cognitive impairment and task switching deficits in patients with Alzheimer's disease.
Topics: Aged; Alkaloids; Alzheimer Disease; Cholinesterase Inhibitors; Cognitive Dysfunction; Double-Blind M | 2019 |
2 other studies available for huperzine a and Cognitive Decline
| Article | Year |
|---|---|
Differential blockade by huperzine A and donepezil of sympathetic nicotinic acetylcholine receptor-mediated nitrergic neurogenic dilations in porcine basilar arteries.
Topics: Alkaloids; Alzheimer Disease; Animals; Basilar Artery; Brain Stem; Calcium; Cholinesterase Inhibitor | 2020 |
Ameliorative effect of deoxyvasicine on scopolamine-induced cognitive dysfunction by restoration of cholinergic function in mice.
Topics: Acetylcholine; Alkaloids; Amnesia; Animals; Antioxidants; Brain-Derived Neurotrophic Factor; Choline | 2019 |