huperzine a has been researched along with Cognition Disorders in 18 studies
huperzine A: RN given refers to 5R-(5alpha,9beta,11E)-isomer; structure given in first source
huperzine A : A sesquiterpene alkaloid isolated from a club moss Huperzia serrata that has been shown to exhibit neuroprotective activity. It is also an effective inhibitor of acetylcholinesterase and has attracted interest as a therapeutic candidate for Alzheimer's disease.
Cognition Disorders: Disorders characterized by disturbances in mental processes related to learning, thinking, reasoning, and judgment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to examine the efficacy of huperzine A (HupA), an isolate of Huperzine serrata, in the treatment of cognitive deficits in schizophrenia spectrum disorders." | 8.93 | Adjunctive huperzine A for cognitive deficits in schizophrenia: a systematic review and meta-analysis. ( Chiu, HF; D'Arcy, C; Li, XB; Meng, X; Sun, F; Ungvari, GS; Xiang, YQ; Xiang, YT; Zheng, W, 2016) |
| "The aim of this study was to examine the efficacy of huperzine A (HupA), an isolate of Huperzine serrata, in the treatment of cognitive deficits in schizophrenia spectrum disorders." | 4.93 | Adjunctive huperzine A for cognitive deficits in schizophrenia: a systematic review and meta-analysis. ( Chiu, HF; D'Arcy, C; Li, XB; Meng, X; Sun, F; Ungvari, GS; Xiang, YQ; Xiang, YT; Zheng, W, 2016) |
| " To avoid these treatment complications but safely protect against DFP-induced seizures and other CNS toxicity, we adopted the strategy of administering mice with (i) small doses of huperzine A (HUP), a reversible and long-lasting (half-life approximately 5 h) inhibitor of AChE, and (ii) imidazenil (IMI), a potent positive allosteric modulator of GABA action selective for alpha(5)-containing GABA(A) receptors." | 3.74 | The combination of huperzine A and imidazenil is an effective strategy to prevent diisopropyl fluorophosphate toxicity in mice. ( Auta, J; Costa, E; Guidotti, A; Kadriu, B; Kozikowski, AP; Pibiri, F; Pinna, G, 2008) |
| "serrata extract exerts any effects in Alzheimer's disease (AD) models." | 1.42 | Japanese Huperzia serrata extract and the constituent, huperzine A, ameliorate the scopolamine-induced cognitive impairment in mice. ( Abe, N; Hara, H; Ishisaka, M; Ohba, T; Oyama, M; Shimazawa, M; Tabira, T; Tsuruma, K; Yoshino, Y, 2015) |
| "Huperzine A treatment significantly ameliorated all these phenomena." | 1.36 | Huperzine a improves chronic inflammation and cognitive decline in rats with cerebral hypoperfusion. ( Tang, XC; Wang, J; Zhang, HY, 2010) |
| "Huperzine A treatment (0." | 1.32 | [Huperzine A attenuates cognitive deficits and brain injury after hypoxia-ischemic brain damage in neonatal rats]. ( Shao, XM; Tang, XC; Wang, LS; Zhou, J, 2003) |
| "The ability of huperzine A to attenuate memory deficits and neuronal damage after ischemia might be beneficial in cerebrovascular type dementia." | 1.31 | Huperzine A attenuates cognitive deficits and hippocampal neuronal damage after transient global ischemia in gerbils. ( Tang, XC; Zhang, HY; Zhou, J, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.56) | 18.2507 |
| 2000's | 7 (38.89) | 29.6817 |
| 2010's | 9 (50.00) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| An, JR | 1 |
| Zhao, YS | 1 |
| Luo, LF | 1 |
| Guan, P | 1 |
| Tan, M | 1 |
| Ji, ES | 1 |
| Tabira, T | 2 |
| Kawamura, N | 1 |
| Ye, L | 1 |
| Fu, F | 1 |
| Liu, W | 1 |
| Sun, K | 1 |
| Li, Y | 1 |
| He, J | 1 |
| Yu, X | 1 |
| Yu, P | 1 |
| Tian, J | 1 |
| Mao, XY | 1 |
| Cao, DF | 1 |
| Li, X | 1 |
| Yin, JY | 1 |
| Wang, ZB | 1 |
| Zhang, Y | 1 |
| Mao, CX | 1 |
| Zhou, HH | 1 |
| Liu, ZQ | 1 |
| Ohba, T | 1 |
| Yoshino, Y | 1 |
| Ishisaka, M | 1 |
| Abe, N | 1 |
| Tsuruma, K | 1 |
| Shimazawa, M | 1 |
| Oyama, M | 1 |
| Hara, H | 1 |
| Zheng, W | 1 |
| Xiang, YQ | 1 |
| Li, XB | 1 |
| Ungvari, GS | 1 |
| Chiu, HF | 1 |
| Sun, F | 1 |
| D'Arcy, C | 1 |
| Meng, X | 1 |
| Xiang, YT | 1 |
| Damar, U | 1 |
| Gersner, R | 1 |
| Johnstone, JT | 1 |
| Schachter, S | 1 |
| Rotenberg, A | 1 |
| Pibiri, F | 1 |
| Kozikowski, AP | 1 |
| Pinna, G | 1 |
| Auta, J | 1 |
| Kadriu, B | 1 |
| Costa, E | 1 |
| Guidotti, A | 1 |
| Wang, J | 1 |
| Zhang, HY | 3 |
| Tang, XC | 6 |
| Ratia, M | 1 |
| Giménez-Llort, L | 1 |
| Camps, P | 1 |
| Muñoz-Torrero, D | 1 |
| Pérez, B | 1 |
| Clos, MV | 1 |
| Badia, A | 1 |
| Shi, Q | 1 |
| Fu, J | 1 |
| Ge, D | 1 |
| He, Y | 1 |
| Ran, J | 1 |
| Liu, Z | 1 |
| Wei, J | 1 |
| Diao, T | 1 |
| Lu, Y | 1 |
| Wang, LS | 1 |
| Zhou, J | 2 |
| Shao, XM | 1 |
| Xu, Z | 1 |
| Zheng, H | 1 |
| Law, SL | 1 |
| Dong So, D | 1 |
| Han, Y | 1 |
| Xue, H | 1 |
| Lyketsos, CG | 1 |
| Colenda, CC | 1 |
| Beck, C | 1 |
| Blank, K | 1 |
| Doraiswamy, MP | 1 |
| Kalunian, DA | 1 |
| Yaffe, K | 1 |
| Ye, JW | 1 |
| Cai, JX | 1 |
| Wang, LM | 2 |
| Han, YF | 1 |
| Wang, R | 1 |
1 review available for huperzine a and Cognition Disorders
| Article | Year |
|---|---|
Adjunctive huperzine A for cognitive deficits in schizophrenia: a systematic review and meta-analysis.
Topics: Alkaloids; Antipsychotic Agents; Cognition Disorders; Drug Therapy, Combination; Humans; Neuroprotec | 2016 |
17 other studies available for huperzine a and Cognition Disorders
| Article | Year |
|---|---|
Huperzine A, reduces brain iron overload and alleviates cognitive deficit in mice exposed to chronic intermittent hypoxia.
Topics: Alkaloids; Animals; Apoptosis; Behavior, Animal; Caspase 3; Cation Transport Proteins; Cognition Dis | 2020 |
A Study of a Supplement Containing Huperzine A and Curcumin in Dementia Patients and Individuals with Mild Cognitive Impairment.
Topics: Aged; Aged, 80 and over; Alkaloids; Biosimilar Pharmaceuticals; Cognition Disorders; Curcumin; Demen | 2018 |
Preparation and in vitro and in vivo evaluation of HupA PLGA microsphere.
Topics: Acetylcholinesterase; Administration, Oral; Alkaloids; Amyloid beta-Peptides; Animals; Behavior, Ani | 2013 |
Huperzine A ameliorates cognitive deficits in streptozotocin-induced diabetic rats.
Topics: Alkaloids; Animals; Blood Glucose; Body Weight; Brain-Derived Neurotrophic Factor; Caspase 3; Cognit | 2014 |
Japanese Huperzia serrata extract and the constituent, huperzine A, ameliorate the scopolamine-induced cognitive impairment in mice.
Topics: Acetylcholinesterase; Alkaloids; Alzheimer Disease; Animals; Butyrylcholinesterase; Cholinesterase I | 2015 |
Huperzine A: A promising anticonvulsant, disease modifying, and memory enhancing treatment option in Alzheimer's disease.
Topics: Acetylcholinesterase; Alkaloids; Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetic | 2017 |
The combination of huperzine A and imidazenil is an effective strategy to prevent diisopropyl fluorophosphate toxicity in mice.
Topics: Alkaloids; Animals; Benzodiazepines; Cognition Disorders; Drug Therapy, Combination; Imidazoles; Iso | 2008 |
Huperzine a improves chronic inflammation and cognitive decline in rats with cerebral hypoperfusion.
Topics: Alkaloids; Animals; Carotid Artery Diseases; CD11b Antigen; Cell Hypoxia; Cell- and Tissue-Based The | 2010 |
Huprine X and huperzine A improve cognition and regulate some neurochemical processes related with Alzheimer's disease in triple transgenic mice (3xTg-AD).
Topics: Alkaloids; Alzheimer Disease; Aminoquinolines; Animals; Brain Chemistry; Cerebral Cortex; Cognition | 2013 |
Huperzine A ameliorates cognitive deficits and oxidative stress in the hippocampus of rats exposed to acute hypobaric hypoxia.
Topics: Air Pressure; Alkaloids; Animals; Behavior, Animal; Biomarkers; Blotting, Western; Cognition Disorde | 2012 |
[Huperzine A attenuates cognitive deficits and brain injury after hypoxia-ischemic brain damage in neonatal rats].
Topics: Acetylcholinesterase; Alkaloids; Animals; Animals, Newborn; Cerebral Cortex; Cognition Disorders; Co | 2003 |
Effects of a memory enhancing peptide on cognitive abilities of brain-lesioned mice: additivity with huperzine A and relative potency to tacrine.
Topics: Alkaloids; Animals; Avoidance Learning; Behavior, Animal; Brain Diseases; Cognition Disorders; Disea | 2006 |
Position statement of the American Association for Geriatric Psychiatry regarding principles of care for patients with dementia resulting from Alzheimer disease.
Topics: Aged; Alkaloids; Alzheimer Disease; Brain; Caregivers; Cholinesterase Inhibitors; Cognition Disorder | 2006 |
Improving effects of huperzine A on spatial working memory in aged monkeys and young adult monkeys with experimental cognitive impairment.
Topics: Aging; Alkaloids; Animals; Cholinesterase Inhibitors; Cognition Disorders; Conditioning, Operant; Dr | 1999 |
Huperzine A improves cognitive deficits caused by chronic cerebral hypoperfusion in rats.
Topics: Acetylcholinesterase; Alkaloids; Animals; Brain; Brain Ischemia; Choline O-Acetyltransferase; Cholin | 2000 |
Huperzine A attenuates cognitive dysfunction and neuronal degeneration caused by beta-amyloid protein-(1-40) in rat.
Topics: Alkaloids; Amyloid beta-Peptides; Animals; Apoptosis; bcl-2-Associated X Protein; Cerebral Cortex; C | 2001 |
Huperzine A attenuates cognitive deficits and hippocampal neuronal damage after transient global ischemia in gerbils.
Topics: Acetylcholinesterase; Administration, Oral; Alkaloids; Animals; Choline O-Acetyltransferase; Cogniti | 2001 |