huperzine a has been researched along with Aging in 8 studies
huperzine A: RN given refers to 5R-(5alpha,9beta,11E)-isomer; structure given in first source
huperzine A : A sesquiterpene alkaloid isolated from a club moss Huperzia serrata that has been shown to exhibit neuroprotective activity. It is also an effective inhibitor of acetylcholinesterase and has attracted interest as a therapeutic candidate for Alzheimer's disease.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chronic administration of D-galactose (D-gal) results in oxidative stress and chronic inflammatory aging." | 3.80 | The neurovascular protective effects of huperzine A on D-galactose-induced inflammatory damage in the rat hippocampus. ( Ao, H; Bao, Z; Gao, Z; Hu, X; Kong, D; Liu, F; Ma, H; Ruan, Q; Yu, Z, 2014) |
| "Our preliminary results show that huperzine A, an acetylcholinesterase inhibitor used to treat Alzheimer's disease (AD) patients in China, exhibits different pharmacokinetic features in elderly and young healthy subjects." | 2.82 | Population pharmacokinetic modeling and simulation of huperzine A in elderly Chinese subjects. ( Hu, CY; Jia, JY; Li, XN; Liu, GY; Liu, Y; Lu, C; Qu, Y; Sheng, L; Wang, HY; Wang, WL; Wang, YJ; Xu, HR; Yan, J; Yu, C; Zhang, MQ, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ruan, Q | 2 |
| Hu, X | 2 |
| Ao, H | 1 |
| Ma, H | 1 |
| Gao, Z | 2 |
| Liu, F | 2 |
| Kong, D | 2 |
| Bao, Z | 2 |
| Yu, Z | 2 |
| Sheng, L | 1 |
| Qu, Y | 1 |
| Yan, J | 1 |
| Liu, GY | 1 |
| Wang, WL | 1 |
| Wang, YJ | 1 |
| Wang, HY | 1 |
| Zhang, MQ | 1 |
| Lu, C | 1 |
| Liu, Y | 1 |
| Jia, JY | 1 |
| Hu, CY | 1 |
| Li, XN | 1 |
| Yu, C | 1 |
| Xu, HR | 1 |
| Shi, D | 1 |
| Cheng, XR | 1 |
| Zhou, WX | 1 |
| Zhang, YX | 1 |
| Ye, JW | 3 |
| Cai, JX | 1 |
| Wang, LM | 1 |
| Tang, XC | 4 |
| Shang, YZ | 2 |
| Wang, ZM | 1 |
| Lu, WH | 1 |
| Shou, J | 1 |
1 trial available for huperzine a and Aging
| Article | Year |
|---|---|
Population pharmacokinetic modeling and simulation of huperzine A in elderly Chinese subjects.
Topics: Aged; Aged, 80 and over; Aging; Alkaloids; Asian People; Body Height; Body Weight; Creatinine; Femal | 2016 |
7 other studies available for huperzine a and Aging
| Article | Year |
|---|---|
The neurovascular protective effects of huperzine A on D-galactose-induced inflammatory damage in the rat hippocampus.
Topics: Aging; Alkaloids; Animals; Apoptosis; Blood-Brain Barrier; Cholinesterase Inhibitors; Cytokines; Enc | 2014 |
The anti-inflamm-aging and hepatoprotective effects of huperzine A in D-galactose-treated rats.
Topics: Aging; Alkaloids; Animals; Anti-Inflammatory Agents; Cellular Senescence; Cytokines; Galactose; Infl | 2013 |
The effects of Liuwei Dihuang decoction on the gene expression in the hippocampus of senescence-accelerated mouse.
Topics: Aging; Alkaloids; Alzheimer Disease; Animals; Cholinesterase Inhibitors; DNA, Complementary; Drugs, | 2007 |
Improving effects of huperzine A on spatial working memory in aged monkeys and young adult monkeys with experimental cognitive impairment.
Topics: Aging; Alkaloids; Animals; Cholinesterase Inhibitors; Cognition Disorders; Conditioning, Operant; Dr | 1999 |
Improving effects of huperzine A on abnormal lipid peroxidation and superoxide dismutase in aged rats.
Topics: Aging; Alkaloids; Animals; Cerebral Cortex; Cholinesterase Inhibitors; Free Radicals; Hippocampus; L | 1999 |
Huperzine A ameliorates the impaired memory of aged rat in the Morris water maze performance.
Topics: Aging; Alkaloids; Animals; Cholinesterase Inhibitors; Male; Maze Learning; Memory; Memory Disorders; | 2000 |
[Improving effect of huperzine A on discrimination performance in aged rats and adult rats with experimental cognitive impairment].
Topics: Aging; Alkaloids; Animals; Cholinesterase Inhibitors; Discrimination Learning; Female; Lighting; Mal | 1988 |