huperzine a has been researched along with Absence Seizure in 11 studies
huperzine A: RN given refers to 5R-(5alpha,9beta,11E)-isomer; structure given in first source
huperzine A : A sesquiterpene alkaloid isolated from a club moss Huperzia serrata that has been shown to exhibit neuroprotective activity. It is also an effective inhibitor of acetylcholinesterase and has attracted interest as a therapeutic candidate for Alzheimer's disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Since previous works suggested a capacity for HupA to prophylax against seizures, we tested the HupA antiepileptic potential in pentylenetetrazole (PTZ) rat epilepsy model and explored its mechanism of action by spectral EEG analysis and by paired-pulse transcranial magnetic stimulation (ppTMS), a measure of GABA-mediated intracortical inhibition." | 7.81 | Huperzine A prophylaxis against pentylenetetrazole-induced seizures in rats is associated with increased cortical inhibition. ( Dhamne, SC; Ekstein, D; Gersner, R; Rotenberg, A; Schachter, SC, 2015) |
| " We tested, in vivo, its efficiency in protecting cortical AChE from soman inhibition and preventing subsequent seizures." | 7.71 | Effects of Huperzine used as pre-treatment against soman-induced seizures. ( Lallement, G; Masqueliez, C; Monmaur, P; Testylier, G; Tonduli, LS, 2001) |
| " Its ability to prevent seizures and subsequent hippocampal neuropathological changes induced by the organophosphate soman was studied in guinea pigs." | 7.69 | Efficacy of huperzine in preventing soman-induced seizures, neuropathological changes and lethality. ( Aubriot, S; Baubichon, D; Burckhart, MF; Lallement, G; Masqueliez, C; Veyret, J, 1997) |
| "EAAs sustain seizure activity and induce neuropathology due to over-stimulation of N-methyl-d-aspartate (NMDA) receptors." | 5.35 | [+]-Huperzine A treatment protects against N-methyl-D-aspartate-induced seizure/status epilepticus in rats. ( Coleman, BR; Doctor, BP; Gordon, RK; Nambiar, MP; Oguntayo, SA; Ratcliffe, RH; Shi, X, 2008) |
| " Since previous works suggested a capacity for HupA to prophylax against seizures, we tested the HupA antiepileptic potential in pentylenetetrazole (PTZ) rat epilepsy model and explored its mechanism of action by spectral EEG analysis and by paired-pulse transcranial magnetic stimulation (ppTMS), a measure of GABA-mediated intracortical inhibition." | 3.81 | Huperzine A prophylaxis against pentylenetetrazole-induced seizures in rats is associated with increased cortical inhibition. ( Dhamne, SC; Ekstein, D; Gersner, R; Rotenberg, A; Schachter, SC, 2015) |
| " To avoid these treatment complications but safely protect against DFP-induced seizures and other CNS toxicity, we adopted the strategy of administering mice with (i) small doses of huperzine A (HUP), a reversible and long-lasting (half-life approximately 5 h) inhibitor of AChE, and (ii) imidazenil (IMI), a potent positive allosteric modulator of GABA action selective for alpha(5)-containing GABA(A) receptors." | 3.74 | The combination of huperzine A and imidazenil is an effective strategy to prevent diisopropyl fluorophosphate toxicity in mice. ( Auta, J; Costa, E; Guidotti, A; Kadriu, B; Kozikowski, AP; Pibiri, F; Pinna, G, 2008) |
| " We tested, in vivo, its efficiency in protecting cortical AChE from soman inhibition and preventing subsequent seizures." | 3.71 | Effects of Huperzine used as pre-treatment against soman-induced seizures. ( Lallement, G; Masqueliez, C; Monmaur, P; Testylier, G; Tonduli, LS, 2001) |
| " Its ability to prevent seizures and subsequent hippocampal neuropathological changes induced by the organophosphate soman was studied in guinea pigs." | 3.69 | Efficacy of huperzine in preventing soman-induced seizures, neuropathological changes and lethality. ( Aubriot, S; Baubichon, D; Burckhart, MF; Lallement, G; Masqueliez, C; Veyret, J, 1997) |
| "[-]-Huperzine A ([-]-Hup A), is a naturally occurring potent reversible AChE inhibitor that penetrates the blood-brain barrier." | 1.39 | A combination of [+] and [-]-Huperzine A improves protection against soman toxicity compared to [+]-Huperzine A in guinea pigs. ( Doctor, BP; Nambiar, MP; Oguntayo, S; Wang, Y; Wei, Y, 2013) |
| " However, [-]-Huperzine A is toxic at higher doses due to potent AChE inhibition which limits the utilization of its neuroprotective properties." | 1.37 | [+]-Huperzine A protects against soman toxicity in guinea pigs. ( Doctor, BP; Jensen, N; Nambiar, MP; Oguntayo, S; Wang, Y; Wei, Y, 2011) |
| "EAAs sustain seizure activity and induce neuropathology due to over-stimulation of N-methyl-d-aspartate (NMDA) receptors." | 1.35 | [+]-Huperzine A treatment protects against N-methyl-D-aspartate-induced seizure/status epilepticus in rats. ( Coleman, BR; Doctor, BP; Gordon, RK; Nambiar, MP; Oguntayo, SA; Ratcliffe, RH; Shi, X, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 5 (45.45) | 29.6817 |
| 2010's | 5 (45.45) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gersner, R | 2 |
| Ekstein, D | 1 |
| Dhamne, SC | 1 |
| Schachter, SC | 2 |
| Rotenberg, A | 2 |
| Hamilton, LR | 1 |
| Myers, TM | 1 |
| Damar, U | 1 |
| Johnstone, JT | 1 |
| Schachter, S | 1 |
| Coleman, BR | 1 |
| Ratcliffe, RH | 1 |
| Oguntayo, SA | 1 |
| Shi, X | 1 |
| Doctor, BP | 3 |
| Gordon, RK | 1 |
| Nambiar, MP | 3 |
| Pibiri, F | 1 |
| Kozikowski, AP | 1 |
| Pinna, G | 1 |
| Auta, J | 1 |
| Kadriu, B | 1 |
| Costa, E | 1 |
| Guidotti, A | 1 |
| Wang, Y | 2 |
| Wei, Y | 2 |
| Oguntayo, S | 2 |
| Jensen, N | 1 |
| Lallement, G | 4 |
| Demoncheaux, JP | 1 |
| Foquin, A | 2 |
| Baubichon, D | 3 |
| Galonnier, M | 1 |
| Clarençon, D | 1 |
| Dorandeu, F | 2 |
| Veyret, J | 1 |
| Masqueliez, C | 2 |
| Aubriot, S | 1 |
| Burckhart, MF | 1 |
| Tonduli, LS | 1 |
| Testylier, G | 1 |
| Monmaur, P | 1 |
| Carpentier, P | 1 |
11 other studies available for huperzine a and Absence Seizure
| Article | Year |
|---|---|
Huperzine A prophylaxis against pentylenetetrazole-induced seizures in rats is associated with increased cortical inhibition.
Topics: Alkaloids; Animals; Anticonvulsants; Cerebral Cortex; Male; Neural Inhibition; Pentylenetetrazole; R | 2015 |
Time Course, Behavioral Safety, and Protective Efficacy of Centrally Active Reversible Acetylcholinesterase Inhibitors in Cynomolgus Macaques.
Topics: Alkaloids; Animals; Chemical Warfare Agents; Cholinesterase Inhibitors; Convulsants; Macaca fascicul | 2017 |
Huperzine A: A promising anticonvulsant, disease modifying, and memory enhancing treatment option in Alzheimer's disease.
Topics: Acetylcholinesterase; Alkaloids; Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetic | 2017 |
[+]-Huperzine A treatment protects against N-methyl-D-aspartate-induced seizure/status epilepticus in rats.
Topics: Acetylcholinesterase; Alkaloids; Animals; Body Temperature; Disease Models, Animal; Electroencephalo | 2008 |
The combination of huperzine A and imidazenil is an effective strategy to prevent diisopropyl fluorophosphate toxicity in mice.
Topics: Alkaloids; Animals; Benzodiazepines; Cognition Disorders; Drug Therapy, Combination; Imidazoles; Iso | 2008 |
[+]-Huperzine A protects against soman toxicity in guinea pigs.
Topics: Acetylcholinesterase; Alkaloids; Animals; Blood-Brain Barrier; Body Temperature; Chemical Warfare Ag | 2011 |
A combination of [+] and [-]-Huperzine A improves protection against soman toxicity compared to [+]-Huperzine A in guinea pigs.
Topics: Acetylcholinesterase; Alkaloids; Animals; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; | 2013 |
Subchronic administration of pyridostigmine or huperzine to primates: compared efficacy against soman toxicity.
Topics: Alkaloids; Animals; Chemical Warfare Agents; Cholinesterase Inhibitors; Macaca fascicularis; Male; P | 2002 |
Efficacy of huperzine in preventing soman-induced seizures, neuropathological changes and lethality.
Topics: Alkaloids; Animals; Brain; Cholinesterase Inhibitors; Electroencephalography; Guinea Pigs; Hippocamp | 1997 |
Effects of Huperzine used as pre-treatment against soman-induced seizures.
Topics: Acetylcholine; Acetylcholinesterase; Alkaloids; Animals; Brain; Cholinesterase Inhibitors; Electroen | 2001 |
Subchronic administration of various pretreatments of nerve agent poisoning. II. Compared efficacy against soman toxicity.
Topics: Alkaloids; Animals; Cholinesterase Inhibitors; Electroencephalography; Guinea Pigs; Male; Neuroprote | 2001 |