International journal of molecular sciences, 2023, May-06, Volume: 24, Issue:9
What triggers type 1 diabetes mellitus (T1DM)? One common assumption is that triggers are individual microbes that mimic autoantibody targets such as insulin (INS). However, most microbes highly associated with T1DM pathogenesis, such as coxsackieviruses (COX), lack INS mimicry and have failed to induce T1DM in animal models. Using proteomic similarity search techniques, we found that COX actually mimicked the INS receptor (INSR). Topics: Antibodies, Viral; Autoantibodies; Clostridium; Diabetes Mellitus, Type 1; Enterovirus; Enterovirus Infections; Humans; Insulin; Insulin, Regular, Human; Peptides; Proteomics | 2023 |