humulene and Perceptual-Disorders

Topics: Animals; Arousal; Cannabis; Cricetinae; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Emotions; Half-Life; Haplorhini; Humans; Mice; Perceptual Disorders; Phytotherapy; Psychoses, Substance-Induced; Rabbits; Substance-Related Disorders; Swine

Topics: Animals; Cannabis; Catecholamines; Cognition Disorders; Humans; Lysergic Acid Diethylamide; Perceptual Disorders; Phytotherapy; Serotonin Antagonists; Substance-Related Disorders

Access to cannabis and cannabinoid products is increasing worldwide for recreational and medicinal use. Two primary compounds within cannabis plant matter, Δ

Topics: Adolescent; Adult; Blood Pressure; Cannabidiol; Cannabinoid Receptor Modulators; Cannabis; Dissociative Disorders; Dronabinol; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Female; Heart Rate; Humans; Male; Middle Aged; Perceptual Disorders; Self Report; Young Adult

Moreau de Tours's classical studies about haschisch had pointed out to a rich symptomatology: visual and auditive hallucinations preceded by the "primordial effect": "the dissociation of ideas". This delirious state was assimilated to dream. Modern studies, conducted with Delta-9-THC, in healthy voluntaries, again suggest the comparison or even the identity of the modifications caused by cannabis with sleep and dream. 10 mg of Delta-9-THC was absorbed in sesame oil by the voluntaries, and all of them presented disturbances of their vigilance, changes of their mood, now with euphoris and now with dysphoria, and slight psycho-sensorial alterations. The voluntaries EEG showed important and specific individual reactivity. Three subjects presented an arousal tendency, three other a greater towards sleep. Slight morphological changes have appeared, such as desynchronised periods, rapid shifts between I A, I B, II stages of sleep or an hypovariable I B stage of sedation with period of occular movements resembling to REM-stage.

Topics: Adult; Affect; Attention; Cannabis; Clinical Trials as Topic; Cognition Disorders; Confusion; Dreams; Dronabinol; Electroencephalography; Euphoria; Female; Hallucinations; Humans; Intelligence; Male; Middle Aged; Perceptual Disorders; Personality Disorders; Substance-Related Disorders

Topics: Cannabis; Dronabinol; Humans; Perceptual Disorders; Phytotherapy; Placebos; Psychophysiologic Disorders; Psychoses, Substance-Induced; Substance-Related Disorders; United States

Cannabis is a psychotomimetic agent that induces impairment of sensory perception. We present detailed clinical and electrophysiological data of patients with hallucinogen persisting perception disorder (HPPD) after marijuana consumption.. A HPPD patient and four heavy cannabis smokers with no visual disturbances (controls) underwent complete ophthalmological examination including psychophysical tests (visual acuity, color vision, visual field, and dark adaptation) and detailed electrophysiological examinations, including extended Ganzfeld ERG, multifocal ERG, and electrooculography (EOG). Furthermore, electrically evoked phosphene thresholds (EPTs) were measured to further evaluate retinal function.. Ophthalmological and most electrophysiological examinations were within normal limits for the HPPD patient and for all control subjects. Interestingly, EOG results of the HPPD patient showed a slightly reduced fast oscillation ratio, diminished standing potentials of the slow oscillations, and a light peak within normal range resulting in higher Arden ratios. The EPTs of the patient were reduced, in particular for pulses with long durations (50 ms) causing visual sensations even at lowest possible currents of the neurostimulator. The control subjects did not reveal such alterations.. Our findings suggest a direct effect of cannabinoids on the retina and retinal pigment epithelium function, which may be involved in disturbances of the visual function experienced after drug consumption. The observations presented here may contribute to the elucidation of the detailed mechanism. Furthermore, EOG and EPT measurements may be useful tools to demonstrate long-term retinal alterations in cannabis-induced HPPD in patients.

Topics: Adult; Cannabis; Dark Adaptation; Electroretinography; Female; Humans; Male; Marijuana Abuse; Middle Aged; Perceptual Disorders; Retina; Retinal Pigment Epithelium; Vision Disorders; Visual Acuity; Visual Fields; Young Adult

Fifty persons who had all been heavy cannabis users for a long time were given psychological tests measuring psychomotor, perceptual and other variables. Half of these persons were "Charas" smokers, half "Bhang" drinkers. The duration of cannabis use was 4--10 years, with an average daily dose of 150 mg tetrahydrocannabinol. A matched control group of twenty-five persons were given the same tests. Compared with this group, the cannabis users were found to react more slowly, to be poorer in concentration and time estimation, to have higher neuroticism and greater perceptuo-motor disturbance. The higher neuroticism and greater perceptuo-motor disturbance. The Charas smokers were the poorest performers and also showed poor memory, lowered psychomotor activity, and poor size estimation.

Topics: Adolescent; Adult; Attention; Cannabis; Dronabinol; Humans; India; Middle Aged; Motor Skills; Neurotic Disorders; Perceptual Disorders; Psychological Tests; Reaction Time; Substance-Related Disorders; Time Perception

Topics: Alcoholic Intoxication; Amphetamine; Barbiturates; Brain; Cannabis; Cocaine; Emotions; Female; Hallucinations; Heroin Dependence; Humans; Libido; Male; Memory Disorders; Perceptual Disorders; Phytotherapy; Psychophysiology; Religion; Sexual Behavior; Sexual Dysfunction, Physiological; Substance-Related Disorders

Topics: Adolescent; Adult; Cannabis; Chlorpromazine; Consciousness; Drug Tolerance; Electroconvulsive Therapy; Hallucinations; Humans; Male; Memory; Perceptual Disorders; Psychoses, Substance-Induced; Social Behavior Disorders; Substance-Related Disorders; Thinking

Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Attitude; Cannabis; Crisis Intervention; Fear; Female; Health Education; Humans; Lysergic Acid Diethylamide; Male; Parents; Perceptual Disorders; Psychoses, Substance-Induced; Substance-Related Disorders

Topics: Cannabis; Dose-Response Relationship, Drug; Dronabinol; Heart Rate; Humans; Perceptual Disorders; Psychoses, Substance-Induced; Stimulation, Chemical; Substance-Related Disorders; Time Factors

Topics: Adolescent; Adult; Amphetamine; Barbiturates; Cannabis; Cocaine; Cognition Disorders; Factor Analysis, Statistical; Hallucinogens; Humans; Male; Morphinans; Perceptual Disorders; Psychological Tests; Socioeconomic Factors; Substance Withdrawal Syndrome; Substance-Related Disorders

Topics: Adolescent; Cannabis; Child Development; Euphoria; Humans; Legislation, Drug; Memory Disorders; Perceptual Disorders; Substance-Related Disorders

Topics: Adolescent; Adult; Cannabis; Female; Hallucinogens; Humans; Lysergic Acid Diethylamide; Male; Perceptual Disorders; Psychopathology; Psychoses, Substance-Induced; Substance-Related Disorders

Topics: Adolescent; Adult; Affective Symptoms; Cannabis; Drug and Narcotic Control; Hallucinogens; Humans; Juvenile Delinquency; Mescaline; Perceptual Disorders; Psilocybin; Social Control, Formal; Social Control, Informal; Substance-Related Disorders; Suicide; Switzerland