humulene and Obsessive-Compulsive-Disorder

There are overlapping biological origins and behaviors associated with obsessive-compulsive symptoms (OCS) and cannabis use. There is also evidence that OCS and cannabis use are associated over time. Thus, we investigated polygenic predisposition for OCS as predictive of OCS and cannabis use from age 17 to 19. We hypothesized that greater genetic risk for OCS would predict both OCS and cannabis use.. The current study used participants from the Project Alliance 1 study, a US-based sample, for whom genomic, OCS, and cannabis use data were available (n = 547). Polygenic risk scores (PRS) were formed via a meta-genome-wide association study on OCS and examined as a predictor of OCS and cannabis use at age 17 and 19. The sample was diverse (52.4% male; 45% European American, 30% African American, 14% multiracial, 5% Hispanic/Latino, 4% Asian American, and 2% other groups). Sensitivity analysis was performed by gender for European American and African American subsamples.. Across the whole sample, the greater polygenic risk for OCS was negatively associated with cannabis use at age 17 and positively associated with OCS at 19. Cannabis use at age 17 was positively associated with OCS at age 19. The association between polygenic risk for OCS and cannabis use at age 17 was replicated in European American males, whereas the association between cannabis use at age 17 and OCS at age 19 was replicated in African American males.. Cannabis use may exacerbate OCS through adolescence, and genetic predisposition for OCS may be associated with lower cannabis use in efforts to avoid exacerbation of OCS.

Topics: Adolescent; Adult; Cannabis; Comorbidity; Compulsive Behavior; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Male; Obsessive-Compulsive Disorder; Young Adult

Little is known about the the acute effects of cannabis on symptoms of OCD in humans. Therefore, this study sought to: 1) examine whether symptoms of OCD are significantly reduced after inhaling cannabis, 2) examine predictors (gender, dose, cannabis constituents, time) of these symptom changes and 3) explore potential long-term consequences of repeatedly using cannabis to self-medicate for OCD symptoms, including changes in dose and baseline symptom severity over time.. Data were analyzed from the app Strainprint® which provides medical cannabis patients a means of tracking changes in symptoms as a function of different doses and strains of cannabis across time. Specifically, data were analyzed from 87 individuals self-identifying with OCD who tracked the severity of their intrusions, compulsions, and/or anxiety immediately before and after 1,810 cannabis use sessions spanning a period of 31 months.. Patients reported a 60% reduction in compulsions, a 49% reduction in intrusions, and a 52% reduction in anxiety from before to after inhaling cannabis. Higher concentrations of CBD and higher doses predicted larger reductions in compulsions. The number of cannabis use sessions across time predicted changes in intrusions, such that later cannabis use sessions were associated with smaller reductions in intrusions. Baseline symptom severity and dose remained fairly constant over time.. The sample was self-selected, self-identified as having OCD, and there was no placebo control group.. Inhaled cannabis appears to have short-term beneficial effects on symptoms of OCD. However, tolerance to the effects on intrusions may develop over time.

Topics: Anxiety; Cannabis; Compulsive Behavior; Hallucinogens; Humans; Obsessive-Compulsive Disorder

The purpose of the present investigation was to examine the unique explanatory role of cannabis use motives above the effects of each other, for the relationship between obsessive-compulsive symptomatology and different aspects of cannabis misuse among young adults. The transitional years of young adulthood are characterized by new opportunities for experimentation as well as novel external stressors. Collectively, this makes this developmental epoch a sensitive time for manifestations of cannabis misuse.

Topics: Adaptation, Psychological; Adult; Anxiety; Cannabis; Humans; Motivation; Obsessive-Compulsive Disorder; Young Adult

Topics: Analgesics; Cannabis; Hallucinogens; Humans; Obsessive-Compulsive Disorder

Topics: Cannabis; Hallucinogens; Humans; Marijuana Use; Obsessive-Compulsive Disorder

Topics: Adolescent; Adult; Affective Symptoms; Age Factors; Aged; Anxiety Disorders; Cannabis; Child; Child Behavior Disorders; Child, Preschool; Egypt; Enuresis; Epilepsy; Family Characteristics; Female; Humans; Hypochondriasis; Hysteria; Infant; Male; Mental Disorders; Middle Aged; Obsessive-Compulsive Disorder; Occupations; Personality Disorders; Schizophrenia; Sex Factors; Social Class; Stuttering; Substance-Related Disorders