humulene and Hyperemesis-Gravidarum

To help obstetric care providers, including family physicians, nurse practitioners, midwives, and obstetricians, educate patients on the risks of cannabis use in pregnancy and postpartum and its relationship to nausea and vomiting in pregnancy.. The Ovid MEDLINE database was searched using the MeSH terms. In utero exposure to cannabis has been associated with long-term neurodevelopmental outcomes that persist into young adulthood. Cannabis should not be used to treat nausea and vomiting in pregnancy and its chronic use might lead to the development of cannabinoid hyperemesis syndrome.. There is no known safe level of cannabis use during pregnancy or lactation. Pregnant women should be counseled regarding the risks of in utero exposure and encouraged to abstain from use in pregnancy and while breastfeeding.

Topics: Cannabis; Child; Child, Preschool; Dronabinol; Female; Humans; Hyperemesis Gravidarum; Infant; Infant, Newborn; Marijuana Use; Neurodevelopmental Disorders; Postpartum Period; Pregnancy; Prenatal Exposure Delayed Effects; Substance-Related Disorders; Young Adult

To evaluate the risk of QT prolongation in patients treated for Cannabis Hyperemesis Syndrome (CHS) in the emergency department.. This was a retrospective comprehensive chart review of patients in the University of Colorado Health Emergency Department. Charts were identified by ICD9/10 codes from January 1, 2012 to December 31, 2014 for cannabis use and data were manually abstracted. We performed chi-square and odds ratios, stratified by drug, to determine differences in medication induced QTc prolongation and performed logistic regression to predict prolongation greater than 500 ms. We captured adverse events from medications as a secondary outcome.. We found 282 cases of CHS during the study period. There were no significant differences between the median post-medication QTc value stratified by drug when all medications were analyzed simultaneously. A multiple logistic regression model showed that only a potassium below 3.0 mmol/L predicted QT prolongation greater than 500 msec.. Anti-emetics used to treat CHS did not result in significant QTC prolongation in this cohort.

Topics: Antiemetics; Cannabinoid Receptor Agonists; Cannabis; Electrocardiography; Female; Hallucinogens; Humans; Hyperemesis Gravidarum; Long QT Syndrome; Pregnancy; Retrospective Studies; Risk Factors

Topics: Antiemetics; Cannabis; Female; Haloperidol; Humans; Hyperemesis Gravidarum; Ondansetron; Pregnancy; Vomiting

Topics: Cannabinoids; Cannabis; Female; Humans; Hyperemesis Gravidarum; Pregnancy; Vomiting