humulene and Hepatitis

Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the Western world, and it is closely associated to obesity, type 2 diabetes mellitus, and dyslipidemia. Medicinal cannabis and some neutral cannabinoids have been suggested as a potential therapy for liver diseases.. Δ. The antifibrotic activity of Δ. TGFβ-induced profibrotic gene expression was analyzed by luciferase and qPCR assays. Liver fibrosis and inflammation were assessed by immunochemistry and qPCR. Blood glucose, insulin, leptin and triglyceride levels were measured in HFD mice.

Topics: Animals; Cannabis; Carbon Tetrachloride; Diet, High-Fat; Dronabinol; Gene Expression Regulation; Hepatitis; Liver Cirrhosis; Male; Mice; Mice, Inbred C57BL; NIH 3T3 Cells; Non-alcoholic Fatty Liver Disease; Obesity

Embryonal cell carcinoma of the testis was seen in 2 homosexuals with peripheral lymphadenopathy of the head and neck, and abnormal cellular immunity measured by reduced T helper cells and increased T suppressor cells. One patient had no history of venereal disease but had taken marijuana, nitrites and methyl-dextroamphetamines regularly. The other patient had a history of syphilis, gonorrhea, hepatitis and venereal warts but rarely used inhalant recreational drugs. Both patients had smoked cigarettes. Neither patient had any known risk factors that predisposed to testicular cancer. Biopsy of a supraclavicular lymph node in 1 patient showed histological features of reactive follicular hyperplasia similar to those described previously in the acquired immune deficiency syndrome. These cases of testicular cancer increase the spectrum of rare cancers developing in young male homosexuals with acquired cellular immune abnormalities.

Topics: Acquired Immunodeficiency Syndrome; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cannabis; Cisplatin; Gonorrhea; Hepatitis; Homosexuality; Humans; Immunity, Cellular; Male; Nitrites; Substance-Related Disorders; Syphilis; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory; Teratoma; Testicular Neoplasms; Vincristine

Topics: Adult; Amphetamine; Barbiturates; Biopsy; Cannabis; Chemical and Drug Induced Liver Injury; Granuloma; Hepatitis; Hepatitis B Antigens; Heroin Dependence; Humans; Inflammation; Liver Diseases; Liver Function Tests; Male; Pharmaceutical Vehicles; Substance-Related Disorders; Talc

Topics: Adolescent; Adult; Age Factors; Aged; Alcohol Drinking; Amphetamine; Barbiturates; Black or African American; Cannabis; Cocaine; Crime; Family Characteristics; Female; Florida; Health Surveys; Hepatitis; Heroin; Humans; Lysergic Acid Diethylamide; Male; Middle Aged; Prisons; Sex Factors; Sexually Transmitted Diseases; Socioeconomic Factors; Substance-Related Disorders

Topics: Adolescent; Adult; Age Factors; Amphetamine; Barbiturates; Cannabis; Child; Cocaine; Hallucinogens; Hepatitis; Humans; Lysergic Acid Diethylamide; Mescaline; Morphine Dependence; Substance-Related Disorders; Surveys and Questionnaires

Topics: Adolescent; Adult; Biopsy; Cannabis; Chemical and Drug Induced Liver Injury; Female; Hepatitis; Humans; Injections, Intravenous; Jaundice; Liver; Lysergic Acid Diethylamide; Male; Mescaline; Morphine; Substance-Related Disorders

Topics: Adolescent; Adult; California; Cannabis; Child; Child, Preschool; Community Health Services; Female; Hepatitis; Humans; Infant; Infant, Newborn; Lysergic Acid Diethylamide; Male; Methamphetamine; Psychology, Social; Respiratory Tract Infections; Sexually Transmitted Diseases; Social Conditions; Substance-Related Disorders