humulene and Fractures--Bone

Cannabis has a rich history as a therapeutic tool with wide ranging applications. The efficacy of cannabidiol (CBD), the non-psychoactive component of cannabis, has been well demonstrated for pain management. Further, recent orthopedic studies have demonstrated positive effects of CBD on wound healing, inflammation, bone marrow density, and fracture healing. Despite the growing interest in CBD, there is a paucity of research on its impact on fracture risk and bone density in human clinical trials and the existing literature has significant limitations. As the rate of cannabis consumption increases, further research is essential to delineate the therapeutic qualities of CBD and its long-term effects on fracture healing and bone metabolism in order to optimize patient outcomes.

Topics: Cannabidiol; Cannabis; Fracture Healing; Fractures, Bone; Humans; Pain Management

An acute brain syndrome in a cannabis-dependent patient, who sustained multiple injuries, is described. Points of difference between this syndrome and delirium tremens are discussed. Recommendations are made regarding the treatment of this complication, which may follow multiple injuries or operative procedures.

Topics: Acute Disease; Adult; Alcohol Withdrawal Delirium; Cannabis; Diagnosis, Differential; Fractures, Bone; Humans; Male; Postoperative Complications; Substance Withdrawal Syndrome

Topics: Adolescent; Affective Symptoms; Cannabis; Child Health Services; Fractures, Bone; Gastrointestinal Diseases; Heroin Dependence; Humans; Juvenile Delinquency; Legislation as Topic; Male; Massachusetts; Medical History Taking; Physical Examination; Respiratory Tract Infections; Retrospective Studies; Skin Diseases; Sprains and Strains; Substance-Related Disorders; Wounds and Injuries