humulene and Erectile-Dysfunction

Substance abuse has become a worldwide health problem, leading to numerous consequences such as social problems among family members, abnormal behavior, adverse health effects, and psychological problems as well as economic consequences.. We sought to assess the relationship between substance abuse and male sexual health.. A search was carried out in the following databases: PubMed, MeSH (Medical Subject Headings), Science Direct, Scopus, Cochrane Library, EMBASE, CINAHL, Academic Search Complete, and the Egyptian Knowledge Bank. The following keywords were used to assess the outcomes for relevant associations: illicit drugs, addiction, substance abuse, sexual health, erectile dysfunction, ejaculatory disorders, impotence, orgasm disorders, and sexual performance.. The initial literature search identified a total of 148 articles in all searched databases. After removal of duplicate studies and application of inclusion/exclusion criteria, 75 reported studies were retained for review, including 38 case-control studies and 37 cross-sectional studies. These articles were classified into the following categories according to the type of abused substance addressed: cannabis/marihuana, 16 articles; opioids, 13 articles; heroin, 11 articles; cocaine, 5 articles; tramadol, 6 articles; ketamine, 2 articles; ecstasy, 4 articles; amphetamine, 2 articles; khat, 7 articles; androgen anabolic steroids, 2 articles; and polydrugs, 7 articles. Most of these recruited articles demonstrated a negative impact of the addressed substance on male sexual health, with variable levels.. Substance abuse has negative impacts on male sexual health that should be addressed. More studies conducted with proper methodological and statistical approaches, including logistic regression analysis, are needed to predict the effects of specific substances, considering the rapidly growing effects of non-substance-use disorders on male sexual health.

Topics: Amphetamine; Cannabis; Cross-Sectional Studies; Erectile Dysfunction; Humans; Male; Sexual Behavior; Substance-Related Disorders

Herbal medicine use, highly prevalent in the general population, is often a neglected component of the medical history. Herbs are presumed safe because they are "natural" self-care products. We call attention to the following issues: Panax ginseng, one of the most frequently used herbal medicines, has complex pharmacological activity, and can be associated with severe psychiatric symptoms. Physicians may be unfamiliar with herbal therapy risks, and the need for further education and systematic research is highlighted.. To describe two cases of new onset manic psychoses associated with high dose, chronic ginseng use, and review the relevant literature.. A 23-year-old man developed acute mania after one month of daily ginseng use and intermittent cannabis use. A 79-year-old man developed hypomania while using ginseng and yohimbine for erectile dysfunction, and had a recurrence of mania after stopping yohimbine but increasing his daily intake of ginseng.. Symptoms of mania fully remitted within days upon discontinuation of ginseng and supportive treatment. Available data prevent a clear determination of causation; however, ginseng-induced mania in the these and previous case reports is suggested by the following: patients had no prior psychiatric history, daily use of ginseng was temporally associated with mania onset, patients ingested much higher doses for a longer duration than recommended in Traditional Chinese Medicine (TCM), and withdrawal of ginseng led to rapid remission. Generally well tolerated, many physicians are unaware that ginseng may be associated with acute and significant psychiatric disturbances for certain at-risk individuals.

Topics: Adult; Aged; Bipolar Disorder; Cannabis; Dose-Response Relationship, Drug; Erectile Dysfunction; Humans; Male; Panax; Plant Extracts; Recurrence; Yohimbine

Cannabis (marijuana) is the most widely used illicit drug globally. Given the prevalence of nonprescription illicit drug abuse, there is a growing interest in the study of its potential effects on male sexual health. In this review, we discuss the effects of cannabis on male sexual health.. In this review, we discuss the effects of cannabis on male sexual health. METHODS AND MAIN OUTCOME MEASURE: Critical review of scientific literature examining the impact of cannabis use on male sexual health.. Studies examining the effects of cannabis use on male sexual function have been limited in both quality and quantity. Most results of these studies are conflicting and contradictory. While some did outline the beneficial effects of cannabis in enhancing erectile function, others did not. However, recent animal and in vitro studies have identified potential links between cannabis and sexual health. It appears that cannabis may actually have peripheral antagonizing effects on erectile function by stimulating specific receptors in the cavernous tissue.. Given the prevalence of cannabis use, and the potential relationships between use and the development of potentially hazardous effects on male sexual function, we encourage renewed use of research resources to determine in-depth mechanistic knowledge, and new clinically oriented studies examining the effect of cannabis on male sexual function.

Topics: Cannabis; Erectile Dysfunction; Humans; Illicit Drugs; Male; Marijuana Abuse; Prevalence; Risk Assessment; Sexual Behavior; Substance-Related Disorders

Topics: Antidepressive Agents; Antihypertensive Agents; Antipsychotic Agents; Cannabis; Ejaculation; Erectile Dysfunction; Ethanol; Female; Histamine H1 Antagonists; Humans; Hypnotics and Sedatives; Male; Parasympatholytics; Sexual Dysfunction, Physiological

Topics: Amyl Nitrite; Barbiturates; Caffeine; Cannabis; Erectile Dysfunction; Ethanol; Gonadal Steroid Hormones; Humans; Levodopa; Lithium; Male; Nicotine; Opium; Sexual Behavior; Thioridazine

Despite widespread usage, research on the relationship of marijuana use to disease is sorely lacking. We sought to test the relationship of LUTS/BPH treatment and endocannabinoid agonist usage, as well as alcohol usage and depression, with treatment for LUTS/BPH in our health system.. We queried our hospital system database of nearly three million patients in a marijuana-legalized region for data from the electronic medical record between January 2011 and October 2018. Men over the age of 45 on medical therapy for LUTS (selective alpha blockade and/or finasteride) were included. Exclusions were diagnosis of bladder or prostate malignancy and men with only one visit. Alcohol and marijuana (MJ) use were found from diagnosis code and/or social history text. Medical diagnoses were based on ICD-9/10 codes. Multiple logistic regression was used to control for confounders. We considered all men over the age of 45 who had any of these features: depression, obesity or metabolic syndrome (MetS), hypertension (HTN), erectile dysfunction (ED), hypogonadism, diabetes (DM) and calculated the odds ratio of also receiving medical therapy for LUTS. Univariable and multivariable analyses were employed, multiple logistic regression was used to control for confounders.. A total of 173,469 patients were identified meeting criteria with 20,548 (11.9%) on medical treatment for LUTS. After adjusting for confounding variables, MJ and depression remained associated with an increased risk of LUTS medication, within the context of verifying previously established relationships of ED, Obesity/MetS, DM, HTN and hypogonadism.. Men with depression and MJ usage were more likely to be treated for LUTS/BPH in our system. Better understanding of the causality of this relationship and potential interaction of LUTS/BPH with the endocannabinoid system is desirable.

Topics: Cannabis; Depression; Endocannabinoids; Erectile Dysfunction; Humans; Hypertension; Hypogonadism; Lower Urinary Tract Symptoms; Male; Obesity; Prostatic Hyperplasia

Topics: Analgesics; Cannabis; Erectile Dysfunction; Humans; Male

Topics: Antihypertensive Agents; Cannabis; Ejaculation; Endocrine Glands; Erectile Dysfunction; Ethanol; Humans; Male; Narcotics; Parasympatholytics; Penis; Prolactin

Topics: Animals; Automobile Driving; Brain; Cannabis; Chromosomes; Dronabinol; Erectile Dysfunction; Female; Haplorhini; Humans; Immunity; Lung; Male; Mice; Pregnancy; Substance-Related Disorders

Topics: Alcohol Drinking; Aphrodisiacs; Attitude; Cannabis; Erectile Dysfunction; Female; Humans; Interpersonal Relations; Male; Public Opinion; Sex Education; Sexual Behavior; Sexual Dysfunction, Physiological; Smoking; Substance-Related Disorders; Transsexualism; United States

Topics: Age Factors; Cannabis; Chromosome Aberrations; Drug and Narcotic Control; Erectile Dysfunction; Female; Humans; Immunity, Cellular; International Cooperation; Legislation, Drug; Male; Maternal-Fetal Exchange; Personality Disorders; Pregnancy; Public Opinion; Research Support as Topic; Substance-Related Disorders; United States

Topics: Animals; Cannabis; Erectile Dysfunction; Humans; Libido; Male; Spermatogenesis; Testosterone