humulene and Drug-Hypersensitivity

Topics: Cannabinoids; Cannabis; Carcinogens; Chemical Phenomena; Chemistry; Chronic Disease; Drug Contamination; Drug Hypersensitivity; Humans; Immunity, Cellular; Respiratory Tract Diseases

Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Cannabis; Crime; Drug Hypersensitivity; Epilepsy, Tonic-Clonic; Female; Humans; Male; Memory; Mental Disorders; Pregnancy; Psychoses, Substance-Induced; Social Behavior Disorders

Drug allergy has been a research topic within the allergy field for decades. However, many drug reactions presumed to be of allergic nature are not and originate from different mechanisms. Drug-induced reactions can affect numerous organ systems, present with various symptoms, and have more than 1 mechanism of action. In this rostrum article, we want to give an overview of the different allergic and nonallergic reactions that can be expected with the (illicit) use of cannabis, cocaine, opioids, and alcohol. In addition, this article focuses on the different methods available to diagnose allergy related to these 4 drug types and highlight the pitfalls of nonallergic reactions or allergy "mimickers" complicating the diagnosis of true drug allergy. Finally, the impact on current medical practices and future research in support of the allergist in diagnosis and treatment of these medical problems is addressed.

Topics: Analgesics, Opioid; Cannabis; Cocaine; Drug Hypersensitivity; Humans; Illicit Drugs; Substance-Related Disorders

Selection and culture in a Phytotron of plants of Cannabis sativa L. with high content of propyl-THC are obtained. Then it was possible to isolate a large quantity of propyl-THC by column chromatography. Spectroscopic analysis is done. Pharmacological tests are being run; first results revealed the allergenicity of this substance by comparison with the properties of tetrahydrocannabinol, the active principle of Cannabis.

Topics: Animals; Cannabis; Chemical Phenomena; Chemistry; Dronabinol; Drug Hypersensitivity; Guinea Pigs; Isomerism; Magnetic Resonance Spectroscopy; Mass Spectrometry

Topics: Adult; Cannabis; Conjunctivitis; Drug Hypersensitivity; Female; Humans; Rhinitis, Allergic, Seasonal

Topics: Adrenal Glands; Animals; Barbiturates; Behavior, Animal; Body Weight; Brain; Cannabis; Drinking Behavior; Drug Hypersensitivity; Extinction, Psychological; Female; Heart; Humans; Kidney; Organ Size; Pentylenetetrazole; Plant Extracts; Rats; Seizures; Substance Withdrawal Syndrome; Time Factors

Topics: Age Factors; Cannabis; Dronabinol; Drug Hypersensitivity; Drug Tolerance; Heart Rate; Humans; Injections, Intravenous; Male; Perception; Phytotherapy; Plasma Volume; Time Factors; Tritium

Topics: Adult; Cannabis; Dronabinol; Drug Hypersensitivity; Female; Humans; Immunization, Passive; Skin Tests; Smoking; Substance-Related Disorders

Topics: Adolescent; Adult; Alanine Transaminase; Aspartate Aminotransferases; Bronchitis; Cannabis; Chemical and Drug Induced Liver Injury; Colic; Drug Hypersensitivity; Female; Gingivitis; Humans; Laryngitis; Liver Diseases; Male; Migraine Disorders; Otitis; Pharyngitis; Respiratory Tract Diseases; Sinusitis; Stomatitis; Substance-Related Disorders; Vascular Diseases

Topics: Alcoholism; Caffeine; Cannabis; Central Nervous System; Cocaine; Drug Hypersensitivity; Hallucinogens; History, 16th Century; History, 18th Century; History, 19th Century; History, 20th Century; Humans; Lithium; Mercury Poisoning; Morphine Dependence; Penicillins; Pharmacology; Poisoning; Smoking; Substance-Related Disorders; Syphilis; Technology; Thalidomide; Triparanol