humulene and Dermatitis--Contact

The authors describe an unusual case of LTP allergy. A 35 years old patient presented repeated episodes of angiooedema after food intake and complained 10 years ago of contact urticaria and rhinoconjunctivitis when exposed to cannabis leaves and to marijuana smoke. The suspected responsible foods, such as wheat flour in bread, are known to contain LTR Oral syndrome occurred after ingestion of walnuts. Cutaneous tests confirmed immediate responses to several flours and nuts and also to cannabis leaf and flower. A few months later he had similar accidents following peach ingestion and drinking of beer and several wines which all induced positive skin tests. Serological investigations using ImmunoCAP and ISAC microarray confirmed IgE positivity for n Pru p3, r Cor a 8 and n Art v3. It was assumed that sensitization to LTP, the major allergen of cannabis, was responsible of the primary sensitization and induced further LTP food allergies.

Topics: Adult; Antigens, Plant; Bread; Cannabinoids; Cannabis; Carrier Proteins; Cross Reactions; Dermatitis, Contact; Flour; Food Hypersensitivity; Humans; Juglans; Male; Marijuana Smoking; Plant Proteins; Skin Tests

Topics: Adult; Allergens; Antigens, Plant; Binding Sites, Antibody; Cannabis; Carrier Proteins; Dermatitis, Contact; Humans; Immunoglobulin E; Male; Plant Proteins

A 26-year aged non-atopic criminological technician reacted to hemp (Cannabis sativa) and hashish with urticarial eruptions on hands and lower arms, rhinitis and conjunctivitis. Rubbing tests with pollenrich hashish were strongly positive. As hemp antigens were unavailable a hyposensitization therapy with hop (Humulus lupulus)--a plant belonging to the Cannabacea family--was begun.

Topics: Adult; Cannabis; Conjunctivitis; Dermatitis, Contact; Dermatitis, Occupational; Humans; Hypersensitivity, Immediate; Laboratories; Male; Pollen; Rhinitis; Urticaria