humulene and Coronary-Disease

Topics: Adult; Angina Pectoris; Blood Pressure; Cannabis; Cardiac Output; Clinical Trials as Topic; Coronary Disease; Echocardiography; Heart Rate; Hemodynamics; Humans; Male; Middle Aged; Placebos; Time Factors

Topics: Adult; Angina Pectoris; Cannabis; Coronary Disease; Diabetes Mellitus; Female; Humans; Male; Middle Aged; Nutrition Surveys

Topics: Cannabis; Cardiac Output; Coronary Disease; Dronabinol; Heart Rate; Myocardial Contraction

The purpose of this study was to determine the effect of smoking marihuana and of high-nicotine cigarettes on exercise-induced angina pectoris. Smoking 1 marihuana cigarette increased the resting product of systolic blood pressure times heart rate 54%, increased the venous carboxyhemoglobin level, and decreased the exercise time until angina 50% in 10 patients with angina pectoris. Smoking 1 high-nicotine cigarette increased the resting product of systolic blood pressure times heart rate 36%, increased the venous carboxyhemoglobin level, and decreased the exercise time until angina 23%. Smoking either marihuana or high-nicotine cigarettes decreases exercise performance until angina by increasing myocardial oxygen demand and by decreasing myocardial oxygen delivery. Smoking 1 marihuana cigarette decreased the exercise time until angina more than smoking 1 high-nicotine cigarette (p less than 0.001).

Topics: Angina Pectoris; Blood Pressure; Cannabis; Carboxyhemoglobin; Coronary Disease; Electrocardiography; Exercise Test; Heart Rate; Humans; Male; Middle Aged; Nicotine; Smoking