humulene and Brain-Damage--Chronic

Topics: Adolescent; Adult; Brain Damage, Chronic; Cannabinoids; Cannabis; Child; Chromosome Aberrations; Chromosome Disorders; Female; Growth Hormone; Humans; Immunity, Cellular; Male; Psychomotor Disorders; Research; Substance-Related Disorders; Testosterone; United States

Topics: Amphetamines; Animals; Brain; Brain Damage, Chronic; Cannabis; Catecholamines; DOM 2,5-Dimethoxy-4-Methylamphetamine; Dose-Response Relationship, Drug; Dronabinol; Hallucinogens; Haplorhini; Humans; Injections, Intravenous; Lysergic Acid Diethylamide; Mescaline; N,N-Dimethyltryptamine; Narcolepsy; Psilocybin; Rats; Seizures; Serotonin Antagonists; Substance-Related Disorders

Ten normal subjects who smoked marijuana daily for an average of 5 years and who denied other drug use were examined on a neuropsychological test battery. When compared with normal nonsmoking Ss, minimal differences were observed. It was concluded that long-term cannabis use does not cause a generalized decrement in adaptive abilities which might be related to cerebral impairments.

Topics: Adult; Auditory Perception; Brain Damage, Chronic; Cannabis; Cognition; Female; Humans; Intelligence; Male; Motor Skills; Perception; Psychological Tests; Speech; Substance-Related Disorders; Time Factors

Cannabis is not a harmless drug. The potential dangers of cannabis are briefly reviewed in this report. The above-mentioned observations on cannabis users should be kept in mind and carefully examined by all physicians. One could expect that as more potent cannabis preparations become available, some of the toxic manifestations which now seem rare might become more frequent. Some of the remarks about the dangers of cannabis may not be proved in future studies, and they may represent only our anxiety. However, prior to the elimination of these fears, no steps should be taken toward the legalizing of marijuana. At present there is no scientific evidence that cannabis is less harmful than either tobacco or alcohol. The opposite may be true. The analogy can be drawn between opium and cannabis. The permissive attitude toward the use of opium can easily lead to the use of morphine and other opiates. If we legalize the use of marijuana, we cannot prevent the use of more dangerous derivatives of cannabis; namely, hashish, cannabis oil and THC, itself. In my opinion, in the light of our present knowledge, legalizing of marijuana could be hazardous both for the individual and for society.

Topics: Animals; Brain Damage, Chronic; Cannabis; Cardiovascular Diseases; Chemical and Drug Induced Liver Injury; Cricetinae; Gastrointestinal Diseases; Humans; Liver; Rabbits; Rats; Respiratory Tract Diseases; Substance-Related Disorders

Topics: Brain; Brain Damage, Chronic; Cannabis; Dose-Response Relationship, Drug; Dronabinol; Humans; Motivation

Topics: Abnormalities, Drug-Induced; Accidents, Traffic; Animals; Brain Damage, Chronic; Cannabis; Carcinogens; Central Nervous System; Crime; Dronabinol; Drug and Narcotic Control; Drug Evaluation; Drug Evaluation, Preclinical; Humans; Legislation, Drug; Mutagens; Personality Disorders; Phytotherapy; Psychoses, Substance-Induced; Rabbits; Rats; Substance-Related Disorders; United Kingdom

Topics: Adolescent; Age Factors; Brain Damage, Chronic; Cannabis; Family; Female; Humans; Intelligence; Lysergic Acid Diethylamide; Male; Morphinans; Personality Disorders; Prognosis; Psychoses, Substance-Induced; Substance-Related Disorders; Time Factors

Topics: Brain Damage, Chronic; Cannabis; Humans; Male; Substance-Related Disorders; United Kingdom

Topics: Adult; Amphetamine; Brain Damage, Chronic; Cannabis; Communication; Female; Health Education; Humans; Legislation, Drug; Lysergic Acid Diethylamide; Male; Methamphetamine; Opium; Substance-Related Disorders; Suicide; United States