humulene and Alcohol-Related-Disorders

This study examined approaches to delivering brief interventions (BI) for risky substance use and sexual behaviors in school-based health centers (SBHCs).. 300 Adolescents (ages 14-18; 54 % female) with risky marijuana and/or alcohol use identified via CRAFFT screening (scores >1) were recruited from two SBHCs and randomized to computer-delivered BI (CBI) or nurse practitioner-delivered BI (NBI). Both BIs included motivational and didactic content targeting marijuana, alcohol, and risky sexual behaviors. Assessments at baseline, 3-month, and 6-month follow-up included past 30-day frequency of marijuana use, alcohol use, binge drinking, unprotected sex, and sex while intoxicated; marijuana and alcohol problems; and health-related quality-of-life (HRQoL). A focused cost-effectiveness analysis was conducted. An historical 'assessment-only' cohort (N=50) formed a supplementary quasi-experimental comparison group.. There were no significant differences between NBI and CBI on any outcomes considered (e.g., days of marijuana use; p=.26). From a cost-effectiveness perspective, CBI was 'dominant' for HRQoL and marijuana use. Participants' satisfaction with BI was significantly higher for NBI than CBI. Compared to the assessment-only cohort, participants who received a BI had lower frequency of marijuana (3-months: Incidence Rate Ratio [IRR] = .74 [.57, .97], p=.03), alcohol (3-months: IRR = .43 [.29, .64], p<.001; 6-months: IRR = .58 [.34, .98], p = .04), alcohol-specific problems (3-months: IRR = .63 [.45, .89], p=.008; 6-months: IRR = .63 [.41, .97], p = .04), and sex while intoxicated (6-months: IRR = .42 [.21, .83], p = .013).. CBI and NBI did not yield different risk behavior outcomes in this randomized trial. Supplementary quasi-experimental comparisons suggested potential superiority over assessment-only. Both NBI and CBI could be useful in SBHCs.

Topics: Adolescent; Alcohol Drinking; Alcohol-Related Disorders; Cannabis; Computers; Crisis Intervention; Female; Health Risk Behaviors; Humans; Male; Marijuana Smoking; Marijuana Use; Mass Screening; Nurse Practitioners; Risk-Taking; School Health Services; Schools; Sexual Behavior; Substance-Related Disorders

Experiences of racial discrimination among Black Americans are associated with numerous adverse behavioral health outcomes, including risk for substance use. Research has shown ethnic identity to be directly related to reduced substance use risk among Black Americans, as well as mitigate substance use risk as a consequence of exposure to racial discrimination. However, whether the specific facet of ethnic identity (affirmation and exploration), is related to the relationship between racial discrimination and problem substance use based on substance type is unclear. Thus, the current study examined 1) the association between ethnic identity (affirmation and exploration) and problem alcohol and cannabis use, and 2) whether ethnic identity affirmation or exploration moderates the association between racial discrimination and problem substance use among a sample of Black young adults.. Three-hundred and ninety Black young adults ages 18-24 (M = 20.6, 62 % female, 85 % monoracial) completed an online survey that included measures on past-year experiences of racial discrimination, ethnic identity affirmation and exploration, and problem alcohol and cannabis use. Utilizing multiple linear regression and the PROCESS macro, the study examined the promotive (direct) association between ethnic identity and problem substance use, and the protective (moderating) effect of ethnic identity on the relationship between racial discrimination and problem substance use.. After accounting for the demographic covariates of age, gender (male, female, and other), and race (monoracial and bi/multiracial), higher ethnic identity affirmation was significantly associated with lower problem alcohol, and higher ethnic identity exploration was significantly associated with lower problem alcohol and cannabis use. The study also observed a moderating effect of ethnic identity affirmation and exploration on the relationship between racial discrimination and problem alcohol use. Specifically, the association between racial discrimination and problem alcohol use weakened at higher levels of ethnic identity affirmation and exploration. Neither ethnic identity affirmation nor exploration significantly moderated the relationship between racial discrimination and problem cannabis use.. Findings suggest that ethnic identity is associated with problem alcohol use and may also reduce the strength of the association between racial discrimination and problem alcohol use, although these findings need to be confirmed with longitudinal study designs. If supported, interventions focused on strengthening one's ethnic identity affirmation and exploration may offer a potential target for interventions addressing alcohol misuse among Black young adults. However, more research should seek to understand promotive and protective factors for problem cannabis use among Black young adults.

Topics: Alcohol-Related Disorders; Alcoholism; Cannabis; Ethnicity; Female; Humans; Longitudinal Studies; Male; Social Identification; Substance-Related Disorders; Young Adult

There is substantial evidence linking anxiety sensitivity and distress intolerance to depressive symptoms, and further evidence linking depressive symptoms to alcohol and cannabis use. However, the prospective indirect associations of anxiety sensitivity and distress intolerance with alcohol and cannabis use through depressive symptoms remain uncertain. Thus, the current study examined whether depressive symptoms mediated the associations between anxiety sensitivity and distress intolerance with alcohol and cannabis use frequency, quantity, and problems in a longitudinal sample of veterans.. Participants (. Baseline anxiety sensitivity was positively associated with 12-month alcohol problems. Baseline distress intolerance was positively associated with 12-month cannabis use frequency and quantity. Baseline anxiety sensitivity and distress intolerance significantly predicted increased alcohol problems and cannabis use frequency at 12 months through depressive symptoms at 6 months. There were no significant indirect effects of anxiety sensitivity and distress intolerance on alcohol use frequency or quantity, cannabis use quantity, or cannabis problems.. Anxiety sensitivity and distress intolerance share a common pathway to alcohol problems and cannabis use frequency through depressive symptoms. Interventions focused on modulating negative affectivity may reduce cannabis use frequency and alcohol problems.

Topics: Alcohol-Related Disorders; Anxiety; Cannabis; Depression; Female; Humans; Male; Veterans

Impulsivity is an established etiological risk factor for alcohol- and cannabis-related outcomes. However, limited work has focused on longitudinal associations between multiple trait impulsivity facets and indices of alcohol and cannabis use among military veterans-a contextually distinct population that evidence unique impulsive personality traits and substance use patterns.. A structural equation model (SEM) examined longitudinal associations between five UPPS-P impulsivity facets measured at baseline and six indices of alcohol and cannabis use (i.e., frequency, quantity, and problems) measured at 1-year follow-up among 361 returning Operation Enduring Freedom, Operation Iraqi Freedom, and Operation New Dawn (OEF/OIF/OND) veterans.. Findings indicated baseline sensation seeking was significantly positively associated with 1-year alcohol use frequency (β = .18); baseline negative urgency was positively associated with alcohol use problems (β = .31); and baseline lack of perseverance (β = .25) and sensation seeking (β = .21) were positively associated with 1-year cannabis use problems. None of the baseline impulsivity facets were associated with 1-year alcohol use quantity, cannabis use frequency, or cannabis use quantity.. Results provide preliminary support that impulsivity may play a unique role in understanding alcohol- and cannabis-related problems over time among veterans. Further, results suggest that specific impulsivity facets are prospectively associated with cannabis problems (i.e., lack of perseverance and sensation seeking) and alcohol problems (i.e., negative urgency). Findings reinforce the importance of differentially evaluating impulsivity-substance use associations within contextually distinct populations (e.g., adolescent, veteran), and highlight potentially meaningful intervention targets among veterans. However, replication is needed with stronger temporal controls and more diverse veteran subsamples. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Topics: Adolescent; Alcohol Drinking; Alcohol-Related Disorders; Cannabis; Humans; Impulsive Behavior; Substance-Related Disorders; Veterans

Topics: Alcohol Drinking; Alcohol-Related Disorders; Canada; Cannabis; Ethanol; Female; Humans; Male; Reproducibility of Results; Young Adult

The authors sought to estimate the prevalence of past-12-month and lifetime cannabis use and cannabis use disorder among U.S. veterans; to describe demographic, substance use disorder, and psychiatric disorder correlates of nonmedical cannabis use and cannabis use disorder; and to explore differences in cannabis use and cannabis use disorder prevalence among veterans in states with and without medical marijuana laws.. Participants were 3,119 respondents in the 2012-2013 National Epidemiologic Survey on Alcohol and Related Conditions-III (NESARC-III) who identified as U.S. veterans. Weighted prevalences were calculated. Logistic regression analyses tested associations of nonmedical cannabis use and cannabis use disorder with demographic and clinical correlates and examined whether prevalence differed by state legalization status.. The prevalences of any past-12-month cannabis use and cannabis use disorder were 7.3% and 1.8%, respectively. Lifetime prevalences were 32.5% and 5.7%, respectively. Past-12-month and lifetime cannabis use disorder prevalence estimates among nonmedical cannabis users were 24.4% and 17.4%, respectively. Sociodemographic correlates of nonmedical cannabis use and use disorder included younger age, male gender, being unmarried, lower income, and residing in a state with medical marijuana laws. Nonmedical cannabis use and use disorder were associated with most psychiatric and substance use disorders examined.. Among veterans, the odds of nonmedical cannabis use and use disorder were elevated among vulnerable subgroups, including those with lower income or psychiatric disorders and among survey participants residing in states with medical marijuana laws. The study findings highlight the need for clinical attention (e.g., screening, assessment) and ongoing monitoring among veterans in the context of increasing legalization of cannabis.

Topics: Alcohol-Related Disorders; Cannabis; Ethanol; Hallucinogens; Humans; Male; Marijuana Abuse; Medical Marijuana; Prevalence; Substance-Related Disorders; United States; Veterans

This study measured emergency department (ED) use and hospitalization for medical reasons among patients with substance-related disorders (SRD), comparing four subgroups: cannabis-related disorders, drug-related disorders other than cannabis, alcohol-related disorders and polysubstance-related disorders, controlling for various clinical, sociodemographic and service use variables.. Clinical administrative data for a cohort of 22,484 patients registered in Quebec (Canada) addiction treatment centers in 2012-13 were extracted for the years 2009-10 to 2015-16. Using negative binomial models, risks of frequent ED use and hospitalization were calculated for a 12-month period (2015-16).. Patients with polysubstance-related disorders used ED more frequently than other groups with SRD. They were hospitalized more frequently than patients with cannabis or other drug-related disorders, but less frequently than those with alcohol-related disorders. Patients with alcohol-related disorders used ED more frequently than those with cannabis-related disorders and underwent more hospitalizations than both patients with cannabis-related and other drug-related disorders. Co-occurring SRD-mental disorders or SRD-chronic physical illnesses, more years with SRD, being women, living in rural territories, more frequent consultations with usual general practitioner or outpatient psychiatrist, and receiving more interventions in community healthcare centers increased frequency of ED use and hospitalization, whereas both adverse outcomes decreased with high continuity of physician care. Behavioral addiction, age less than 45 years, living in more materially deprived areas, and receiving 1-3 interventions in addiction treatment centers increased risk of frequent ED use, whereas living in semi-urban areas decreased ED use. Patients 25-44 years old receiving 4+ interventions in addiction treatment centers experienced less frequent hospitalization.. Findings showed higher risk of ED use among patients with polysubstance-related disorders, and higher hospitalization risk among patients with alcohol-related disorders, compared with patients affected by cannabis and other drug-related disorders. However, other variables contributed substantially more to the frequency of ED use and hospitalization, particularly clinical variables regarding complexity and severity of health conditions, followed by service use variables. Another important finding was that high continuity of physician care helped decrease the use of acute care services. Strategies like integrated care and outreach interventions may enhance SRD services.

Topics: Adult; Alcohol-Related Disorders; Cannabis; Emergency Service, Hospital; Female; Hospitalization; Humans; Male; Marijuana Abuse; Middle Aged; Referral and Consultation; Substance-Related Disorders

Topics: Adolescent; Aggression; Alcohol-Related Disorders; Alcoholism; Cannabis; Humans; Marijuana Abuse

Previous research has reported that sleep problems longitudinally predict both onset of cannabis use and cannabis-related problems. However, the mediators of this relationship remain unclear. The present study examined (a) the concurrent relationship between insomnia symptoms and hazardous cannabis use and (b) examined whether use of protective behavioral strategies (PBS) for cannabis mediated this relationship among college student cannabis users. Participants were 984 (69.9% female) college students who reported consuming cannabis at least once in the past month and completed measures of insomnia, cannabis PBS, and cannabis misuse. Data were analyzed by structural equation modeling for binary and count outcomes. The significance of the mediator was evaluated using bias-corrected bootstrap confidence intervals. Insomnia symptoms were associated with an increase in the odds of hazardous cannabis use and possible cannabis use disorder. Cannabis PBS significantly mediated the relationship between insomnia symptoms and hazardous cannabis use, cannabis use disorder symptoms, and cannabis-related problems. Specifically, higher reports of insomnia symptoms were associated with lower use of cannabis PBS; which in turn was associated with an increase in the odds of hazardous cannabis use and possible cannabis use disorder, as well as a higher report of cannabis-related problems. Implications of these findings on the prevention of cannabis use problems among college students in the United States were discussed. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

Topics: Adult; Alcohol-Related Disorders; Cannabis; Female; Humans; Male; Marijuana Smoking; Sleep Initiation and Maintenance Disorders; Students; Substance-Related Disorders; United States; Universities; Young Adult

There has been considerable interest in the extent to which substance use and unemployment may be related, particularly the causal pathways that may be involved in these associations. It has been argued that these associations may reflect social causation, in which unemployment influences substance use, or that they may reflect social selection, in which substance use increases the risk of becoming and remaining unemployed. The present study sought to test these competing explanations.. Data from the Christchurch Health and Development Study, featuring a longitudinal birth cohort, were used to model the associations between unemployment and both cannabis and alcohol. Data on patterns of unemployment, involvement with cannabis, and symptoms of alcohol use disorder were examined from ages 18-35 years. The associations between unemployment and both cannabis dependence and alcohol use disorder (AUD) were modelled using conditional fixed-effects regression models, augmented by time-dynamic covariate factors.. The analyses showed evidence of possible reciprocal causal processes in the association between unemployment and cannabis dependence, in which unemployment of at least three months' duration significantly (p < 0.0001) increased the risk of cannabis dependence, and cannabis dependence significantly (p < 0.0001) increased the risk of being unemployed. Similar evidence was found for the associations between unemployment and AUD, although these associations were smaller in magnitude.. The present findings support both social causation and social selection arguments, by indicating that unemployment plays a causal role in substance misuse, and that it is also likely that a reverse causal process whereby substance misuse increases the risk of unemployment.

Topics: Adolescent; Adult; Alcohol Drinking; Alcohol-Related Disorders; Cannabis; Causality; Cohort Studies; Female; Humans; Longitudinal Studies; Male; Peer Group; Risk Factors; Substance-Related Disorders; Unemployment; Young Adult

Published data suggest that cannabis use is associated with several negative consequences for individuals with bipolar disorder (BD), including new manic episode onset, psychosis, and functional disability. Yet much less is known about cannabis use disorders (CUDs) in this population, especially in more acutely symptomatic groups.. To evaluate correlates of CUD comorbidity in BD, a retrospective chart review was conducted for 230 adult patients with bipolar I disorder (BDI) who were admitted to a university-affiliated private psychiatric hospital. Using a computer algorithm, a hospital administrator extracted relevant demographic and clinical data from the electronic medical record for analysis.. Thirty-six (16%) had a comorbid CUD. CUD comorbidity was significantly associated with younger age, manic/mixed episode polarity, presence of psychotic features, and comorbid nicotine dependence, alcohol use disorder (AUD), and other substance use disorders, but was associated with decreased likelihood of anxiety disorder comorbidity. With the exception of manic/mixed polarity and AUD comorbidity, results from multivariate analyses controlling for the presence of other SUDs were consistent with univariate findings.. Patients with BD and comorbid CUDs appear to be a complex population with need for enhanced clinical monitoring. Given increasing public acceptance of cannabis use, and the limited availability of evidenced-based interventions targeted toward CUDs in BD, psychoeducation and other treatment development efforts appear to be warranted.

Topics: Adult; Alcohol-Related Disorders; Bipolar Disorder; Cannabis; Comorbidity; Female; Humans; Inpatients; Male; Marijuana Smoking; Medical Records; Middle Aged; Psychotic Disorders; Retrospective Studies; Substance-Related Disorders

The study assesses the degree to which individuals in different trajectories of marijuana use are similar or different in terms of unconventional behavior, sensation seeking, emotional dysregulation, nicotine dependence, alcohol dependence/abuse, children living at home, and spouse/partner marijuana use at age 43.. This study used a longitudinal design. The sample participants (N = 548) were first studied at mean age 14 and last studied at mean age 43.. Six trajectories of marijuana use were identified: chronic/heavy users (3.6 %), increasing users (5.1 %), chronic/occasional users (20 %), decreasers (14.3 %), quitters (22.5 %), and nonusers/experimenters (34.5 %). With three exceptions, as compared with being a nonuser/experimenter, a higher probability of belonging to the chronic/heavy, the increasing, or the chronic/occasional user trajectory group was significantly associated with a greater likelihood of unconventional behavior, sensation seeking, emotional dysregulation, nicotine dependence, alcohol dependence/abuse, not having children who lived at home, and having a spouse/partner who used marijuana at early midlife. In addition, compared with being a quitter, a higher probability of belonging to the chronic/heavy user trajectory group was significantly associated with a higher likelihood of unconventional behavior, sensation seeking, emotional dysregulation, alcohol dependence/abuse, and spouse/partner marijuana use. Implications for intervention are presented.. Trajectories of marijuana use, especially chronic/heavy use, increasing use, and chronic/occasional use, are associated with unconventional behavior, sensation seeking, emotional dysregulation, nicotine dependence, alcohol dependence/abuse, having children who lived at home, and spouse/partner marijuana use at age 43. The importance of the findings for prevention and treatment programs are discussed.

Topics: Adolescent; Adult; Alcohol-Related Disorders; Cannabis; Female; Human Development; Humans; Longitudinal Studies; Male; Marijuana Abuse; Marijuana Smoking; New York; Tobacco Use Disorder; Young Adult

The association between cannabis use and mood disorders is well documented, yet evidence regarding causality is conflicting. This study explored the association between cannabis use, major depressive disorder (MDD) and bipolar disorder (BPD) in a 3-year prospective study.. Data was drawn from waves 1 and 2 of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). MDD and BPD were controlled at baseline and defined as meeting full criteria in the 12 months prior to the follow-up. Initiation of cannabis use was defined as any cannabis used by former lifetime abstainers in the time period between baseline and follow-up.. Cannabis use was not significantly associated with increased incidence of MDD (Adjusted Odds Ratio (AOR) for daily use=0.58(0.22-1.51)). Weekly to almost daily cannabis use was associated with increased incidence of BPD ((AOR for weekly to daily use=2.47(1.03-5.92)); daily use was not (AOR=0.52(0.17-1.55)). Baseline MDD was associated with initiation of cannabis use (AOR=1.72(1.1-2.69)). A crude association between baseline BPD and incidence of cannabis use was not maintained in adjusted models (AOR=0.61(0.36-1.04)).. Lack of information regarding frequency of cannabis use at follow-up and limitations regarding generalization of the results.. Our findings do not support a longitudinal association between cannabis use and incidence of MDD. Results regarding the association between cannabis use and incidence of BPD are conflicting and require further investigation. Baseline MDD, but not BPD, may be associated with future initiation of cannabis use. This may have implications for clinical, social and legislative aspects of cannabis use.

Topics: Adult; Alcohol-Related Disorders; Bipolar Disorder; Cannabis; Causality; Female; Humans; Incidence; Longitudinal Studies; Male; Marijuana Abuse; Middle Aged; Mood Disorders; Odds Ratio; Prospective Studies; Substance-Related Disorders; Young Adult

Previous population-based studies have found that delusional-like experiences (DLE) are prevalent in the community, and are associated with a wide range of mental health disorders including substance use. The aim of the study was to explore the association between DLE and three commonly used substances--tobacco, alcohol and cannabis.. Subjects were drawn from the Australian National Survey of Mental Health and Wellbeing 2007. The Composite International Diagnostic Interview was used to identify DLE, common psychiatric disorders, and substance use. We examined the relationship between the variables of interest using logistic regression, adjusting for potential confounding factors.. Of 8,773 participants, 8.4% (n=776) subjects endorsed one or more DLE. With respect to tobacco use, compared to nonusers, DLE were more common in those who (a) had daily use, (b) commenced usage aged 15 years or less, and (c) those who smoked heavily (23 or more cigarettes per day). Participants with cannabis use disorders were more likely to endorse DLE; this association was most prominent in those with an onset of 16 years or younger. In contrast, the pattern of association between DLE versus alcohol use or dependence was less consistent, however those with early onset alcohol use disorders were more likely to endorse DLE probe items.. While cannabis use disorders have been previously linked with DLE, our findings linking alcohol and tobacco use and DLE suggest that the influence of these substances on psychosis-related outcomes warrants closer scrutiny in longitudinal prospective studies.

Topics: Adolescent; Adult; Aged; Alcohol Drinking; Alcohol-Related Disorders; Cannabis; Delusions; Female; Humans; Longitudinal Studies; Male; Marijuana Smoking; Middle Aged; Prevalence; Psychotic Disorders; Smoking; Substance-Related Disorders

Alcohol, tobacco, and illegal drug use cause considerable morbidity and mortality, but good cross-national epidemiological data are limited. This paper describes such data from the first 17 countries participating in the World Health Organization's (WHO's) World Mental Health (WMH) Survey Initiative.. Household surveys with a combined sample size of 85,052 were carried out in the Americas (Colombia, Mexico, United States), Europe (Belgium, France, Germany, Italy, Netherlands, Spain, Ukraine), Middle East and Africa (Israel, Lebanon, Nigeria, South Africa), Asia (Japan, People's Republic of China), and Oceania (New Zealand). The WHO Composite International Diagnostic Interview (CIDI) was used to assess the prevalence and correlates of a wide variety of mental and substance disorders. This paper focuses on lifetime use and age of initiation of tobacco, alcohol, cannabis, and cocaine. Alcohol had been used by most in the Americas, Europe, Japan, and New Zealand, with smaller proportions in the Middle East, Africa, and China. Cannabis use in the US and New Zealand (both 42%) was far higher than in any other country. The US was also an outlier in cocaine use (16%). Males were more likely than females to have used drugs; and a sex-cohort interaction was observed, whereby not only were younger cohorts more likely to use all drugs, but the male-female gap was closing in more recent cohorts. The period of risk for drug initiation also appears to be lengthening longer into adulthood among more recent cohorts. Associations with sociodemographic variables were consistent across countries, as were the curves of incidence of lifetime use.. Globally, drug use is not distributed evenly and is not simply related to drug policy, since countries with stringent user-level illegal drug policies did not have lower levels of use than countries with liberal ones. Sex differences were consistently documented, but are decreasing in more recent cohorts, who also have higher levels of illegal drug use and extensions in the period of risk for initiation.

Topics: Adolescent; Adult; Alcohol-Related Disorders; Cannabis; Cocaine-Related Disorders; Cohort Studies; Female; Global Health; Health Surveys; Humans; Internationality; Male; Marijuana Abuse; Mental Health; Tobacco Use Disorder; World Health Organization

Epidemiological studies of illegal drug use in adolescents have examined frequency of drug use; a few have examined diagnoses or symptoms of drug abuse or dependence. This study examined problem use of illegal drugs, about which very little is known.. Adolescents (879 boys and 929 girls), mean age of 15.7 years, representative of the province of Québec, Canada, were asked about problem use of alcohol and illegal drugs.. Almost one third had used illegal drugs more than 5 times. Of this group, more than 70% reported going to school high on drugs, and the majority reported playing sports while high and using drugs in the morning. In these drugs users, 94% of the boys and 85% of the girls reported at least 1 problem and two thirds of the boys and more than half of the girls reported 3 or more problems from illegal drugs. Marijuana was used by almost all subjects at the time of maximal drug use; hallucinogens were the second most commonly used drug. Alcohol was used more frequently than illegal drugs, but problem use was less common.. Problem drug use is the norm among the large minority who use illegal drugs more than a few times, and drug use is commonly incorporated into 2 major routine activities of teenagers--school and sports.

Topics: Adolescent; Adolescent Behavior; Alcohol-Related Disorders; Canada; Cannabis; Female; Hallucinogens; Health Surveys; Humans; Longitudinal Studies; Male; Prevalence; Quebec; Sampling Studies; Self Disclosure; Sex Factors; Substance-Related Disorders

This study examined the relationship between depressive symptoms and polydrug use (alcohol, marijuana, and cocaine) among blacks in a high-risk community.. A street sample (N = 570) from four high-risk communities in Birmingham, Alabama, was collected through personal interviews. Interviewers asked respondents about their drug use behavior during the past 30 days, as well as about their depressive symptoms during the past week.. Odds ratios and logistic regressions, adjusted for age and sex, were used to assess the relationship between depressive symptoms and drug and polydrug use (drug use involving cocaine). Results showed that depressive symptoms are significantly associated with polydrug use. However, depressive symptoms were not associated with alcohol use or with the combination of alcohol and marijuana use.. Depressive symptoms are related to polydrug use involving cocaine, though the causal relationship is uncertain. Previous reports on depressive symptoms and alcohol or marijuana may be inconclusive.

Topics: Adult; Age Factors; Alabama; Alcohol-Related Disorders; Black or African American; Cannabis; Cocaine; Depression; Environment; Female; HIV Infections; Humans; Interview, Psychological; Logistic Models; Male; Narcotics; Odds Ratio; Prevalence; Risk Factors; Sex Factors; Sexually Transmitted Diseases; Social Problems; Substance-Related Disorders