humulene and Acute-Coronary-Syndrome

Phytogenic cannabinoids from

Topics: Acute Coronary Syndrome; Animals; Arrhythmias, Cardiac; Cannabinoid Receptor Agonists; Cannabinoids; Cannabis; Cardiotoxicity; Heart; Heart Rate; Humans; Marijuana Abuse; Marijuana Smoking; Receptors, Cannabinoid; Risk Assessment; Risk Factors; Signal Transduction

Marijuana consumption is growing up becoming very common especially between young people. 9-THC, the main psychoactive compound in cannabis, acts on the endocannabinoid system having different cardiovascular effects, including arrhythmias, acute coronary syndrome, and sudden cardiac death. We present the case of a young man from Gambia with no cardiovascular risk factors, marijuana consumer, presenting to the emergency department with ST-elevation myocardial infarction. At coronary angiography, thrombotic left anterior descending coronary artery subocclusion was documented. We also describe the association between acute coronary syndrome and cannabis abuse.

Topics: Acute Coronary Syndrome; Adolescent; Cannabis; Coronary Angiography; Coronary Thrombosis; Coronary Vessels; Humans; Male; Marijuana Abuse; ST Elevation Myocardial Infarction

Acute coronary syndrome (ACS) is the usual clinical entry point for coronary heart disease. France is the European country with the highest prevalence of cannabis use and an increase in serious cardiovascular complications, including infarction, related to cannabis. The main objective was to compare the clinical and cardiological profile of patients with ACS according to exposure to cannabis use.. We conducted a retrospective, single-centre, exposure-non-exposure cohort study of all adult patients (> 18 years) admitted for ACS in the ICU between January 1, 2012 and December 31, 2021 at the Centre Hospitalier de Troyes, with mention of cannabis use in the medical record. A matching was performed so that each patient identified in the exposed group was associated with a comparable unexposed patient on age, sex, period of hospitalisation and cardiovascular event typology (type of ACS and topography for ST+).. 2745 patients admitted to the ICU and the coronary angiography room presented an ST+ or ST- ACS from 01/01/2012 to 31/12/2021 at the CHT. For 31 patients of them (1.1%), we noted cannabis consumption, which concern 7,9% of SCA ST+ aged under 50.. The link between cannabis use and ACS is established, but studies concerning the place of cannabis in the ACS pathway of an ICU are few in France. Our results show the interest of developing a specific pathway focused on the needs of patients and their specificities in post ACS management.

Topics: Acute Coronary Syndrome; Adult; Aged; Cannabis; Cohort Studies; Coronary Angiography; Humans; Retrospective Studies; Risk Factors

Due to legalization of its consumption in some countries and its medical use as well as low toxic potential, cannabis remains the most widely used drug around the world and the rate of usage is only increasing.  Nevertheless, there are several case reports of vascular complications following cannabis use even in young people without cardiovascular risk factors. We report the case of a cannabis smoker presenting to the emergency room for an ischemic stroke associated with an acute coronary syndrome related to a spontaneous simultaneous double dissection of the carotid artery and the left anterior descending artery, with a favourable outcome under medical treatment. This case shows the seriousness of complications due to the cannabis consumption, hence the need to limit or even prohibit its consumption.

Topics: Acute Coronary Syndrome; Adolescent; Cannabis; Carotid Arteries; Dissection; Humans; Stroke

Marijuana is one of the most commonly consumed psychotropic drugs in the world. It has been associated with adverse cardiovascular reactions including acute coronary syndrome, but this information is not widely known among emergency medicine clinicians. This article describes cannabis use as a contributing factor to acute myocardial infarction in a young woman with chest pain.

Topics: Acute Coronary Syndrome; Adult; Cannabis; Chest Pain; Drug-Eluting Stents; Electrocardiography; Endovascular Procedures; Female; Humans; Marijuana Abuse; Myocardial Infarction; Patient Compliance; Patient Education as Topic

Topics: Acute Coronary Syndrome; Adult; Cannabis; Chest Pain; Cholesterol; Coronary Angiography; Coronary Artery Disease; Diagnosis, Differential; Dyslipidemias; Humans; Male

Nowadays cannabis is the most common substance of drug abuse and pathophysiological effects have been described on the cardiovascular system. Yet there is limited information concerning cannabis induced acute coronary syndrome and the exact contribution of cannabis smoking to coronary artery disease and its mechanism are not known. We describe a case of acute coronary syndrome following cannabis smoking in a young female with no predisposing causes for thrombosis.

Topics: Acute Coronary Syndrome; Adult; Cannabis; Coronary Vasospasm; Female; Humans; Marijuana Smoking