hts-466284 and Seizures

hts-466284 has been researched along with Seizures* in 1 studies

Other Studies

1 other study(ies) available for hts-466284 and Seizures

Article	Year
NKCC1 up-regulation contributes to early post-traumatic seizures and increased post-traumatic seizure susceptibility. Brain structure & function, 2017, Volume: 222, Issue:3 Traumatic brain injury (TBI) is not only a leading cause for morbidity and mortality in young adults (Bruns and Hauser, Epilepsia 44(Suppl 10):210, 2003), but also a leading cause of seizures. Understanding the seizure-inducing mechanisms of TBI is of the utmost importance, because these seizures are often resistant to traditional first- and second-line anti-seizure treatments. The early post-traumatic seizures, in turn, are a contributing factor to ongoing neuropathology, and it is critically important to control these seizures. Many of the available anti-seizure drugs target gamma-aminobutyric acid (GABA Topics: Ammonia; Animals; Animals, Newborn; Bumetanide; Cell Count; Cerebral Cortex; Disease Models, Animal; Epilepsy, Post-Traumatic; Evoked Potentials; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Phosphopyruvate Hydratase; Pyrazoles; Pyrroles; Seizures; Sodium Potassium Chloride Symporter Inhibitors; Solute Carrier Family 12, Member 2; Up-Regulation; Wakefulness	2017

Article

Year

NKCC1 up-regulation contributes to early post-traumatic seizures and increased post-traumatic seizure susceptibility.

Brain structure & function, 2017, Volume: 222, Issue:3

Traumatic brain injury (TBI) is not only a leading cause for morbidity and mortality in young adults (Bruns and Hauser, Epilepsia 44(Suppl 10):210, 2003), but also a leading cause of seizures. Understanding the seizure-inducing mechanisms of TBI is of the utmost importance, because these seizures are often resistant to traditional first- and second-line anti-seizure treatments. The early post-traumatic seizures, in turn, are a contributing factor to ongoing neuropathology, and it is critically important to control these seizures. Many of the available anti-seizure drugs target gamma-aminobutyric acid (GABA

Topics: Ammonia; Animals; Animals, Newborn; Bumetanide; Cell Count; Cerebral Cortex; Disease Models, Animal; Epilepsy, Post-Traumatic; Evoked Potentials; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Phosphopyruvate Hydratase; Pyrazoles; Pyrroles; Seizures; Sodium Potassium Chloride Symporter Inhibitors; Solute Carrier Family 12, Member 2; Up-Regulation; Wakefulness

2017