homovanillic acid has been researched along with Muscle Rigidity in 20 studies
Homovanillic Acid: A 3-O-methyl ETHER of (3,4-dihydroxyphenyl)acetic acid.
homovanillate : A hydroxy monocarboxylic acid anion which is obtained by deprotonation of the carboxy group of homovanillic acid.
homovanillic acid : A monocarboxylic acid that is the 3-O-methyl ether of (3,4-dihydroxyphenyl)acetic acid. It is a catecholamine metabolite.
Muscle Rigidity: Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected muscle is passively stretched, the degree of resistance remains constant regardless of the rate at which the muscle is stretched. This feature helps to distinguish rigidity from MUSCLE SPASTICITY. (From Adams et al., Principles of Neurology, 6th ed, p73)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Oral administration of 10% solution of Phytomix-40 (multicomponent plant phytoadaptogen) to C57Bl/6 mice with MPTP-induced Parkinson's syndrome alleviated symptoms (oligokinesia and muscle rigidity), compensated for the deficiency of dopamine and its metabolites (DOPAC and homovanillic acid), and reduced the level of lipid peroxides in the striatum." | 3.73 | Effect of complex phytoadaptogen on MPTP-induced Parkinson's syndrome in mice. ( Belorustseva, SA; Bocharov, EV; Bocharova, OA; Kryzhanovskii, GN; Kucheryanu, VG; Kudrin, VS, 2006) |
| " Behavioral deficits at the end of the 14-day dosing regime and on day 28 (i." | 1.40 | Intranasal administration of alpha-synuclein aggregates: a Parkinson's disease model with behavioral and neurochemical correlates. ( Davydova, TV; Fomina, VG; Gruden, MA; Kudrin, VS; Morozova-Roche, LA; Narkevich, VB; Sewell, RD; Wang, C, 2014) |
| "Seven cases of the infantile form of Huntington's disease--six boys and one girl--were observed in the space of six years." | 1.26 | Seven cases of Huntington's disease in childhood and levodopa induced improvement in the hypokinetic--rigid form. ( Gabreëls, FJ; Jongen, PJ; Renier, WO, 1980) |
| "Twenty-seven patients with Parkinson's disease participated in a double-blind crossover trial of L-dopa and amantadine." | 1.25 | Interactions of L-dopa and amantadine in patients with Parkinsonism. ( Cox, B; Danta, G; Schnieden, H; Yuill, GM, 1973) |
| "Six patients diagnosed as Parkinson's disease on a clinical basis alone are described, and their response to L-dopa and to alpha methyl dopa hydrazine (MK 486) and L-dopa." | 1.25 | An analysis of six patients with Parkinson's disease who have been unresponsive to L-dopa therapy. ( Mones, RJ, 1973) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (50.00) | 18.7374 |
| 1990's | 4 (20.00) | 18.2507 |
| 2000's | 3 (15.00) | 29.6817 |
| 2010's | 3 (15.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gruden, MA | 1 |
| Davydova, TV | 1 |
| Narkevich, VB | 1 |
| Fomina, VG | 1 |
| Wang, C | 1 |
| Kudrin, VS | 3 |
| Morozova-Roche, LA | 1 |
| Sewell, RD | 1 |
| Humphreys, P | 1 |
| Barrowman, N | 1 |
| Lin, JW | 1 |
| Shih, CM | 1 |
| Chen, YC | 1 |
| Lin, CM | 1 |
| Tsai, JT | 1 |
| Chiang, YH | 1 |
| Shih, R | 1 |
| Chiu, PL | 1 |
| Hung, KS | 1 |
| Yeh, YS | 1 |
| Wei, L | 1 |
| Chiu, WT | 1 |
| Yang, LY | 1 |
| Willemsen, MA | 1 |
| Verbeek, MM | 1 |
| Kamsteeg, EJ | 1 |
| de Rijk-van Andel, JF | 1 |
| Aeby, A | 1 |
| Blau, N | 1 |
| Burlina, A | 1 |
| Donati, MA | 1 |
| Geurtz, B | 1 |
| Grattan-Smith, PJ | 1 |
| Haeussler, M | 1 |
| Hoffmann, GF | 1 |
| Jung, H | 1 |
| de Klerk, JB | 1 |
| van der Knaap, MS | 1 |
| Kok, F | 1 |
| Leuzzi, V | 1 |
| de Lonlay, P | 1 |
| Megarbane, A | 1 |
| Monaghan, H | 1 |
| Renier, WO | 2 |
| Rondot, P | 1 |
| Ryan, MM | 1 |
| Seeger, J | 1 |
| Smeitink, JA | 1 |
| Steenbergen-Spanjers, GC | 1 |
| Wassmer, E | 1 |
| Weschke, B | 1 |
| Wijburg, FA | 1 |
| Wilcken, B | 1 |
| Zafeiriou, DI | 1 |
| Wevers, RA | 1 |
| Bocharov, EV | 1 |
| Kucheryanu, VG | 1 |
| Kryzhanovskii, GN | 2 |
| Bocharova, OA | 1 |
| Belorustseva, SA | 1 |
| Jongen, PJ | 1 |
| Gabreëls, FJ | 1 |
| Kucherianu, VG | 1 |
| Iurasov, VV | 1 |
| Nikushkin, EV | 1 |
| Zhigal'tsev, IV | 1 |
| Antkiewicz-Michaluk, L | 1 |
| Michaluk, J | 1 |
| Mokrosz, M | 1 |
| Romanska, I | 1 |
| Lorenc-Koci, E | 1 |
| Ohta, S | 1 |
| Vetulani, J | 1 |
| Calderini, G | 1 |
| Consolazione, A | 1 |
| Garattini, S | 1 |
| Algeri, S | 1 |
| McLellan, DL | 1 |
| Chalmers, RJ | 1 |
| Johnson, RH | 1 |
| Schmidt, RT | 1 |
| Stahl, SM | 1 |
| Spehlmann, R | 1 |
| Soininen, H | 1 |
| Laulumaa, V | 1 |
| Helkala, EL | 1 |
| Hartikainen, P | 1 |
| Riekkinen, PJ | 1 |
| Jolicoeur, FB | 1 |
| Rivest, R | 1 |
| Drumheller, A | 1 |
| Tyrrell, PJ | 1 |
| Sawle, GV | 1 |
| Ibanez, V | 1 |
| Bloomfield, PM | 1 |
| Leenders, KL | 1 |
| Frackowiak, RS | 1 |
| Rossor, MN | 1 |
| West, KA | 1 |
| Roos, BE | 1 |
| Ahtee, L | 1 |
| Kääriäinen, I | 1 |
| Paasonen, MK | 1 |
| Cox, B | 1 |
| Danta, G | 1 |
| Schnieden, H | 1 |
| Yuill, GM | 1 |
| Mones, RJ | 1 |
| Chase, TN | 1 |
| Woods, AC | 1 |
| Glaubiger, GA | 1 |
| Parkes, JD | 1 |
| Marsden, CD | 1 |
| Rees, JE | 1 |
| Curzon, G | 1 |
| Kantamaneni, BD | 1 |
| Knill-Jones, R | 1 |
| Akbar, A | 1 |
| Das, S | 1 |
| Kataria, M | 1 |
2 trials available for homovanillic acid and Muscle Rigidity
| Article | Year |
|---|---|
Clinical and pharmacological evaluation of the effects of piribedil in patients with parkinsonism.
Topics: Aged; Antiparkinson Agents; Chorea; Clinical Trials as Topic; Confusion; Dioxoles; Dopamine; Drug Ev | 1975 |
Parkinson disease treated with a suspected dopamine receptor agonist.
Topics: Adult; Aged; Amantadine; Aromatic Amino Acid Decarboxylase Inhibitors; Benztropine; Dihydroxyphenyla | 1974 |
18 other studies available for homovanillic acid and Muscle Rigidity
| Article | Year |
|---|---|
Intranasal administration of alpha-synuclein aggregates: a Parkinson's disease model with behavioral and neurochemical correlates.
Topics: 3,4-Dihydroxyphenylacetic Acid; Administration, Intranasal; alpha-Synuclein; Amyloid; Animals; Corpu | 2014 |
The Incidence and Evolution of Parkinsonian Rigidity in Rett Syndrome: A Pilot Study.
Topics: Adolescent; Adult; Child; Child, Preschool; Female; Homovanillic Acid; Humans; Indoles; Male; Methyl | 2016 |
Biochemical alteration in cerebrospinal fluid precedes behavioral deficits in Parkinsonian rats induced by 6-hydroxydopamine.
Topics: Animals; Biomarkers; Cell Count; Cell Death; Disease Models, Animal; Dopamine; Homovanillic Acid; Hy | 2009 |
Tyrosine hydroxylase deficiency: a treatable disorder of brain catecholamine biosynthesis.
Topics: Age of Onset; Amino Acid Metabolism, Inborn Errors; Brain; Brain Diseases; Catecholamines; Child, Pr | 2010 |
Effect of complex phytoadaptogen on MPTP-induced Parkinson's syndrome in mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Chromatography, High Pressure Liquid; Corpus Striatum; Dopa | 2006 |
Seven cases of Huntington's disease in childhood and levodopa induced improvement in the hypokinetic--rigid form.
Topics: Adolescent; Child; Child, Preschool; Female; Homovanillic Acid; Humans; Huntington Disease; Hydroxyi | 1980 |
[Effect of acidic fibroblast growth factor on experimental parkinsonism and levels of dopamine and its metabolites in the striatum of mice of various ages].
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Administration, Intran | 1999 |
Different action on dopamine catabolic pathways of two endogenous 1,2,3,4-tetrahydroisoquinolines with similar antidopaminergic properties.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Dopamine Antagonists; Homovanill | 2001 |
Different effects of methionine-enkephalin and (D-Ala2)methionine-enkephalin amide on the metabolism of dopamine and norephinephrine in rat brain:fact or artifact?
Topics: 3,4-Dihydroxyphenylacetic Acid; Amino Acid Sequence; Animals; Behavior, Animal; Brain; Dopamine; End | 1978 |
A pharmacologic study of the stiff-man syndrome. Correlation of clinical symptoms with urinary 3-methoxy-4-hydroxy-phenyl glycol excretion.
Topics: Diazepam; Glycine; Glycols; Homovanillic Acid; Humans; Levodopa; Male; Metanephrine; Methoxyhydroxyp | 1975 |
Extrapyramidal signs in Alzheimer's disease: a 3-year follow-up study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antipsychotic Agents; Basal Ganglia Diseases; Dopamine; | 1992 |
Hypokinesia, rigidity, and tremor induced by hypothalamic 6-OHDA lesions in the rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Dopamine; Dyskinesia, Drug-Induced; Homovanillic Aci | 1991 |
Clinical and positron emission tomographic studies in the 'extrapyramidal syndrome' of dementia of the Alzheimer type.
Topics: Adult; Aged; Alzheimer Disease; Caudate Nucleus; Dementia; Dopamine; Homovanillic Acid; Humans; Midd | 1990 |
The ventricular fluid pressure and the concentration of homovanillic acid in different parts of the cerebrospinal fluid system in patients with Parkinson's disease.
Topics: Aged; Cerebral Ventricles; Dopamine; Female; Homovanillic Acid; Humans; Intracranial Pressure; Male; | 1972 |
Effect of nalorphine and antiparkinsonian drugs on methadone-induced rigidity; relation to homovanillic acid content of nucleus caudatus.
Topics: Amantadine; Animals; Atropine; Body Temperature; Brain; Caudate Nucleus; Depression, Chemical; Dose- | 1972 |
Interactions of L-dopa and amantadine in patients with Parkinsonism.
Topics: Amantadine; Dihydroxyphenylalanine; Drug Interactions; Evaluation Studies as Topic; Female; Homovani | 1973 |
An analysis of six patients with Parkinson's disease who have been unresponsive to L-dopa therapy.
Topics: Aged; Carbidopa; Diagnosis, Differential; Dihydroxyphenylalanine; Evaluation Studies as Topic; Femal | 1973 |
Parkinson's disease, cerebral arteriosclerosis, and senile dementia. Clinical features and response to levodopa.
Topics: Aged; Dementia; Dihydroxyphenylalanine; Electroencephalography; Female; Gait; Homovanillic Acid; Hum | 1974 |