homovanillic acid has been researched along with Lesch-Nyhan Syndrome in 8 studies
Homovanillic Acid: A 3-O-methyl ETHER of (3,4-dihydroxyphenyl)acetic acid.
homovanillate : A hydroxy monocarboxylic acid anion which is obtained by deprotonation of the carboxy group of homovanillic acid.
homovanillic acid : A monocarboxylic acid that is the 3-O-methyl ether of (3,4-dihydroxyphenyl)acetic acid. It is a catecholamine metabolite.
Lesch-Nyhan Syndrome: An inherited disorder transmitted as a sex-linked trait and caused by a deficiency of an enzyme of purine metabolism; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE. Affected individuals are normal in the first year of life and then develop psychomotor retardation, extrapyramidal movement disorders, progressive spasticity, and seizures. Self-destructive behaviors such as biting of fingers and lips are seen frequently. Intellectual impairment may also occur but is typically not severe. Elevation of uric acid in the serum leads to the development of renal calculi and gouty arthritis. (Menkes, Textbook of Child Neurology, 5th ed, pp127)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a patient with the Lesch-Nyhan syndrome we found decreased spinal fluid 5-hydroxyindole acetic acid (5-HIAA), the major metabolite of serotonin, and decreased homovanillic acid (HVA), the major metabolite of dopamine, indicating a decrease in monoamine metabolism." | 7.66 | Effects of L-5-hydroxytryptophan on monoamine and amino acids turnover in the Lesch-Nyhan syndrome. ( Castells, S; Chakrabarti, C; Hurwic, M; Nyhan, WL; Perel, JM; Winsberg, BG, 1979) |
| "The effects of 5-hydroxytryptophan (5-HTP), a serotonin precursor, were studied in a boy with the Lesch-Nyhan syndrome." | 7.65 | The use of 5-hydroxytryptophan in a child with Lesch-Nyhan syndrome. ( Anders, TF; Barchas, JD; Berger, PA; Cann, HM; Ciaranello, RD, 1976) |
| "Serial determinations of spinal fluid homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) were made in four patients with the Lesch-Nyhan syndrome over a 5-year period." | 3.67 | Lesch-Nyhan syndrome: CSF neurotransmitter abnormalities. ( Edwards, NL; Hutchinson, RJ; Johnston, MV; Silverstein, FS, 1985) |
| "In a patient with the Lesch-Nyhan syndrome we found decreased spinal fluid 5-hydroxyindole acetic acid (5-HIAA), the major metabolite of serotonin, and decreased homovanillic acid (HVA), the major metabolite of dopamine, indicating a decrease in monoamine metabolism." | 3.66 | Effects of L-5-hydroxytryptophan on monoamine and amino acids turnover in the Lesch-Nyhan syndrome. ( Castells, S; Chakrabarti, C; Hurwic, M; Nyhan, WL; Perel, JM; Winsberg, BG, 1979) |
| "The effects of 5-hydroxytryptophan (5-HTP), a serotonin precursor, were studied in a boy with the Lesch-Nyhan syndrome." | 3.65 | The use of 5-hydroxytryptophan in a child with Lesch-Nyhan syndrome. ( Anders, TF; Barchas, JD; Berger, PA; Cann, HM; Ciaranello, RD, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (62.50) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tschirner, SK | 1 |
| Gutzki, F | 1 |
| Kaever, V | 1 |
| Seifert, R | 1 |
| Schneider, EH | 1 |
| Bavaresco, CS | 1 |
| Chiarani, F | 1 |
| Duringon, E | 1 |
| Ferro, MM | 1 |
| Cunha, CD | 1 |
| Netto, CA | 1 |
| Wyse, AT | 1 |
| Smith, DW | 1 |
| Jinnah, HA | 1 |
| Castells, S | 1 |
| Chakrabarti, C | 1 |
| Winsberg, BG | 1 |
| Hurwic, M | 1 |
| Perel, JM | 1 |
| Nyhan, WL | 1 |
| Ciaranello, RD | 1 |
| Anders, TF | 1 |
| Barchas, JD | 1 |
| Berger, PA | 1 |
| Cann, HM | 1 |
| Edwards, NL | 2 |
| Silverstein, FS | 2 |
| Johnston, MV | 2 |
| Jankovic, J | 1 |
| Caskey, TC | 1 |
| Stout, JT | 1 |
| Butler, IJ | 1 |
| Hutchinson, RJ | 1 |
8 other studies available for homovanillic acid and Lesch-Nyhan Syndrome
| Article | Year |
|---|---|
Altered histamine neurotransmission in HPRT-deficient mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Dopamine; Histamine; Homovanillic Acid; Hypoxanthine | 2015 |
Intrastriatal injection of hypoxanthine reduces striatal serotonin content and impairs spatial memory performance in rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Homovanillic Acid; Hydroxyindole | 2007 |
Role of neuronal nitric oxide in the dopamine deficit of HPRT-deficient mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Dopamine; Female; Homovanillic Acid; Hypoxanthine Phosphori | 2007 |
Effects of L-5-hydroxytryptophan on monoamine and amino acids turnover in the Lesch-Nyhan syndrome.
Topics: 5-Hydroxytryptophan; Amino Acids; Carbidopa; Dopamine; Homovanillic Acid; Humans; Hydroxyindoleaceti | 1979 |
The use of 5-hydroxytryptophan in a child with Lesch-Nyhan syndrome.
Topics: 5-Hydroxytryptophan; Child, Preschool; Cold Temperature; Crying; Dopamine beta-Hydroxylase; Dose-Res | 1976 |
Purine and monoamine metabolites in cerebrospinal fluid.
Topics: Age Factors; Child; Child, Preschool; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Infant; I | 1986 |
Lesch-Nyhan syndrome: a study of motor behavior and cerebrospinal fluid neurotransmitters.
Topics: Carbidopa; Catecholamines; Child; Child, Preschool; Fluphenazine; Glycols; Homovanillic Acid; Humans | 1988 |
Lesch-Nyhan syndrome: CSF neurotransmitter abnormalities.
Topics: Adolescent; Child; Child, Preschool; Chromatography, High Pressure Liquid; Dopamine; Homovanillic Ac | 1985 |