homovanillic acid has been researched along with Epilepsy in 40 studies
Homovanillic Acid: A 3-O-methyl ETHER of (3,4-dihydroxyphenyl)acetic acid.
homovanillate : A hydroxy monocarboxylic acid anion which is obtained by deprotonation of the carboxy group of homovanillic acid.
homovanillic acid : A monocarboxylic acid that is the 3-O-methyl ether of (3,4-dihydroxyphenyl)acetic acid. It is a catecholamine metabolite.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cerebrospinal fluid (CSF) concentrations of 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA) and probenecid were examined in 14 children with epilepsy (ages 6 months to 17 years) and 17 controls (ages 14 months to 16 years)." | 7.65 | Reduced cerebrospinal fluid 5-hydroxyindoleacetic acid and homovanillic acid in children with epilepsy. ( Bowers, MB; Cohen, DJ; Shaywitz, BA, 1975) |
| "The concentration of dopamine (DA) metabolite-homovanillic acid (HVA) in cerebrospinal fluid (CSF) of 40 patients with schizophrenia 27 with epilepsy and 15 controls without disorders of CNS was reported." | 3.70 | [Study on dopamine metabolite in cerebrospinal fluid of schizophrenics and epilepsics]. ( Chen, X; Jiang, S; Liao, W, 1998) |
| " Vigabatrin, 50 mg kg-1, was administered orally as add-on therapy to 11 patients with drug-resistant complex partial epilepsy as a single dose, then once every third day for 2 months, every other day for 2 months and daily for 1 month." | 3.67 | The effect of different vigabatrin treatment regimens on CSF biochemistry and seizure control in epileptic patients. ( Ben-Menachem, E; Dahlgren, L; Haegele, KD; Hardenberg, J; Huebert, N; Mumford, JP; Persson, LI; Schechter, PJ, 1989) |
| "Maturation of monoamine neuronal systems was studied by measuring cerebrospinal fluid metabolites of dopamine (homovanillic acid) and serotonin (5-hydroxyindoleacetic acid) in 38 children with epilepsy and other neurological disorders, to whom probenecid had previously been administered." | 3.66 | Ontogeny of dopamine and serotonin metabolites in the cerebrospinal fluid of children with neurological disorders. ( Bowers, MB; Cohen, DJ; Leckman, JF; Shaywitz, BA; Young, JG, 1980) |
| "To assess the possible role of amine neurotransmitters in human epilepsy, we measured metabolites of serotonin (5-hydroxyindoleacetic acid [5-HIAA]), dopamine (homovanillic acid [HVA]), and norepinephrine (3-methoxy-4-hydroxyphenylethylene glycol [MHPG]) in the lumbar cerebrospinal fluid (CSF) of patients with partial complex seizures and in neurologic controls." | 3.66 | Monoamine metabolites in the CSF of epileptic patients. ( Fang, TY; Gauthier, SG; Laxer, KD; Missala, K; Sourkes, TL; Young, SN, 1979) |
| "Cerebrospinal fluid (CSF) concentrations of 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA) and probenecid were examined in 14 children with epilepsy (ages 6 months to 17 years) and 17 controls (ages 14 months to 16 years)." | 3.65 | Reduced cerebrospinal fluid 5-hydroxyindoleacetic acid and homovanillic acid in children with epilepsy. ( Bowers, MB; Cohen, DJ; Shaywitz, BA, 1975) |
| "In 6 patients with intention myoclonus, the cerebrospinal fluid concentration of 5-hydroxyindoleacetic acid, a metabolite of serotonin was found to be significantly decreased." | 2.64 | Serotonin and myoclonus. ( Bowers, MB; Jutkowitz, R; Rosenbaum, D; Van Woert, MH, 1976) |
| "The 18 patients had either West syndrome (12 patients) or Lennox-Gastaut syndrome (6 patients), which was intractable to antiepileptic drug therapy and to adrenocorticotrophic hormone." | 1.29 | Thyrotropin-releasing hormone in treatment of intractable epilepsy: neurochemical analysis of CSF monoamine metabolites. ( Kawase, S; Matsuo, S; Mitsufuji, N; Nishimura, A; Sawada, T; Takeuchi, Y; Tominaga, M; Yamazoe, I, 1995) |
| "The Rett syndrome is a progressive disorder in female patients that is characterized by autistic behavior, dementia, ataxia, loss of purposeful use of the hands, and seizures." | 1.27 | Reduction of biogenic amine levels in the Rett syndrome. ( Butler, IJ; Glaze, DG; Percy, AK; Riccardi, VM; Zoghbi, HY, 1985) |
| "Transient hyperkinesia was observed in a 16-year-old epileptic and mentally retarded patient after a single intravenous perfusion of diphenylhydantoin (DPH)." | 1.26 | Transient hyperkinesia after a single intravenous perfusion of diphenylhydantoin. Report of a case associated with nontoxic plasma levels of diphenylhydantoin. ( Courjon, J; Dalery, J; de Villard, R; Mauguière, F, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (67.50) | 18.7374 |
| 1990's | 8 (20.00) | 18.2507 |
| 2000's | 4 (10.00) | 29.6817 |
| 2010's | 1 (2.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Horvath, GA | 1 |
| Demos, M | 1 |
| Shyr, C | 1 |
| Matthews, A | 1 |
| Zhang, L | 1 |
| Race, S | 1 |
| Stockler-Ipsiroglu, S | 1 |
| Van Allen, MI | 1 |
| Mancarci, O | 1 |
| Toker, L | 1 |
| Pavlidis, P | 1 |
| Ross, CJ | 1 |
| Wasserman, WW | 1 |
| Trump, N | 1 |
| Heales, S | 2 |
| Pope, S | 1 |
| Cross, JH | 1 |
| van Karnebeek, CD | 1 |
| Crawley, F | 1 |
| Rudge, P | 1 |
| Chanut, E | 1 |
| Labarthe, B | 1 |
| Lacroix, B | 1 |
| Noda, A | 1 |
| Gasdeblay, S | 1 |
| Bondier, JR | 1 |
| Versaux-Botteri, C | 1 |
| García-Cazorla, A | 1 |
| Serrano, M | 1 |
| Pérez-Dueñas, B | 1 |
| González, V | 1 |
| Ormazábal, A | 2 |
| Pineda, M | 1 |
| Fernández-Alvarez, E | 1 |
| Campistol, JM | 1 |
| Artuch, RM | 1 |
| Ruiz, A | 1 |
| García-Villoria, J | 1 |
| Zschocke, J | 1 |
| Fiol, M | 1 |
| Navarro-Sastre, A | 1 |
| Artuch, R | 1 |
| Vilaseca, MA | 1 |
| Ribes, A | 1 |
| Shaywitz, BA | 4 |
| Cohen, DJ | 3 |
| Leckman, JF | 1 |
| Young, JG | 1 |
| Bowers, MB | 3 |
| Mohan, A | 1 |
| Nag, D | 1 |
| Misra, RN | 1 |
| Gujrati, VR | 1 |
| Shanker, K | 1 |
| Doval, DC | 1 |
| Saxena, RC | 1 |
| Bhargava, KP | 1 |
| Baliga, L | 1 |
| Rao, A | 1 |
| Raja, A | 1 |
| Rao, SN | 1 |
| Anderson, GM | 1 |
| Novotny, EJ | 1 |
| Ebersole, JS | 1 |
| Sullivan, CM | 1 |
| Gillespie, SM | 1 |
| Takeuchi, Y | 1 |
| Tominaga, M | 1 |
| Mitsufuji, N | 1 |
| Yamazoe, I | 1 |
| Kawase, S | 1 |
| Nishimura, A | 1 |
| Matsuo, S | 1 |
| Sawada, T | 1 |
| Kobayashi, K | 4 |
| Kawashima, K | 1 |
| Kawashima, Y | 1 |
| Yamamura, T | 1 |
| Kuse, H | 1 |
| Asano, Y | 1 |
| Kawai, Y | 1 |
| Hori, M | 1 |
| Okaniwa, A | 1 |
| Serikawa, T | 1 |
| Jiang, S | 1 |
| Chen, X | 1 |
| Liao, W | 1 |
| Laxer, KD | 1 |
| Sourkes, TL | 1 |
| Fang, TY | 1 |
| Young, SN | 2 |
| Gauthier, SG | 1 |
| Missala, K | 1 |
| Chadwick, D | 4 |
| Jenner, P | 4 |
| Reynolds, EH | 4 |
| Nagao, T | 1 |
| Fujimoto, A | 1 |
| Ohshimo, T | 1 |
| Yamamoto, M | 1 |
| Kugoh, T | 1 |
| Akiyama, K | 1 |
| Otsuki, S | 1 |
| Carrieri, P | 1 |
| Orefice, G | 1 |
| Mandarini, A | 1 |
| Rossi, V | 1 |
| Campanella, G | 1 |
| Koide, Y | 1 |
| Doi, T | 1 |
| Kohsaka, M | 1 |
| Hosokawa, K | 2 |
| Oku, Y | 2 |
| Mori, A | 3 |
| Mauguière, F | 1 |
| Dalery, J | 1 |
| de Villard, R | 1 |
| Courjon, J | 1 |
| Mantovani, J | 1 |
| DeVivo, DC | 1 |
| Trimble, M | 1 |
| Driver, MV | 1 |
| Kariya, T | 1 |
| Van Woert, MH | 1 |
| Jutkowitz, R | 1 |
| Rosenbaum, D | 1 |
| Ebara, Y | 1 |
| Livrea, P | 1 |
| Di Reda, L | 1 |
| Puca, FM | 1 |
| Genco, S | 1 |
| Specchio, L | 1 |
| Papagno, G | 1 |
| Chanarin, I | 1 |
| Kabuto, H | 1 |
| Yokoi, I | 1 |
| Abed, WT | 1 |
| Botez, MI | 1 |
| Bonuccelli, U | 1 |
| Garant, D | 1 |
| Fariello, R | 1 |
| Zoghbi, HY | 1 |
| Percy, AK | 1 |
| Glaze, DG | 1 |
| Butler, IJ | 1 |
| Riccardi, VM | 1 |
| Lloyd, KG | 1 |
| Scatton, B | 1 |
| Voltz, C | 1 |
| Bryere, P | 1 |
| Valin, A | 1 |
| Naquet, R | 1 |
| Ben-Menachem, E | 1 |
| Persson, LI | 1 |
| Schechter, PJ | 1 |
| Haegele, KD | 1 |
| Huebert, N | 1 |
| Hardenberg, J | 1 |
| Dahlgren, L | 1 |
| Mumford, JP | 1 |
| Louw, D | 1 |
| Sutherland, GR | 1 |
| Glavin, GB | 1 |
| Girvin, J | 1 |
| Kimiya, S | 1 |
| Seki, T | 1 |
| Maezawa, M | 1 |
| Yamada, T | 1 |
| Tachibana, Y | 1 |
| Klimowicz-Młodzik, I | 1 |
| Pisarski, W | 1 |
| Sasinowska, M | 1 |
| Smiałek, M | 1 |
| Johnson, WT | 1 |
| Bowers, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT00004325] | 200 participants | Observational | 1988-12-31 | Completed | |||
| The Effect of Vigabatrin on Cerebral Blood Flow and Glucose Metabolism[NCT00001489] | 20 participants | Observational | 1994-10-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for homovanillic acid and Epilepsy
| Article | Year |
|---|---|
Brain monoamines in seizure mechanism (review).
Topics: Animals; Brain; Carbonic Anhydrase Inhibitors; Catecholamines; Child; Dextroamphetamine; Dopamine; E | 1977 |
3 trials available for homovanillic acid and Epilepsy
| Article | Year |
|---|---|
Aspartame has no effect on seizures or epileptiform discharges in epileptic children.
Topics: Adolescent; Aspartame; Brain; Child; Child, Preschool; Dopamine; Double-Blind Method; Electroencepha | 1994 |
Manipulation of cerebral monoamines in the treatment of human epilepsy: a pilot study.
Topics: Adult; Biogenic Amines; Brain Chemistry; Carbamazepine; Drug Evaluation; Epilepsy; Homovanillic Acid | 1978 |
Serotonin and myoclonus.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Carbidopa; Clinical Trials as Topic; Epilepsy; Female; Homov | 1976 |
36 other studies available for homovanillic acid and Epilepsy
| Article | Year |
|---|---|
Secondary neurotransmitter deficiencies in epilepsy caused by voltage-gated sodium channelopathies: A potential treatment target?
Topics: Autistic Disorder; Channelopathies; Child; Drug Resistant Epilepsy; Epilepsy; Exome; Female; Homovan | 2016 |
Reversible parkinsonism following heroin pyrolysate inhalation is associated with tetrahydrobiopterin deficiency.
Topics: Adult; Biopterins; Brain; Brain Diseases, Metabolic; Electroencephalography; Epilepsy; Female; Heroi | 2004 |
Variations of dopamine, serotonin, and amino acid concentrations in Noda epileptic rat (NER) retina.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Amino Acids; Animals; Animals, Newborn; Biogenic Monoamines; | 2006 |
Secondary abnormalities of neurotransmitters in infants with neurological disorders.
Topics: 5-Hydroxytryptophan; Atrophy; Brain; Electroencephalography; Epilepsy; Female; Homovanillic Acid; Hu | 2007 |
A new fatal case of pyridox(am)ine 5'-phosphate oxidase (PNPO) deficiency.
Topics: Brain Diseases, Metabolic, Inborn; Codon, Nonsense; Epilepsy; Fatal Outcome; Genes, Recessive; Homov | 2008 |
Ontogeny of dopamine and serotonin metabolites in the cerebrospinal fluid of children with neurological disorders.
Topics: Adolescent; Child; Child, Preschool; Dopamine; Epilepsy; Female; Homovanillic Acid; Humans; Hydroxyi | 1980 |
Serotonergic and dopaminergic metabolites in cerebrospinal fluid of epileptics.
Topics: Adult; Dopamine; Epilepsy; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Serotonin | 1982 |
A study of urinary excretion of biogenic amine metabolites in epilepsy.
Topics: Adolescent; Adult; Biogenic Amines; Epilepsy; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic | 1983 |
Thyrotropin-releasing hormone in treatment of intractable epilepsy: neurochemical analysis of CSF monoamine metabolites.
Topics: Child; Child, Preschool; Electroencephalography; Epilepsy; Female; Homovanillic Acid; Humans; Hydrox | 1995 |
Retinal dopamine and its metabolite contents in zitter rats and spontaneously epileptic rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Dopamine; Epilepsy; Homovanillic Acid; Male; Rats; Rats, In | 1993 |
[Study on dopamine metabolite in cerebrospinal fluid of schizophrenics and epilepsics].
Topics: Adult; Dopamine; Epilepsy; Female; Homovanillic Acid; Humans; Male; Middle Aged; Schizophrenia | 1998 |
Monoamine metabolites in the CSF of epileptic patients.
Topics: Adolescent; Adult; Child; Epilepsy; Female; Glycols; Homovanillic Acid; Humans; Hydroxyindoleacetic | 1979 |
Amines, anticonvulsants, and epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Brain; Chromatography, Gas; Drug Therapy, Combination; Epilepsy; | 1975 |
[Cerebrospinal fluid monoamine metabolites and cyclic nucleotides in the patients with epilepsy (author's transl)].
Topics: Adolescent; Adult; Aged; Cyclic AMP; Cyclic GMP; Epilepsy; Female; Glycols; Homovanillic Acid; Human | 1979 |
[Determination of HVA and 5-HIAA in epileptic syndromes in basal conditions and after treatment with probenecid].
Topics: Adolescent; Adult; Anticonvulsants; Brain; Dopamine; Epilepsy; Homovanillic Acid; Humans; Hydroxyind | 1979 |
Homovanillic acid in human cerebrospinal fluid.--Its concentration gradient and reduced levels in patients with epilepsy.
Topics: Adult; Child; Child, Preschool; Epilepsy; Female; Homovanillic Acid; Humans; Infant; Male; Phenylace | 1978 |
Transient hyperkinesia after a single intravenous perfusion of diphenylhydantoin. Report of a case associated with nontoxic plasma levels of diphenylhydantoin.
Topics: Adolescent; Epilepsy; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Hyperkinesis; Infusions, | 1979 |
Effects of taurine on seizures and growth hormone release in epileptic patients.
Topics: Adolescent; Adult; Child; Epilepsy; Growth Hormone; Homovanillic Acid; Humans; Taurine | 1979 |
[Convulsions and monoamines].
Topics: Animals; Biogenic Amines; Brain Chemistry; Dopamine; Epilepsy; Homovanillic Acid; Mice; Rats; Reserp | 1978 |
[Biochemistry of epilepsy (author's transl)].
Topics: Animals; Biogenic Amines; Brain Chemistry; Catecholamines; Cats; Dopamine; Epilepsy; Guanidines; Hom | 1978 |
Reduced cerebrospinal fluid 5-hydroxyindoleacetic acid and homovanillic acid in children with epilepsy.
Topics: Acetazolamide; Adolescent; Age Factors; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy | 1975 |
[Homovanillic acid concentration of the cerebrospinal fluid in epilepsy].
Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Epilepsies, Partial; Epilepsy; Epilepsy, Ab | 1976 |
Serotonin metabolism in human epilepsy: the influence of anticonvulsant drugs.
Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; M | 1977 |
[Homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) levels in the lumbar cerebrospinal fluid in epileptic patients].
Topics: Adult; Epilepsy; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Phenylacetates; Spectrophotome | 1976 |
Folate and monoamine metabolism in epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Biogenic Amines; Epilepsy; Erythrocytes; Folic Acid; Homovanilli | 1975 |
Monoamine metabolites, iron induced seizures, and the anticonvulsant effect of tannins.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Anticonvulsants; Biogenic Monoamines; Brain; Catechin; Chlo | 1992 |
Anticonvulsant activity of di-n-propylacetate and brain monoamine metabolism in the rat.
Topics: Animals; Biogenic Monoamines; Brain; Catecholamines; Epilepsy; Female; gamma-Aminobutyric Acid; Homo | 1990 |
Effects of anticonvulsant treatment and low levels of folate and thiamine on amine metabolites in cerebrospinal fluid.
Topics: Adult; Biogenic Amines; Brain; Electroencephalography; Epilepsy; Female; Folic Acid; Homovanillic Ac | 1991 |
The acute convulsant effect of MPTP is dependent on intracerebral MPP+.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Chemist | 1991 |
Reduction of biogenic amine levels in the Rett syndrome.
Topics: Adolescent; Ataxia; Autistic Disorder; Biogenic Amines; Child; Child, Preschool; Dementia; Electroen | 1985 |
Cerebrospinal fluid amino acid and monoamine metabolite levels of Papio papio: correlation with photosensitivity.
Topics: Amino Acids; Animals; Biogenic Amines; Epilepsy; Female; gamma-Aminobutyric Acid; Homovanillic Acid; | 1986 |
The effect of different vigabatrin treatment regimens on CSF biochemistry and seizure control in epileptic patients.
Topics: Adult; Aminocaproates; Anticonvulsants; Carnosine; Cerebrospinal Fluid Proteins; Epilepsy; Female; g | 1989 |
A study of monoamine metabolism in human epilepsy.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Epilepsy; Female; Hippocampus; Homovanillic Acid; Humans; Hyd | 1989 |
Analysis of monamine metabolism in cerebrospinal fluid in childhood epilepsies.
Topics: Adolescent; Brain Damage, Chronic; Child; Child, Preschool; Epilepsies, Myoclonic; Epilepsy; Epileps | 1989 |
[Gamma-aminobutyric acid (GABA) and homovanillic acid (HVA) levels in the cerebrospinal fluid of patients with epilepsy].
Topics: Adolescent; Adult; Age Factors; Aged; Epilepsy; Female; gamma-Aminobutyric Acid; Homovanillic Acid; | 1985 |
Biogenic amines in autistic and atypical children. Cerebrospinal fluid measures of homovanillic acid and 5-hydroxyindoleacetic acid.
Topics: Autistic Disorder; Brain; Child; Child, Preschool; Diagnosis, Differential; Dopamine; Electroencepha | 1974 |