homovanillic acid has been researched along with Dystonia in 31 studies
Homovanillic Acid: A 3-O-methyl ETHER of (3,4-dihydroxyphenyl)acetic acid.
homovanillate : A hydroxy monocarboxylic acid anion which is obtained by deprotonation of the carboxy group of homovanillic acid.
homovanillic acid : A monocarboxylic acid that is the 3-O-methyl ether of (3,4-dihydroxyphenyl)acetic acid. It is a catecholamine metabolite.
Dystonia: An attitude or posture due to the co-contraction of agonists and antagonist muscles in one region of the body. It most often affects the large axial muscles of the trunk and limb girdles. Conditions which feature persistent or recurrent episodes of dystonia as a primary manifestation of disease are referred to as DYSTONIC DISORDERS. (Adams et al., Principles of Neurology, 6th ed, p77)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Rapid-onset dystonia-parkinsonism (RDP) is characterized by sudden onset over hours to days of dystonia, dysphagia, dysarthria, and parkinsonism." | 5.30 | Cerebrospinal fluid homovanillic acid levels in rapid-onset dystonia-parkinsonism. ( Brashear, A; Butler, IJ; Dobyns, WB; Farlow, MR; Hyland, K, 1998) |
| "Rapid-onset dystonia-parkinsonism (RDP) is a genetic movement disorder characterized by abrupt onset over hours to days of bradykinesia, postural instability, dysphagia, dysarthria, and severe dystonic spasms with decreased levels of the dopamine metabolite, homovanillic acid (HVA), in cerebrospinal fluid (CSF)." | 3.70 | PET imaging of the pre-synaptic dopamine uptake sites in rapid-onset dystonia-parkinsonism (RDP). ( Brashear, A; Farlow, MR; Hutchins, GD; Mulholland, GK; Siemers, ER; Zheng, QH, 1999) |
| "We report a family with autosomal dominant type hereditary juvenile dystonia-parkinsonism in which eight members in three generations exhibited parkinsonism, sleep benefit, marked efficacy of levodopa, wearing-off phenomenon, and dopa-induced choreic dyskinesia." | 3.69 | A family with hereditary juvenile dystonia-parkinsonism. ( Ishikawa, A; Miyatake, T, 1995) |
| "Two cases of severe dystonia and dyskinesia were treated with talipexole, a dopamine autoreceptor agonist, and the metabolites of dopamine, norepinephrine, and serotonin in cerebrospinal fluid (CSF) were determined." | 3.68 | Chronic treatment with talipexole dihydrochloride on abnormal involuntary movement in humans. ( Koga, I; Nishikawa, T; Tanaka, M; Tsuda, A; Uchida, Y; Yamada, S, 1990) |
| "Two pairs of siblings with severe dystonia with marked diurnal fluctuation had both reduced CSF concentration of biopterin and marked symptomatic improvement of the dystonia in response to levodopa." | 3.67 | Dystonia with marked diurnal variation associated with biopterin deficiency. ( Barton, N; Burns, RS; Cohen, W; Fink, JK; Hallett, M; Lovenberg, W, 1988) |
| "Homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA), the respective metabolites of dopamine and serotonin, were measured in ventricular fluid obtained from 20 patients with torsion dystonia at the time of ventriculography prior to thalamic surgery." | 3.66 | Diminished ventricular fluid dopamine metabolites in adult-onset dystonia. ( Sharpless, NS; Tabaddor, K; Wolfson, LI, 1978) |
| "Treatment with levodopa gives remarkable and durable results, but it must be continued indefinitely." | 2.38 | [Dopa-sensitive dystonia]. ( Aicardi, J; Goutières, F; Rondot, P; Ziegler, M, 1992) |
| "Mitochondrial disorders are clinically heterogeneous." | 1.35 | Mitochondrial diseases mimicking neurotransmitter defects. ( Artuch, R; Briones, P; Carrilho, I; Duarte, S; Garcia-Cazorla, A; Garesse, R; Montoya, J; Nascimento, A; Ormazabal, A; Pineda, M; Sala-Castellvi, P; Serrano, M, 2008) |
| "The typical infantile form of dystonia is benign, resolving by 2 years of age in an otherwise normal child." | 1.31 | Infantile-onset paroxysmal dystonia: a diagnostic dilemma. ( Antony, J; Howman-Giles, R; Wilmshurst, JM, 2001) |
| "Childhood dystonia that does not respond to treatment with levodopa (dopa-nonresponsive dystonia, DND) has an unclear pathogenesis and is notoriously difficult to treat." | 1.31 | Selective decrease in central nervous system serotonin turnover in children with dopa-nonresponsive dystonia. ( Assmann, B; Heales, S; Hoffmann, GF; Köhler, M; Surtees, R, 2002) |
| "Rapid-onset dystonia-parkinsonism (RDP) is characterized by sudden onset over hours to days of dystonia, dysphagia, dysarthria, and parkinsonism." | 1.30 | Cerebrospinal fluid homovanillic acid levels in rapid-onset dystonia-parkinsonism. ( Brashear, A; Butler, IJ; Dobyns, WB; Farlow, MR; Hyland, K, 1998) |
| "The diagnosis of dopa-responsive dystonia should be considered in children with unexplained or atypical "cerebral palsy." | 1.29 | Dopa-responsive dystonia simulating cerebral palsy. ( Chutorian, AM; Levine, RA; Naini, AB; Nygaard, TG; Waran, SP, 1994) |
| "She had onset of foot dystonia at age 5 years and by age 8 years it was generalized with prominent right leg and arm involvement." | 1.29 | Dopa-responsive dystonia: pathological and biochemical observations in a case. ( Chang, LG; Gibb, WR; Hornykiewicz, O; Kish, S; Rajput, AH; Shannak, KS; Zhong, XH, 1994) |
| "Rapid-onset dystonia-parkinsonism (RDP) is an autosomal dominant disorder characterized by the rapid onset of dystonic spasms and parkinsonism over a period of a few hours to weeks after their onset." | 1.29 | Variable phenotype of rapid-onset dystonia-parkinsonism. ( Brashear, A; Butler, IJ; Dobyns, WB; Farlow, MR; Kasarskis, EJ, 1996) |
| "HVA levels in dystonia patients (30." | 1.29 | Neurotransmitters in CSF of idiopathic adult-onset dystonia: reduced 5-HIAA levels as evidence of impaired serotonergic metabolism. ( Götz, M; Lange, KW; Naumann, M; Reiners, K; Riederer, P, 1996) |
| "We describe two sporadic cases of dystonia-parkinsonism at different stages of disease progression." | 1.28 | Consideration on two cases of dystonia-parkinsonism. ( Balottin, U; Borgatti, R; Lanzi, G; Zambrino, CA, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (32.26) | 18.7374 |
| 1990's | 12 (38.71) | 18.2507 |
| 2000's | 6 (19.35) | 29.6817 |
| 2010's | 3 (9.68) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Garcia-Cazorla, A | 1 |
| Duarte, S | 1 |
| Serrano, M | 1 |
| Nascimento, A | 1 |
| Ormazabal, A | 1 |
| Carrilho, I | 1 |
| Briones, P | 1 |
| Montoya, J | 1 |
| Garesse, R | 1 |
| Sala-Castellvi, P | 1 |
| Pineda, M | 1 |
| Artuch, R | 1 |
| Mak, CM | 1 |
| Lam, CW | 1 |
| Siu, TS | 1 |
| Chan, KY | 1 |
| Siu, WK | 1 |
| Yeung, WL | 1 |
| Hui, J | 1 |
| Wong, VC | 1 |
| Low, LC | 1 |
| Ko, CH | 1 |
| Fung, CW | 1 |
| Chen, SP | 1 |
| Yuen, YP | 1 |
| Lee, HC | 1 |
| Yau, E | 1 |
| Chan, B | 1 |
| Tong, SF | 1 |
| Tam, S | 1 |
| Chan, YW | 1 |
| Kurian, MA | 1 |
| Li, Y | 2 |
| Zhen, J | 1 |
| Meyer, E | 1 |
| Hai, N | 1 |
| Christen, HJ | 1 |
| Hoffmann, GF | 2 |
| Jardine, P | 1 |
| von Moers, A | 1 |
| Mordekar, SR | 1 |
| O'Callaghan, F | 1 |
| Wassmer, E | 1 |
| Wraige, E | 1 |
| Dietrich, C | 1 |
| Lewis, T | 1 |
| Hyland, K | 2 |
| Heales, S | 2 |
| Sanger, T | 1 |
| Gissen, P | 1 |
| Assmann, BE | 1 |
| Reith, ME | 1 |
| Maher, ER | 1 |
| Giovanniello, T | 1 |
| Claps, D | 1 |
| Carducci, C | 2 |
| Blau, N | 1 |
| Vigevano, F | 1 |
| Antonozzi, I | 1 |
| Leuzzi, V | 1 |
| Barnett, MH | 1 |
| Jarman, PR | 1 |
| Heales, SJ | 1 |
| Bhatia, KP | 1 |
| Augood, SJ | 1 |
| Hollingsworth, Z | 1 |
| Albers, DS | 1 |
| Yang, L | 1 |
| Leung, J | 1 |
| Breakefield, XO | 2 |
| Standaert, DG | 1 |
| Dang, MT | 1 |
| Yokoi, F | 1 |
| McNaught, KS | 1 |
| Jengelley, TA | 1 |
| Jackson, T | 1 |
| Li, J | 1 |
| Willemse, J | 1 |
| van Nieuwenhuizen, O | 1 |
| Gooskens, RH | 1 |
| Westenberg, HG | 1 |
| Ishikawa, A | 1 |
| Miyatake, T | 1 |
| Nygaard, TG | 2 |
| Waran, SP | 1 |
| Levine, RA | 4 |
| Naini, AB | 1 |
| Chutorian, AM | 1 |
| Rajput, AH | 1 |
| Gibb, WR | 1 |
| Zhong, XH | 1 |
| Shannak, KS | 1 |
| Kish, S | 1 |
| Chang, LG | 1 |
| Hornykiewicz, O | 1 |
| Takahashi, H | 1 |
| Galloway, MP | 1 |
| Snow, BJ | 1 |
| Calne, DB | 1 |
| Brashear, A | 4 |
| Farlow, MR | 4 |
| Butler, IJ | 3 |
| Kasarskis, EJ | 1 |
| Dobyns, WB | 3 |
| Naumann, M | 1 |
| Götz, M | 1 |
| Reiners, K | 1 |
| Lange, KW | 1 |
| Riederer, P | 1 |
| Ozelius, LJ | 1 |
| Kramer, PI | 1 |
| Mulholland, GK | 1 |
| Zheng, QH | 1 |
| Siemers, ER | 1 |
| Hutchins, GD | 1 |
| Wilmshurst, JM | 1 |
| Howman-Giles, R | 1 |
| Antony, J | 1 |
| Assmann, B | 1 |
| Köhler, M | 1 |
| Surtees, R | 1 |
| Meltzer, HY | 1 |
| Young, M | 1 |
| Metz, J | 1 |
| Fang, VS | 1 |
| Schyve, PM | 1 |
| Arora, RC | 1 |
| Tabaddor, K | 1 |
| Wolfson, LI | 2 |
| Sharpless, NS | 2 |
| Ouvrier, RA | 1 |
| Rondot, P | 1 |
| Aicardi, J | 1 |
| Goutières, F | 1 |
| Ziegler, M | 1 |
| Nishikawa, T | 1 |
| Yamada, S | 1 |
| Tsuda, A | 1 |
| Tanaka, M | 1 |
| Koga, I | 1 |
| Uchida, Y | 1 |
| Zambrino, CA | 1 |
| Balottin, U | 1 |
| Borgatti, R | 1 |
| Lanzi, G | 1 |
| Fink, JK | 2 |
| Barton, N | 1 |
| Cohen, W | 1 |
| Lovenberg, W | 2 |
| Burns, RS | 2 |
| Hallett, M | 2 |
| Thal, LJ | 1 |
| LeWitt, PA | 1 |
| Miller, LP | 1 |
| Newman, RP | 1 |
| Papavasiliou, A | 1 |
| Rayes, A | 1 |
| Eldridge, R | 1 |
| Maekawa, N | 1 |
| Hashimoto, T | 1 |
| Sasaki, M | 1 |
| Oishi, T | 1 |
| Tsuji, S | 1 |
| Ravin, P | 1 |
| Argoff, CE | 1 |
| Brady, RO | 1 |
| Barton, NW | 1 |
| Stahl, SM | 1 |
| Faull, KF | 1 |
| Barchas, JD | 1 |
| Berger, PA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Cerebral Autoregulation in Patients With Aneurysmal SubArachnoid Haemorrhage[NCT03987139] | 45 participants (Anticipated) | Interventional | 2019-06-15 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for homovanillic acid and Dystonia
| Article | Year |
|---|---|
[Dopa-sensitive dystonia].
Topics: Carbidopa; Child; Child, Preschool; Dystonia; Female; Follow-Up Studies; Homovanillic Acid; Humans; | 1992 |
30 other studies available for homovanillic acid and Dystonia
| Article | Year |
|---|---|
Mitochondrial diseases mimicking neurotransmitter defects.
Topics: Alanine; Brain; Child, Preschool; Consanguinity; Diagnosis, Differential; Dopamine Agents; Dystonia; | 2008 |
Biochemical and molecular characterization of tyrosine hydroxylase deficiency in Hong Kong Chinese.
Topics: Age of Onset; Asian People; Child; Child, Preschool; Dystonia; Female; Galactorrhea; Homovanillic Ac | 2010 |
Clinical and molecular characterisation of hereditary dopamine transporter deficiency syndrome: an observational cohort and experimental study.
Topics: Brain; Cell Line, Transformed; Child; Child, Preschool; Cohort Studies; Dopamine Plasma Membrane Tra | 2011 |
A new tyrosine hydroxylase genotype associated with early-onset severe encephalopathy.
Topics: Child, Preschool; Dystonia; Genetic Testing; Homovanillic Acid; Humans; Male; Mutation, Missense; Pr | 2012 |
Further case of paroxysmal exercise-induced dystonia and some insights into pathogenesis.
Topics: Adult; Dopamine; Dystonia; Exercise; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; Neur | 2002 |
Dopamine transmission in DYT1 dystonia.
Topics: 3,4-Dihydroxyphenylacetic Acid; Autoradiography; Basal Ganglia; Benzamides; Benzazepines; Binding Si | 2004 |
Generation and characterization of Dyt1 DeltaGAG knock-in mouse as a model for early-onset dystonia.
Topics: 3,4-Dihydroxyphenylacetic Acid; Age of Onset; Animals; Brain; Chromatography, High Pressure Liquid; | 2005 |
Treatment of non-fluctuating progressive dystonia: a neuropharmacological approach.
Topics: Adolescent; Basal Ganglia; Child; Chromatography, High Pressure Liquid; Dystonia; Female; Homovanill | 1984 |
A family with hereditary juvenile dystonia-parkinsonism.
Topics: Adult; Aged; Antiparkinson Agents; Chromosome Aberrations; Chromosome Disorders; Dystonia; Female; F | 1995 |
Dopa-responsive dystonia simulating cerebral palsy.
Topics: Adolescent; Adult; Biopterins; Carbidopa; Cerebral Palsy; Child; Diagnosis, Differential; Dose-Respo | 1994 |
Dopa-responsive dystonia: pathological and biochemical observations in a case.
Topics: Adult; Brain; Child; Dopamine; Dystonia; Female; Homovanillic Acid; Humans; Levodopa; Radioligand As | 1994 |
Biochemical and fluorodopa positron emission tomographic findings in an asymptomatic carrier of the gene for dopa-responsive dystonia.
Topics: Adolescent; Adult; Aged; Biopterins; Dystonia; Female; Fluorine Radioisotopes; Heterozygote; Homovan | 1994 |
Variable phenotype of rapid-onset dystonia-parkinsonism.
Topics: Adolescent; Adult; Dopamine; Dystonia; Female; Follow-Up Studies; Genetic Carrier Screening; Homovan | 1996 |
Neurotransmitters in CSF of idiopathic adult-onset dystonia: reduced 5-HIAA levels as evidence of impaired serotonergic metabolism.
Topics: Adult; Age of Onset; Aged; Aged, 80 and over; Case-Control Studies; Dopamine; Dystonia; Female; Homo | 1996 |
Cerebrospinal fluid homovanillic acid levels in rapid-onset dystonia-parkinsonism.
Topics: Adult; Aged; Antiparkinson Agents; Biomarkers; Deglutition Disorders; Dopamine; Dysarthria; Dystonia | 1998 |
Rapid-onset dystonia-parkinsonism: a report of clinical, biochemical, and genetic studies in two families.
Topics: Adolescent; Adult; Age of Onset; Diagnosis, Differential; Disease Progression; Dystonia; Family Heal | 1998 |
PET imaging of the pre-synaptic dopamine uptake sites in rapid-onset dystonia-parkinsonism (RDP).
Topics: Adult; Aged; Brain Mapping; Carbon Radioisotopes; Cocaine; Corpus Striatum; Diagnosis, Differential; | 1999 |
Infantile-onset paroxysmal dystonia: a diagnostic dilemma.
Topics: Brain; Consanguinity; Dominance, Cerebral; Dystonia; Homovanillic Acid; Humans; Hydroxyindoleacetic | 2001 |
Selective decrease in central nervous system serotonin turnover in children with dopa-nonresponsive dystonia.
Topics: Adolescent; Central Nervous System; Child; Child, Preschool; Dihydroxyphenylalanine; Dopamine Agents | 2002 |
Extrapyramidal side effects and increased serum prolactin following fluoxetine, a new antidepressant.
Topics: Adult; Antidepressive Agents; Blood Platelets; Depression; Dystonia; Extrapyramidal Tracts; Female; | 1979 |
Diminished ventricular fluid dopamine metabolites in adult-onset dystonia.
Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Dystonia; Female; Homovanillic Acid; Humans | 1978 |
Progressive dystonia with marked diurnal fluctuation.
Topics: Child; Circadian Rhythm; Diagnosis, Differential; Dystonia; Female; Homovanillic Acid; Humans; Hydro | 1978 |
Chronic treatment with talipexole dihydrochloride on abnormal involuntary movement in humans.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aged; Azepines; Dopamine Agents; Dystonia; Homovanillic Acid; Humans | 1990 |
Consideration on two cases of dystonia-parkinsonism.
Topics: Carbidopa; Child; Dystonia; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Levodopa; M | 1991 |
Dystonia with marked diurnal variation associated with biopterin deficiency.
Topics: Adolescent; Adult; Biopterins; Carbidopa; Child; Child, Preschool; Circadian Rhythm; Drug Combinatio | 1988 |
Diminished levels of ventricular fluid norepinephrine metabolite and somatostatin in childhood-onset dystonia.
Topics: Adolescent; Adult; Age Factors; Cerebral Palsy; Child; Child, Preschool; Dystonia; Homovanillic Acid | 1988 |
Pterin abnormalities in dystonia: a metabolic marker with therapeutic implications.
Topics: Adult; Biopterins; Central Nervous System; Dystonia; Homovanillic Acid; Humans; Hydroxyindoleacetic | 1988 |
[A study on catecholamine metabolites in CSF in a patient with progressive dystonia with marked diurnal fluctuation].
Topics: Adolescent; Catecholamines; Circadian Rhythm; Dystonia; Female; Homovanillic Acid; Humans; Hydroxyin | 1988 |
Tetrahydrobiopterin administration in biopterin-deficient progressive dystonia with diurnal variation.
Topics: Adult; Biopterins; Child; Circadian Rhythm; Dystonia; Female; Homovanillic Acid; Humans; Hydroxyindo | 1989 |
CSF monamine metabolites in movement disorders and normal aging.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Aged; Dyskinesia, Drug-Induced; Dystonia; Female; Glycols; Ho | 1985 |