homovanillic acid and Down Syndrome
homovanillic acid has been researched along with Down Syndrome in 9 studies
Homovanillic Acid: A 3-O-methyl ETHER of (3,4-dihydroxyphenyl)acetic acid.
homovanillate : A hydroxy monocarboxylic acid anion which is obtained by deprotonation of the carboxy group of homovanillic acid.
homovanillic acid : A monocarboxylic acid that is the 3-O-methyl ether of (3,4-dihydroxyphenyl)acetic acid. It is a catecholamine metabolite.
Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Noradrenaline, dopamine, homovanillic acid (HVA), choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) levels were measured in post-mortem brains from 8 cases of pre-senile Alzheimer-type dementia (ATD), 5 cases of senile ATD, 4 cases of Down's syndrome aged 53-57 years, one 27-year-old case of Down's syndrome and 13 controls." | 3.66 | Catecholamines and cholinergic enzymes in pre-senile and senile Alzheimer-type dementia and Down's syndrome. ( Allison, Y; Gordon, A; Maloney, AF; Ritchie, IM; Simpson, J; Urquhart, A; Yates, CM, 1983) |
Research
Studies (9)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (77.78) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Coppus, AW | 1 |
| Fekkes, D | 1 |
| Verhoeven, WM | 1 |
| Tuinier, S | 1 |
| Egger, JI | 1 |
| van Duijn, CM | 1 |
| Yates, CM | 1 |
| Simpson, J | 1 |
| Gordon, A | 1 |
| Maloney, AF | 1 |
| Allison, Y | 1 |
| Ritchie, IM | 1 |
| Urquhart, A | 1 |
| Komatsu, H | 1 |
| Nishimura, A | 1 |
| Okano, S | 1 |
| Miyanomae, Y | 1 |
| Takeuchi, Y | 1 |
| Sawada, T | 1 |
| Kay, AD | 2 |
| Schapiro, MB | 2 |
| Riker, AK | 1 |
| Haxby, JV | 2 |
| Rapoport, SI | 2 |
| Cutler, NR | 1 |
| Godridge, H | 1 |
| Reynolds, GP | 1 |
| Czudek, C | 1 |
| Calcutt, NA | 1 |
| Benton, M | 1 |
| May, C | 1 |
| Ryker, AK | 1 |
| Kaufman, S | 1 |
| Milstien, S | 1 |
| Chase, TN | 2 |
| Gordon, EK | 1 |
| Ng, LK | 1 |
| Burger, PC | 1 |
| Vogel, FS | 1 |
Reviews
1 review available for homovanillic acid and Down Syndrome
| Article | Year |
|---|---|
Serotonergic mechanisms and extrapyramidal function in man.
Topics: 5-Hydroxytryptophan; Carbidopa; Cerebellar Diseases; Creutzfeldt-Jakob Syndrome; Down Syndrome; Extr | 1974 |
Other Studies
8 other studies available for homovanillic acid and Down Syndrome
| Article | Year |
|---|---|
Plasma amino acids and neopterin in healthy persons with Down's syndrome.
Topics: Aged; Amino Acid Metabolism, Inborn Errors; Amino Acids; Biomarkers; Comorbidity; Dopamine; Down Syn | 2007 |
Catecholamines and cholinergic enzymes in pre-senile and senile Alzheimer-type dementia and Down's syndrome.
Topics: Acetylcholinesterase; Adult; Aged; Aging; Alzheimer Disease; Brain; Choline O-Acetyltransferase; Dem | 1983 |
Neuroleptic malignant syndrome-like state in a patient with Down syndrome and basal ganglia calcification.
Topics: Adolescent; Basal Ganglia Diseases; Calcinosis; Down Syndrome; Homovanillic Acid; Humans; Hydroxyind | 1992 |
Cerebrospinal fluid monoaminergic metabolites are elevated in adults with Down's syndrome.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Catecholamines; Down Syndrome; Female; Homovanillic Aci | 1987 |
Alzheimer-like neurotransmitter deficits in adult Down's syndrome brain tissue.
Topics: Acetylcholine; Adult; Age Factors; Alzheimer Disease; Brain; Choline O-Acetyltransferase; Dopamine; | 1987 |
Cerebrospinal fluid monoamines in Down's syndrome adults at different ages.
Topics: Adult; Age Factors; Amines; Biopterins; Catecholamines; Cognition; Dementia; Down Syndrome; Female; | 1987 |
Norepinephrine metabolism in the central nervous system of man: studies using 3-methoxy-4-hydroxyphenylethylene glycol levels in cerebrospinal fluid.
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Carbon Radioisotopes; Cerebrospinal Fluid; Child; | 1973 |
The development of the pathologic changes of Alzheimer's disease and senile dementia in patients with Down's syndrome.
Topics: Adolescent; Adult; Aged; Autopsy; Brain; Brain Chemistry; Child; Child, Preschool; Dementia; Down Sy | 1973 |