Page last updated: 2024-10-21

homovanillic acid and Delayed Effects, Prenatal Exposure

homovanillic acid has been researched along with Delayed Effects, Prenatal Exposure in 31 studies

Homovanillic Acid: A 3-O-methyl ETHER of (3,4-dihydroxyphenyl)acetic acid.
homovanillate : A hydroxy monocarboxylic acid anion which is obtained by deprotonation of the carboxy group of homovanillic acid.
homovanillic acid : A monocarboxylic acid that is the 3-O-methyl ether of (3,4-dihydroxyphenyl)acetic acid. It is a catecholamine metabolite.

Research Excerpts

ExcerptRelevanceReference
" In addition, the exposure to new environmental condition elevated blood corticosterone levels and enhanced behavioral activities to a greater extent in the Dex group than in controls at 7 wk of life, suggesting that elevated glucocorticoid levels during the pregnancy mimicked prenatal mild stress, producing developmental alterations in brain monoamine metabolism, endocrine response, and behavior in adult offspring."3.69Prenatal dexamethasone exposure alters brain monoamine metabolism and adrenocortical response in rat offspring. ( Kamei, K; Kitera, K; Mikuni, M; Muneoka, K; Ogawa, T; Takahashi, K; Takigawa, M, 1997)
"Schizophrenia is probably ascribed to perinatal neurodevelopmental deficits, and its onset might be affected by environmental factors."1.62Preventive role of regular low-intensity exercise during adolescence in schizophrenia model mice with abnormal behaviors. ( Hata, T; Hiraga, T; Koizumi, H; Mouri, A; Nabeshima, T; Oharomari, LK; Okamoto, M; Shima, T; Soya, H; Yook, JS, 2021)
"Idiopathic Parkinson's disease (PD) is a neurodegenerative disorder of mature and older individuals."1.36Modeling a sensitization stage and a precipitation stage for Parkinson's disease using prenatal and postnatal 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration. ( Charlton, CG; King, J; Mackey, V; Muthian, G, 2010)
" Acute or chronic administration of methamphetamine elevates the levels of the extracellular monoamine neurotransmitters, such as dopamine."1.35Prenatal methamphetamine exposure affects the mesolimbic dopaminergic system and behavior in adult offspring. ( Bubenikova-Valesova, V; Hruba, L; Janovsky, M; Kacer, P; Rambousek, L; Schutova, B; Slamberova, R; Syslova, K, 2009)
"Styrene was evaluated to determine its neurochemical effects in the offspring of rats exposed during the gestation period."1.30Effects of prenatal exposure to styrene on neurochemical levels in rat brain. ( Ikeda, T; Katakura, Y; Kishi, R; Miyake, H, 1999)

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-19902 (6.45)18.7374
1990's11 (35.48)18.2507
2000's13 (41.94)29.6817
2010's4 (12.90)24.3611
2020's1 (3.23)2.80

Authors

AuthorsStudies
Koizumi, H1
Hiraga, T1
Oharomari, LK1
Hata, T1
Shima, T1
Yook, JS1
Okamoto, M1
Mouri, A1
Nabeshima, T1
Soya, H1
Rose, KM1
Parmar, MS1
Cavanaugh, JE1
Winter, C1
Djodari-Irani, A1
Sohr, R1
Morgenstern, R1
Feldon, J1
Juckel, G1
Meyer, U1
Yokota, S1
Mizuo, K1
Moriya, N1
Oshio, S1
Sugawara, I1
Takeda, K1
Tekes, K1
Gyenge, M1
Hantos, M1
Csaba, G1
Ling, Z2
Zhu, Y1
Tong, CW1
Snyder, JA1
Lipton, JW1
Carvey, PM2
Wang, S1
Yan, JY1
Lo, YK1
Bubenikova-Valesova, V1
Kacer, P1
Syslova, K1
Rambousek, L1
Janovsky, M1
Schutova, B1
Hruba, L1
Slamberova, R1
Muthian, G1
Mackey, V1
King, J1
Charlton, CG1
Hamilton, LR1
Czoty, PW1
Nader, MA1
Phillips, PE1
Johns, JM1
Lubin, DA1
Budygin, EA1
Gainetdinov, RR1
Lieberman, JA1
Wightman, RM1
Galineau, L1
Belzung, C1
Kodas, E1
Bodard, S1
Guilloteau, D1
Chalon, S1
Aldridge, JE1
Meyer, A1
Seidler, FJ2
Slotkin, TA2
Kreider, ML1
Tate, CA1
Yim, AJ1
Miranda-Paiva, CM1
Flório, JC1
Oliveira, CA1
Nasello, AG1
Felicio, LF1
Wang, CT1
Shui, HA1
Huang, RL1
Tai, MY1
Peng, MT1
Tsai, YF1
Romero, E1
Guaza, C1
Castellano, B1
Borrell, J1
Pérez-Otaño, I2
Luquin, MR2
Oset, C2
Herrero, MT1
Kupsch, A2
Oertel, W2
Obeso, JA2
Del Río, J2
Alonso, SJ1
Navarro, E1
Rodriguez, M1
Needlman, R1
Zuckerman, B1
Anderson, GM1
Mirochnick, M1
Cohen, DJ1
Silva-Araújo, A1
Silva, MC1
Simon, A1
Nguyen-Legros, J1
Ali, SF1
Tavares, MA1
Muneoka, K1
Mikuni, M1
Ogawa, T1
Kitera, K1
Kamei, K1
Takigawa, M1
Takahashi, K1
Watanabe, M1
Nonaka, R1
Hagino, Y1
Kodama, Y1
Schneider, ML1
Clarke, AS1
Kraemer, GW1
Roughton, EC1
Lubach, GR1
Rimm-Kaufman, S1
Schmidt, D1
Ebert, M1
Katakura, Y1
Kishi, R1
Ikeda, T1
Miyake, H1
Du, W1
Aloyo, VJ1
Pazdelski, PS1
Harvey, JA1
Won, L1
Bubula, N1
Heller, A1
Trinidad Herrero, M1
Chiavegatto, S1
Bernardi, MM1
Rathbun, W1
Druse, MJ1
Guilarte, TR1
Wagner, HN1
Frost, JJ1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized Controlled Trial of Adjunctive Siltuximab in Schizophrenia[NCT02796859]Phase 1/Phase 230 participants (Anticipated)Interventional2016-05-31Recruiting
An Open-Label Trial of Tocilizumab in Schizophrenia[NCT01696929]Phase 18 participants (Actual)Interventional2012-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Cognition

The Brief Assessment of Cognition in Schizophrenia (BACS) is the metric used to characterize cognition in this study. The BACS consists of 6 subscales: Verbal Memory (range 0-75), Working Memory (range 0-28), Motor Speed (range 0-100), Verbal Fluency (measure is total number of words generated in two 60 second trials), Attention and Processing speed (range 0-110), and Executive Function (range 0-22). For each subscale, higher scores reflect better cognition. For each subscale, a Standard Deviation Score was calculated based on normative data (Keefe et al. Norms and standardization of the Brief Assessment of Cognition in Schizophrenia (BACS). Schizophrenia Research 102 (2008) 108-115). The BACS composite score is calculated as the average Standard Deviation Score of the 6 subscale scores. The change in BACS composite score was calculated as the BACS composite score at 8 weeks minus the BACS composite score at baseline. (NCT01696929)
Timeframe: Change in BACS composite score from baseline to 8 weeks

InterventionChange in BACS Composite Score (Mean)
Tocilizumab0.7

Change in Total Psychotic Symptoms

The Positive and Negative Symptoms Scale (PANSS) is the metric used to characterize psychotic symptoms in this study. The PANSS consists of 30 items, each scored 1-7. The range for the PANSS total score is 30-210. There are 3 subscales - PANSS positive score (range 7-49), PANSS negative score (range 7-49), and PANSS general score (range 16-112). PANSS total score is the summation of these 3 subscales. Higher values for the total and subscale scores reflect more severe psychopathology. A positive change in PANSS total score reflects an increase in psychopathology. A negative change in PANSS total score reflects a decrease in psychopathology. (NCT01696929)
Timeframe: Change in PANSS total score from baseline to 8 weeks

InterventionChange in PANSS Total Score (Mean)
Tocilizumab-2.6

Other Studies

31 other studies available for homovanillic acid and Delayed Effects, Prenatal Exposure

ArticleYear
Preventive role of regular low-intensity exercise during adolescence in schizophrenia model mice with abnormal behaviors.
    Biochemical and biophysical research communications, 2021, 01-01, Volume: 534

    Topics: 3,4-Dihydroxyphenylacetic Acid; Age Factors; Animals; Behavior, Animal; Disease Models, Animal; Dopa

2021
Dietary supplementation with resveratrol protects against striatal dopaminergic deficits produced by in utero LPS exposure.
    Brain research, 2014, Jul-21, Volume: 1573

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dietary Supplements; Disease Models, Anima

2014
Prenatal immune activation leads to multiple changes in basal neurotransmitter levels in the adult brain: implications for brain disorders of neurodevelopmental origin such as schizophrenia.
    The international journal of neuropsychopharmacology, 2009, Volume: 12, Issue:4

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Chemistry; Brain Diseases; Chromatography, High Press

2009
Effect of prenatal exposure to diesel exhaust on dopaminergic system in mice.
    Neuroscience letters, 2009, Jan-02, Volume: 449, Issue:1

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Circadian Rhythm; Dopamine; Female; Homovanillic Aci

2009
Transgenerational hormonal imprinting caused by vitamin A and vitamin D treatment of newborn rats. Alterations in the biogenic amine contents of the adult brain.
    Brain & development, 2009, Volume: 31, Issue:9

    Topics: Animals; Animals, Newborn; Brain Chemistry; Dopamine; Female; Homovanillic Acid; Hydroxyindoleacetic

2009
Prenatal lipopolysaccharide does not accelerate progressive dopamine neuron loss in the rat as a result of normal aging.
    Experimental neurology, 2009, Volume: 216, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Age Factors; Aging; Analysis of Variance; Animals; Body Weight; Brai

2009
Dopaminergic and serotoninergic deficiencies in young adult rats prenatally exposed to the bacterial lipopolysaccharide.
    Brain research, 2009, Apr-10, Volume: 1265

    Topics: Amygdala; Animals; Brain; Corpus Striatum; Dopamine; Female; Frontal Lobe; Hippocampus; Homovanillic

2009
Prenatal methamphetamine exposure affects the mesolimbic dopaminergic system and behavior in adult offspring.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2009, Volume: 27, Issue:6

    Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic Uptake Inhibitors; Animals; Behavior, Animal; Disease Mod

2009
Modeling a sensitization stage and a precipitation stage for Parkinson's disease using prenatal and postnatal 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration.
    Neuroscience, 2010, Sep-01, Volume: 169, Issue:3

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Birth

2010
Behavioral characterization of adult male and female rhesus monkeys exposed to cocaine throughout gestation.
    Psychopharmacology, 2011, Volume: 213, Issue:4

    Topics: Animals; Behavior, Animal; Cocaine; Conditioning, Psychological; Female; Homovanillic Acid; Hydroxyi

2011
Presynaptic dopaminergic function is largely unaltered in mesolimbic and mesostriatal terminals of adult rats that were prenatally exposed to cocaine.
    Brain research, 2003, Jan-24, Volume: 961, Issue:1

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Autoreceptors; Cocaine; Corpus Striatum; Dopamine; Dopamine

2003
Prenatal 3,4-methylenedioxymethamphetamine (ecstasy) exposure induces long-term alterations in the dopaminergic and serotonergic functions in the rat.
    Brain research. Developmental brain research, 2005, Feb-08, Volume: 154, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; 3,4-Methylenedioxyamphetamine; Adrenergic Uptake Inhibitors; Age Fac

2005
Alterations in central nervous system serotonergic and dopaminergic synaptic activity in adulthood after prenatal or neonatal chlorpyrifos exposure.
    Environmental health perspectives, 2005, Volume: 113, Issue:8

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Animals, Newborn; Brain; Chlorpyrifos; Dopamine; Female; Ho

2005
Critical prenatal and postnatal periods for persistent effects of dexamethasone on serotonergic and dopaminergic systems.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2006, Volume: 31, Issue:5

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Developmental Disabilities; Dexamethasone; Dopamine;

2006
A comparative study of morphine treatment regimen prior to mating and during late pregnancy.
    Brain research bulletin, 2006, Jan-30, Volume: 68, Issue:5

    Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Behavior, Animal; Body Weight; Brain

2006
Sexual motivation is demasculinized, but not feminized, in prenatally stressed male rats.
    Neuroscience, 2006, Volume: 138, Issue:2

    Topics: Animals; Copulation; Dopamine; Female; Homovanillic Acid; Immobilization; Male; Motivation; Pregnanc

2006
Ontogeny of sensorimotor gating and immune impairment induced by prenatal immune challenge in rats: implications for the etiopathology of schizophrenia.
    Molecular psychiatry, 2010, Volume: 15, Issue:4

    Topics: 3,4-Dihydroxyphenylacetic Acid; Acoustic Stimulation; Age Factors; Analysis of Variance; Animals; An

2010
Ontogeny of sensorimotor gating and immune impairment induced by prenatal immune challenge in rats: implications for the etiopathology of schizophrenia.
    Molecular psychiatry, 2010, Volume: 15, Issue:4

    Topics: 3,4-Dihydroxyphenylacetic Acid; Acoustic Stimulation; Age Factors; Analysis of Variance; Animals; An

2010
Ontogeny of sensorimotor gating and immune impairment induced by prenatal immune challenge in rats: implications for the etiopathology of schizophrenia.
    Molecular psychiatry, 2010, Volume: 15, Issue:4

    Topics: 3,4-Dihydroxyphenylacetic Acid; Acoustic Stimulation; Age Factors; Analysis of Variance; Animals; An

2010
Ontogeny of sensorimotor gating and immune impairment induced by prenatal immune challenge in rats: implications for the etiopathology of schizophrenia.
    Molecular psychiatry, 2010, Volume: 15, Issue:4

    Topics: 3,4-Dihydroxyphenylacetic Acid; Acoustic Stimulation; Age Factors; Analysis of Variance; Animals; An

2010
Neurotoxicity induced by prenatal exposure to MPTP on the monoaminergic and peptidergic systems of the marmoset brain.
    Experimental neurology, 1995, Volume: 131, Issue:1

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Callithrix; Dopamine; Enkephalin, Methionine; Female

1995
Permanent dopaminergic alterations in the n. accumbens after prenatal stress.
    Pharmacology, biochemistry, and behavior, 1994, Volume: 49, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Chemistry; Dopamine; Female; Functional Laterality; H

1994
Cerebrospinal fluid monoamine precursors and metabolites in human neonates following in utero cocaine exposure: a preliminary study.
    Pediatrics, 1993, Volume: 92, Issue:1

    Topics: Biogenic Monoamines; Brain; Case-Control Studies; Cocaine; Dopamine; Dose-Response Relationship, Dru

1993
The effects of prenatal exposure to cocaine on the dopaminergic cells in the rat retina. An immunocytochemical and neurochemical study.
    Experimental eye research, 1996, Volume: 62, Issue:6

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Female; Homo

1996
Prenatal dexamethasone exposure alters brain monoamine metabolism and adrenocortical response in rat offspring.
    The American journal of physiology, 1997, Volume: 273, Issue:5

    Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenal Cortex; Aging; Analysis of Variance; Animals; Biogenic Monoa

1997
Effects of prenatal methylazoxymethanol treatment on striatal dopaminergic systems in rat brain.
    Neuroscience research, 1998, Volume: 30, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Autoradiography; Brain; Carrier Proteins; Corpus Striatum;

1998
Prenatal stress alters brain biogenic amine levels in primates.
    Development and psychopathology, 1998,Summer, Volume: 10, Issue:3

    Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Behavior, Animal; Biogenic Amines; Brain; Female; Ho

1998
Effects of prenatal exposure to styrene on neurochemical levels in rat brain.
    Toxicology letters, 1999, Apr-12, Volume: 105, Issue:3

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Animals, Newborn; Birth Weight; Brain; Brain Chemistry; Dop

1999
Effects of prenatal cocaine exposure on amphetamine-induced dopamine release in the caudate nucleus of the adult rabbit.
    Brain research, 1999, Jul-31, Volume: 836, Issue:1-2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Amphetamine; Animals; Caudate Nucleus; Cocaine; Dopamine; Dopamine U

1999
Fetal exposure to methamphetamine in utero stimulates development of serotonergic neurons in three-dimensional reaggregate tissue culture.
    Synapse (New York, N.Y.), 2002, Volume: 43, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Amphetamine-Related Disorders; Animals; Brain; Cell Aggregation; Cel

2002
Neurotoxic effect of prenatal exposure to MPTP on the dopaminergic systems of the marmoset brain.
    European journal of pharmacology, 1992, Jul-07, Volume: 217, Issue:2-3

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Adolescent; Animals; C

1992
Effects of prenatal diphenhydramine exposure on dopaminergic function in adult rats.
    Pharmacology, biochemistry, and behavior, 1991, Volume: 40, Issue:1

    Topics: Animals; Apomorphine; Copulation; Corpus Striatum; Diphenhydramine; Dopamine; Female; Homovanillic A

1991
Dopamine, serotonin, and acid metabolites in brain regions from the developing offspring of ethanol-treated rats.
    Journal of neurochemistry, 1985, Volume: 44, Issue:1

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Brain Chemistry; Chromatography, High Pressure Liqui

1985
Effects of perinatal vitamin B6 deficiency on dopaminergic neurochemistry.
    Journal of neurochemistry, 1987, Volume: 48, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Body Weight; Chromatography, High Pressure Liquid; Corpus S

1987
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