homovanillic acid has been researched along with Deficiency, Mental in 19 studies
Homovanillic Acid: A 3-O-methyl ETHER of (3,4-dihydroxyphenyl)acetic acid.
homovanillate : A hydroxy monocarboxylic acid anion which is obtained by deprotonation of the carboxy group of homovanillic acid.
homovanillic acid : A monocarboxylic acid that is the 3-O-methyl ether of (3,4-dihydroxyphenyl)acetic acid. It is a catecholamine metabolite.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a patient with the Lesch-Nyhan syndrome we found decreased spinal fluid 5-hydroxyindole acetic acid (5-HIAA), the major metabolite of serotonin, and decreased homovanillic acid (HVA), the major metabolite of dopamine, indicating a decrease in monoamine metabolism." | 7.66 | Effects of L-5-hydroxytryptophan on monoamine and amino acids turnover in the Lesch-Nyhan syndrome. ( Castells, S; Chakrabarti, C; Hurwic, M; Nyhan, WL; Perel, JM; Winsberg, BG, 1979) |
| "In 8 cases of typical neuroleptic malignant syndrome (NMS), homovanillic acid (HVA), 5-hydroxyindole acetic acid (5-HIAA), noradrenaline (NA), and 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG) levels in the cerebrospinal fluid (CSF) were assayed during both the active phase of NMS and after recovery." | 3.68 | Neuroleptic malignant syndrome: a study of CSF monoamine metabolism. ( Ishiguro, T; Nisijima, K, 1990) |
| "In a patient with the Lesch-Nyhan syndrome we found decreased spinal fluid 5-hydroxyindole acetic acid (5-HIAA), the major metabolite of serotonin, and decreased homovanillic acid (HVA), the major metabolite of dopamine, indicating a decrease in monoamine metabolism." | 3.66 | Effects of L-5-hydroxytryptophan on monoamine and amino acids turnover in the Lesch-Nyhan syndrome. ( Castells, S; Chakrabarti, C; Hurwic, M; Nyhan, WL; Perel, JM; Winsberg, BG, 1979) |
| "All AADCD patients were affected by intellectual disability and psychiatric disorders." | 1.72 | Long-term neurological and psychiatric outcomes in patients with aromatic l-amino acid decarboxylase deficiency. ( Battini, R; Carducci, C; Fusco, C; Leuzzi, V; Manti, F; Mastrangelo, M; Spagnoli, C; Tolve, M, 2022) |
| "The Fragile X syndrome, a common form of mental retardation in humans, is caused by silencing the fragile X mental retardation (FMR1) gene leading to the absence of the encoded fragile X mental retardation protein 1 (FMRP)." | 1.31 | Alterations of amino acids and monoamine metabolism in male Fmr1 knockout mice: a putative animal model of the human fragile X mental retardation syndrome. ( Braun, K; Gruss, M, 2001) |
| "In the group of 9 children with other psychoses, both the level of homovanillic acid and that of 5-hydroxy-indoleacetic acid was raised." | 1.27 | Childhood psychosis and monoamine metabolites in spinal fluid. ( Gillberg, C; Hamilton-Hellberg, C; Svennerholm, L, 1983) |
| "It is postulated that the seizures and neurological deterioration of the patient were related to a deficiency in the synthesis of biogenic amine neurotransmitters." | 1.26 | Biogenic amine synthesis defect in dihydropteridine reductase deficiency. ( Butler, IJ; Koslow, SH, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (57.89) | 18.7374 |
| 1990's | 5 (26.32) | 18.2507 |
| 2000's | 2 (10.53) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Manti, F | 1 |
| Mastrangelo, M | 1 |
| Battini, R | 1 |
| Carducci, C | 2 |
| Spagnoli, C | 1 |
| Fusco, C | 1 |
| Tolve, M | 1 |
| Leuzzi, V | 1 |
| Gibson, KM | 1 |
| Gupta, M | 1 |
| Pearl, PL | 1 |
| Tuchman, M | 1 |
| Vezina, LG | 1 |
| Snead, OC | 1 |
| Smit, LM | 1 |
| Jakobs, C | 1 |
| Gillberg, C | 1 |
| Svennerholm, L | 1 |
| Hamilton-Hellberg, C | 1 |
| Hameury, L | 1 |
| Roux, S | 1 |
| Barthélémy, C | 4 |
| Adrien, JL | 1 |
| Desombre, H | 1 |
| Sauvage, D | 1 |
| Garreau, B | 3 |
| Lelord, G | 4 |
| Lewis, MH | 1 |
| Bodfish, JW | 1 |
| Powell, SB | 1 |
| Wiest, K | 1 |
| Darling, M | 1 |
| Golden, RN | 1 |
| Gruss, M | 1 |
| Braun, K | 1 |
| Koslow, SH | 1 |
| Butler, IJ | 1 |
| Watts, RW | 1 |
| Chalmers, RA | 1 |
| Lawson, AM | 1 |
| Castells, S | 1 |
| Chakrabarti, C | 1 |
| Winsberg, BG | 1 |
| Hurwic, M | 1 |
| Perel, JM | 1 |
| Nyhan, WL | 1 |
| Ritvo, ER | 1 |
| Martineau, J | 2 |
| Jouve, J | 2 |
| Muh, JP | 3 |
| Nisijima, K | 1 |
| Ishiguro, T | 1 |
| Zeman, J | 1 |
| Böswart, J | 1 |
| Percy, AK | 1 |
| Zoghbi, H | 1 |
| Riccardi, VM | 1 |
| Nalini, K | 1 |
| Aroor, AR | 1 |
| Rao, A | 1 |
| Bruneau, N | 2 |
| Misionzhnik, EIu | 1 |
| Kogan, RD | 1 |
| Balandina, IuB | 1 |
| Turova, NF | 1 |
| Sazonova, NS | 1 |
| Mrochek, JE | 1 |
| Dinsmore, SR | 1 |
| Ohrt, DW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Stereotypies and Mental Retardation: Neurobiological Basis[NCT00491478] | Phase 3 | 0 participants | Interventional | 1992-09-30 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
19 other studies available for homovanillic acid and Deficiency, Mental
| Article | Year |
|---|---|
Long-term neurological and psychiatric outcomes in patients with aromatic l-amino acid decarboxylase deficiency.
Topics: Adolescent; Adult; Amino Acids; Aromatic-L-Amino-Acid Decarboxylases; Biogenic Amines; Child; Dopami | 2022 |
Significant behavioral disturbances in succinic semialdehyde dehydrogenase (SSADH) deficiency (gamma-hydroxybutyric aciduria).
Topics: Adult; Aldehyde Oxidoreductases; Atrophy; Cerebellum; Chromatography, High Pressure Liquid; Chromato | 2003 |
Childhood psychosis and monoamine metabolites in spinal fluid.
Topics: Adolescent; Age Factors; Autistic Disorder; Brain Diseases; Cerebral Palsy; Child; Child, Preschool; | 1983 |
Quantified multidimensional assessment of autism and other pervasive developmental disorders. Application for bioclinical research.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adolescent; Autistic Disorder; Brain; Child; Child Development Disor | 1995 |
Plasma HVA in adults with mental retardation and stereotyped behavior: biochemical evidence for a dopamine deficiency model.
Topics: Adolescent; Adult; Dopamine; Female; Homovanillic Acid; Humans; Intellectual Disability; Male; Middl | 1996 |
Alterations of amino acids and monoamine metabolism in male Fmr1 knockout mice: a putative animal model of the human fragile X mental retardation syndrome.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Alanine; Amino Acids; Animals; Aspartic Acid; Brain; Brain St | 2001 |
Biogenic amine synthesis defect in dihydropteridine reductase deficiency.
Topics: 5-Hydroxytryptophan; Biogenic Amines; Carbidopa; Dopamine; Homovanillic Acid; Humans; Hydroxyindolea | 1977 |
Abnormal organic acidurias in mentally retarded patients.
Topics: Acidosis; Acids; Adult; Benzoates; Child; Chromatography, Gas; Citrates; Female; Glycolates; Homovan | 1975 |
Effects of L-5-hydroxytryptophan on monoamine and amino acids turnover in the Lesch-Nyhan syndrome.
Topics: 5-Hydroxytryptophan; Amino Acids; Carbidopa; Dopamine; Homovanillic Acid; Humans; Hydroxyindoleaceti | 1979 |
Biochemical studies of children with the syndromes of autism, childhood schizophrenia and related developmental disabilities: a review.
Topics: Autistic Disorder; Blood Platelets; Brain; Bufotenin; Child; Dopamine beta-Hydroxylase; Homovanillic | 1977 |
Monoamines (serotonin and catecholamines) and their derivatives in infantile autism: age-related changes and drug effects.
Topics: 3,4-Dihydroxyphenylacetic Acid; Age Factors; Autistic Disorder; Catecholamines; Child; Child Develop | 1992 |
Neuroleptic malignant syndrome: a study of CSF monoamine metabolism.
Topics: Adult; Biogenic Monoamines; Bipolar Disorder; Depressive Disorder; Female; Homovanillic Acid; Humans | 1990 |
[Metabolites of neurotransmitters in the cerebrospinal fluid in children].
Topics: Adolescent; Child; Child, Preschool; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Infant; In | 1991 |
Rett syndrome: initial experience with an emerging clinical entity.
Topics: Adolescent; Biopsy; Child; Child Development; Child, Preschool; Electroencephalography; Female; Homo | 1985 |
Urinary levels of biogenic amine metabolites in mentally retarded children.
Topics: Adolescent; Biogenic Amines; Child; Creatinine; Female; Homovanillic Acid; Humans; Hydroxyindoleacet | 1988 |
Urinary homovanillic acid levels of autistic children.
Topics: Autistic Disorder; Child; Child, Preschool; Female; Homovanillic Acid; Humans; Intellectual Disabili | 1988 |
Developmental changes in ERPs and monoamine metabolites in normal, mentally retarded and autistic children.
Topics: Autistic Disorder; Child; Child Development; Child, Preschool; Evoked Potentials, Auditory; Homovani | 1987 |
[Clinico-pathogenetic correlations in intellectual deficiency in premature infants].
Topics: Autoantibodies; Brain; Catecholamines; Child; Homovanillic Acid; Humans; Infant, Newborn; Infant, Pr | 1985 |
Monitoring phenylalanine-tyrosine metabolism by high-resolution liquid chromatography of urine.
Topics: Aromatic Amino Acid Decarboxylase Inhibitors; Autistic Disorder; Carbidopa; Catechols; Child; Chroma | 1973 |