homovanillic acid has been researched along with Chronic Motor and Vocal Tic Disorder in 32 studies
Homovanillic Acid: A 3-O-methyl ETHER of (3,4-dihydroxyphenyl)acetic acid.
homovanillate : A hydroxy monocarboxylic acid anion which is obtained by deprotonation of the carboxy group of homovanillic acid.
homovanillic acid : A monocarboxylic acid that is the 3-O-methyl ether of (3,4-dihydroxyphenyl)acetic acid. It is a catecholamine metabolite.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Many studies have indicated that a variety of neurotransmitters are implicated in the pathophysiology of Tourette syndrome (TS), including dopamine (DA), serotonin (5-TH), homovanillic acid (HVA), and gamma-amino butyric acid (GABA)." | 5.16 | Effects of Chinese herbal medicine Ningdong granule on regulating dopamine (DA)/serotonin (5-TH) and gamma-amino butyric acid (GABA) in patients with Tourette syndrome. ( Li, A; Li, J; Qi, F; Wang, S; Zhao, L, 2012) |
| "To develop a mouse model to mimic the behavioral and neurochemical changes of Tourette syndrome (TS) by 1-(2, 5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) induction and to investigate the effects of fluoxetine and haloperidol on head twitch response (HTR) induced by DOI." | 3.74 | [Roles of fluoxetine and haloperidol in mouse models of DOI-induced head twitch response]. ( Dai, XM; Lu, Y; Ma, HW; Yao, Y, 2007) |
| "A prospective clinical and biochemical study on the effects of treatment with haloperidol has been performed in seven patients with Tourette syndrome." | 3.66 | Dopaminergic dsyfunction in Tourette syndrome. ( Butler, IJ; Coyle, JT; Seifert, WE; Singer, HS; Tune, LE, 1982) |
| "Tourette's syndrome is a chronic tic disorder in which motor and vocal tics begin in childhood, persist to adulthood, and occur predominantly in males, often in a familial setting." | 2.37 | Tourette's syndrome. Some new concepts. ( Butler, IJ, 1984) |
| "Rat models of Tourette's syndrome were established via intraperitoneal injection of apomorphine (Apo)." | 1.38 | Effects of ningdong granule on DA, DRD2, and HVA in a rat model of Tourette's syndrome. ( Li, AY; Lin, HY; Lin, Y; Lv, H; Yao, B; Zhao, H, 2012) |
| "Homovanillic acid levels were 65 and 60 ng/ml, respectively, and 5-hydroxyindoleacetic acid levels were 36 and 39 ng/ml." | 1.28 | Gilles de la Tourette's syndrome in twins: clinical and neurochemical data. ( Goetz, CG; Tanner, CM, 1990) |
| "The dopamine hypothesis for Tourette's syndrome proposes that the disorder is pathologically related either to an excessive amount of dopamine or to supersensitive receptors." | 1.28 | Abnormal dopamine uptake sites in postmortem striatum from patients with Tourette's syndrome. ( Hahn, IH; Moran, TH; Singer, HS, 1991) |
| "No debrisoquin was detected in cerebrospinal fluid samples." | 1.28 | Plasma debrisoquin levels in the assessment of reduction of plasma homovanillic acid. The debrisoquin method. ( Anderson, GM; Cho, SC; Cohen, DJ; Hardin, MT; Jatlow, PI; Leckman, JF; Riddle, MA, 1989) |
| "Clonidine's effectiveness in Tourette's syndrome may be dependent on changes in dopaminergic as well as adrenergic mechanisms." | 1.27 | Rebound phenomena in Tourette's syndrome after abrupt withdrawal of clonidine. Behavioral, cardiovascular, and neurochemical effects. ( Anderson, GM; Caruso, KA; Cohen, DJ; Leckman, JF; Ort, S; Riddle, MA, 1986) |
| "This longitudinal, blind study of Gilles de la Tourette's disease in a 44 year old male patient who was nonresponsive to Haloperidol therapy indicates that dopamine excretion is related to clinical response." | 1.26 | A study of endogenous dopamine metabolism in Gilles de la Tourette's disease. ( Knopp, W; Messiha, FS, 1976) |
| "In five patients with Tourette's syndrome, we found in the CSF an elevated probenecid-induced accumulation of HVA, the major metabolite of dopamine." | 1.26 | Gilles de la Tourette's syndrome: biochemical approaches. ( Bowers, MB; Jutkowitz, R; Rosenbaum, D; Van Woert, MH, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (65.63) | 18.7374 |
| 1990's | 4 (12.50) | 18.2507 |
| 2000's | 4 (12.50) | 29.6817 |
| 2010's | 3 (9.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, F | 1 |
| Li, A | 4 |
| Lv, H | 3 |
| Ma, H | 2 |
| Liu, F | 2 |
| Xu, H | 1 |
| Yao, B | 2 |
| Lin, HY | 1 |
| Zhao, H | 1 |
| Li, AY | 1 |
| Lin, Y | 1 |
| Wang, S | 1 |
| Qi, F | 1 |
| Li, J | 1 |
| Zhao, L | 1 |
| Yao, Y | 1 |
| Ma, HW | 1 |
| Lu, Y | 1 |
| Dai, XM | 1 |
| Butler, IJ | 3 |
| Singer, HS | 4 |
| Tune, LE | 1 |
| Seifert, WE | 2 |
| Coyle, JT | 1 |
| Leckman, JF | 11 |
| Cohen, DJ | 12 |
| Detlor, J | 1 |
| Harcherik, DF | 1 |
| Young, JG | 2 |
| Anderson, GM | 9 |
| Shaywitz, BA | 5 |
| Takano, K | 1 |
| Ishiguro, T | 1 |
| Oades, RD | 1 |
| Moskowitz, MA | 1 |
| Wurtman, RJ | 1 |
| Caparulo, B | 1 |
| Bowers, MB | 2 |
| Koslow, SH | 1 |
| Caprioli, RM | 1 |
| Messiha, FS | 1 |
| Knopp, W | 1 |
| Van Woert, MH | 1 |
| Jutkowitz, R | 1 |
| Rosenbaum, D | 1 |
| Lal, S | 1 |
| Allen, J | 1 |
| Etienne, P | 1 |
| Sourkes, TL | 1 |
| Humphreys, P | 1 |
| Pollak, ES | 1 |
| Chatterjee, D | 1 |
| Riddle, MA | 9 |
| Goetz, CG | 1 |
| Tanner, CM | 1 |
| Hahn, IH | 1 |
| Moran, TH | 1 |
| Bornstein, RA | 1 |
| Baker, GB | 1 |
| Berrettini, WH | 1 |
| Hardin, M | 1 |
| Chappell, P | 1 |
| Bissette, G | 1 |
| Nemeroff, CB | 1 |
| Goodman, WK | 1 |
| Jatlow, PI | 1 |
| Cho, SC | 1 |
| Hardin, MT | 5 |
| Ort, SI | 5 |
| Stevenson, J | 2 |
| Shaywitz, SE | 1 |
| Ort, S | 1 |
| Caruso, KA | 2 |
| Anderson, M | 1 |
| Towbin, KE | 1 |
| Johannsson, B | 1 |
| Roos, BE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Double-Blind, Placebo-Controlled Trial Evaluating the Efficacy and Safety of Yi-Gan San in Children and Adolescents With Tourette's Disorder[NCT03564132] | Phase 2 | 38 participants (Actual) | Interventional | 2018-06-16 | Completed | ||
| [NCT00004325] | 200 participants | Observational | 1988-12-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for homovanillic acid and Chronic Motor and Vocal Tic Disorder
| Article | Year |
|---|---|
Tourette's syndrome. Some new concepts.
Topics: Antipsychotic Agents; Female; Haloperidol; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male | 1984 |
Recent advances in Gilles de la Tourette syndrome: implications for clinical practice and future research.
Topics: Adolescent; Age Factors; Attention Deficit Disorder with Hyperactivity; Child; Clonidine; Compulsive | 1983 |
Catecholamines and neurologic diseases (second of two parts).
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Brain; Brain Diseases; Catecholamines; Cereb | 1975 |
1 trial available for homovanillic acid and Chronic Motor and Vocal Tic Disorder
| Article | Year |
|---|---|
Effects of Chinese herbal medicine Ningdong granule on regulating dopamine (DA)/serotonin (5-TH) and gamma-amino butyric acid (GABA) in patients with Tourette syndrome.
Topics: Adolescent; Child; Dopamine; Drugs, Chinese Herbal; Enzyme-Linked Immunosorbent Assay; Female; gamma | 2012 |
28 other studies available for homovanillic acid and Chronic Motor and Vocal Tic Disorder
| Article | Year |
|---|---|
Dual regulating effects of gastrodin on extracellular dopamine concentration in rats models of Tourette's syndrome.
Topics: Animals; Apomorphine; Benzyl Alcohols; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine P | 2015 |
Effects of Ningdong granule on the dopamine system of Tourette's syndrome rat models.
Topics: Animals; Apomorphine; Behavior, Animal; Chemistry, Pharmaceutical; Dopamine; Dopamine Agents; Dopami | 2009 |
Effects of gastrodin on the dopamine system of Tourette's syndrome rat models.
Topics: Animals; Apomorphine; Benzyl Alcohols; Dopamine; Glucosides; Homovanillic Acid; Injections, Intraper | 2009 |
Effects of ningdong granule on DA, DRD2, and HVA in a rat model of Tourette's syndrome.
Topics: Animals; Corpus Striatum; Dopamine; Drugs, Chinese Herbal; Homovanillic Acid; Male; Rats; Rats, Wist | 2012 |
[Roles of fluoxetine and haloperidol in mouse models of DOI-induced head twitch response].
Topics: Amphetamines; Animals; Disease Models, Animal; Dopamine; Fluoxetine; Haloperidol; Homovanillic Acid; | 2007 |
Dopaminergic dsyfunction in Tourette syndrome.
Topics: Adolescent; Dopamine; Female; Haloperidol; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male | 1982 |
Acute and chronic clonidine treatment in Tourette's syndrome: a preliminary report on clinical response and effect on plasma and urinary catecholamine metabolites, growth hormone, and blood pressure.
Topics: Adolescent; Blood Pressure; Catecholamines; Child; Clonidine; Double-Blind Method; Growth Hormone; H | 1983 |
Tics and Tourette syndrome.
Topics: Adolescent; Adult; Child; Child, Preschool; Dopamine; Female; Haloperidol; Homovanillic Acid; Humans | 1982 |
[A study of clinical pictures and monoamine metabolism of Gilles de la Tourette syndrome].
Topics: Adolescent; Adult; Biogenic Monoamines; Child; Echolalia; Haloperidol; Homovanillic Acid; Humans; Hy | 1993 |
Differential measures of 'sustained attention' in children with attention-deficit/hyperactivity or tic disorders: relations to monoamine metabolism.
Topics: Adolescent; Attention; Attention Deficit Disorder with Hyperactivity; Biogenic Monoamines; Case-Cont | 2000 |
Chronic, multiple tics of Gilles de la Tourette's disease. CSF acid monoamine metabolites after probenecid administration.
Topics: Adolescent; Brain; Child; Dextroamphetamine; Dopamine; Female; Homovanillic Acid; Humans; Hydroxyind | 1978 |
Biogenic amine metabolism in Tourette syndrome.
Topics: Biogenic Amines; Child; Child, Preschool; Dopamine; Female; Homovanillic Acid; Humans; Hydroxyindole | 1979 |
A study of endogenous dopamine metabolism in Gilles de la Tourette's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Dopamine; Epinephrine; Haloperidol; Homovanillic Acid; Humans | 1976 |
Gilles de la Tourette's syndrome: biochemical approaches.
Topics: Haloperidol; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Tourette Syndrome | 1976 |
Dopaminergic function in Gilles de la Tourette's syndrome, Sydenham's chorea and torsion dystonia.
Topics: Adolescent; Adult; Apomorphine; Child; Chorea; Dopamine; Dystonia Musculorum Deformans; Female; Halo | 1976 |
Brain monoamines and amino acids in Gilles de la Tourette's syndrome: a preliminary study of subcortical regions.
Topics: Adult; Aged; Amino Acids; Biogenic Monoamines; Brain Chemistry; Chromatography, High Pressure Liquid | 1992 |
Gilles de la Tourette's syndrome in twins: clinical and neurochemical data.
Topics: Child; Diseases in Twins; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; Tourette Syndro | 1990 |
Abnormal dopamine uptake sites in postmortem striatum from patients with Tourette's syndrome.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Caudate Nucleus; Chromatography, High Pressure Liquid; Corpus | 1991 |
Neuropsychological correlates of urinary amine metabolites in Tourette's syndrome.
Topics: Adolescent; Adult; Child; Female; Glycols; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male | 1988 |
Elevated CSF dynorphin A [1-8] in Tourette's syndrome.
Topics: Dynorphins; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Methoxyhydroxyphenylglycol; Peptide | 1988 |
Plasma debrisoquin levels in the assessment of reduction of plasma homovanillic acid. The debrisoquin method.
Topics: Adult; Debrisoquin; Dose-Response Relationship, Drug; Female; Homovanillic Acid; Humans; Isoquinolin | 1989 |
Tourette's syndrome: clinical and neurochemical correlates.
Topics: Adolescent; Adult; Child; Female; Glycols; Homovanillic Acid; Humans; Male; Methoxyhydroxyphenylglyc | 1988 |
Brief debrisoquin administration to assess central dopaminergic function in children.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Child; Debrisoquin; Dopamine; Female; Hom | 1986 |
Rebound phenomena in Tourette's syndrome after abrupt withdrawal of clonidine. Behavioral, cardiovascular, and neurochemical effects.
Topics: Adolescent; Blood Pressure; Child; Clonidine; Epinephrine; Homovanillic Acid; Humans; Male; Methoxyh | 1986 |
Assessment of central dopaminergic function using plasma-free homovanillic acid after debrisoquin administration.
Topics: Adolescent; Adult; Blood Pressure; Brain; Child; Debrisoquin; Dopamine; Female; Homovanillic Acid; H | 1986 |
Plasma-free homovanillic acid: within- and across-day stability in children and adults with Tourette's syndrome.
Topics: Adolescent; Adult; Child; Circadian Rhythm; Female; Homovanillic Acid; Humans; Male; Middle Aged; Ti | 1987 |
Assessment of dopaminergic function in children and adults: long and brief debrisoquin administration combined with plasma homovanillic acid.
Topics: Adult; Child; Debrisoquin; Dopamine; Homovanillic Acid; Humans; Isoquinolines; Tourette Syndrome | 1987 |
5-Hydroxyindoleacetic acid and homovanillic acid in cerebrospinal fluid of patients with neurological diseases.
Topics: Adult; Brain Neoplasms; Central Nervous System Diseases; Cerebellar Ataxia; Cerebrovascular Disorder | 1974 |