Page last updated: 2024-10-21

homovanillic acid and Carcinoid Tumor

homovanillic acid has been researched along with Carcinoid Tumor in 4 studies

Homovanillic Acid: A 3-O-methyl ETHER of (3,4-dihydroxyphenyl)acetic acid.
homovanillate : A hydroxy monocarboxylic acid anion which is obtained by deprotonation of the carboxy group of homovanillic acid.
homovanillic acid : A monocarboxylic acid that is the 3-O-methyl ether of (3,4-dihydroxyphenyl)acetic acid. It is a catecholamine metabolite.

Carcinoid Tumor: A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182)

Research Excerpts

ExcerptRelevanceReference
"Urinary vanillylmandelic acid (VMA) and homovanillic acid (HVA) are biomarkers for the diagnosis and follow-up of neuroblastoma, whereas urinary 5-hydroxyindoleacetic acid (5-HIAA) is used to assess a carcinoid tumor."3.88Quantification of vanillylmandelic acid, homovanillic acid and 5-hydroxyindoleacetic acid in urine using a dilute-and-shoot and ultra-high pressure liquid chromatography tandem mass spectrometry method. ( Centeno, C; Eugster, PJ; Grouzmann, E, 2018)
"The urinary excretion of vanillylmandelic acid (VMA), homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) can be increased in the presence of neuroblastic and carcinoid tumors."3.74HPLC-mass spectrometry method for quantitative detection of neuroendocrine tumor markers: vanillylmandelic acid, homovanillic acid and 5-hydroxyindoleacetic acid. ( Cardelli, P; Lionetto, L; Lostia, AM; Simmaco, M; Stigliano, A, 2008)
" Consequently, this reaction has long been used to measure tyrosine in tyrosinosis and tyrosinemia, homovanillic acid in neuroblastoma, and 5-hydroxy-3-indoleacetic acid in the carcinoid tumor."3.66The chemical basis and specificity of the nitrosonaphthol reaction. ( Knight, JA; Robertson, G; Wu, JT, 1983)
"Although both carcinoid tumors and pheochromocytomas arise from neural crest origin, they are thought to each secrete distinctive monoamines; carcinoid tumors, which contain tryptophan hydroxylase, secrete serotonin, and pheochromocytomas, which contain tyrosine hydroxylase, may secrete dopamine (DA), norepinephrine (NE), or epinephrine (E)."1.27Increased dopamine production in patients with carcinoid tumors. ( Feldman, JM, 1985)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19902 (50.00)18.7374
1990's0 (0.00)18.2507
2000's1 (25.00)29.6817
2010's1 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Grouzmann, E1
Centeno, C1
Eugster, PJ1
Lionetto, L1
Lostia, AM1
Stigliano, A1
Cardelli, P1
Simmaco, M1
Knight, JA1
Robertson, G1
Wu, JT1
Feldman, JM1

Other Studies

4 other studies available for homovanillic acid and Carcinoid Tumor

ArticleYear
Quantification of vanillylmandelic acid, homovanillic acid and 5-hydroxyindoleacetic acid in urine using a dilute-and-shoot and ultra-high pressure liquid chromatography tandem mass spectrometry method.
    Clinical chemistry and laboratory medicine, 2018, 08-28, Volume: 56, Issue:9

    Topics: Biomarkers; Calibration; Carcinoid Tumor; Chromatography, High Pressure Liquid; Homovanillic Acid; H

2018
HPLC-mass spectrometry method for quantitative detection of neuroendocrine tumor markers: vanillylmandelic acid, homovanillic acid and 5-hydroxyindoleacetic acid.
    Clinica chimica acta; international journal of clinical chemistry, 2008, Volume: 398, Issue:1-2

    Topics: Biomarkers, Tumor; Calibration; Carcinoid Tumor; Chromatography, High Pressure Liquid; Homovanillic

2008
The chemical basis and specificity of the nitrosonaphthol reaction.
    Clinical chemistry, 1983, Volume: 29, Issue:11

    Topics: Amino Acid Metabolism, Inborn Errors; Carcinoid Tumor; Chemical Phenomena; Chemistry; Guaiacol; Homo

1983
Increased dopamine production in patients with carcinoid tumors.
    Metabolism: clinical and experimental, 1985, Volume: 34, Issue:3

    Topics: Adult; Aged; Carcinoid Tumor; Chromatography, Thin Layer; Dopamine; Epinephrine; Female; Homovanilli

1985