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homovanillic acid and Brain Diseases

homovanillic acid has been researched along with Brain Diseases in 36 studies

Homovanillic Acid: A 3-O-methyl ETHER of (3,4-dihydroxyphenyl)acetic acid.
homovanillate : A hydroxy monocarboxylic acid anion which is obtained by deprotonation of the carboxy group of homovanillic acid.
homovanillic acid : A monocarboxylic acid that is the 3-O-methyl ether of (3,4-dihydroxyphenyl)acetic acid. It is a catecholamine metabolite.

Brain Diseases: Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.

Research Excerpts

ExcerptRelevanceReference
"Of five comatose patients, two had cerebrovascular lesions and three had sustained head injury, and, in four of the five, the values of either one or both of HVA and 5-HIAA were low, but in the fifth case the 5-HIAA value was high."5.26Homovanillic acid and 5-hydroxyindoleacetic acid in the ventricular CSF of comatose patients with obstructive hydrocephalus. ( Inagawa, T; Ishikawa, S; Uozumi, T, 1980)
"Baseline concentrations of homovanillic acid (HVA), 5-hydroxyindole acetic acid (5-HIAA) and MHPG in the cerebrospinal fluid (CSF) were determined in 67 lobotomized and 30 non-lobotomized patients with chronic schizophrenia."3.66Monoamine metabolite levels in cerebrospinal fluid and brain atrophy in lobotomized schizophrenic patients. ( Hyyppä, S; Kampman, R; Myllylä, V; Ranta, P; Rimón, R; Roos, BE, 1979)
" All of these effects of ATR were observed at levels that were not toxic to the tissue, as LDH release into the medium (lactate dehydrogenase, an index of non-specific cytotoxicity) was not affected by ATR."1.34Dopaminergic toxicity of the herbicide atrazine in rat striatal slices. ( Carr, RL; Filipov, NM; Sistrunk, SC; Stewart, MA, 2007)
"Homovanillic acid (HVA) is a metabolite of dopamine, reflecting central dopamine metabolism, primarily situated in the striatum."1.32Decreased homovanillic acid concentrations in cerebrospinal fluid in children without a known defect in dopamine metabolism. ( Rotteveel, JJ; Van Der Heyden, JC; Wevers, RA, 2003)
"In the group of 9 children with other psychoses, both the level of homovanillic acid and that of 5-hydroxy-indoleacetic acid was raised."1.27Childhood psychosis and monoamine metabolites in spinal fluid. ( Gillberg, C; Hamilton-Hellberg, C; Svennerholm, L, 1983)
"Of five comatose patients, two had cerebrovascular lesions and three had sustained head injury, and, in four of the five, the values of either one or both of HVA and 5-HIAA were low, but in the fifth case the 5-HIAA value was high."1.26Homovanillic acid and 5-hydroxyindoleacetic acid in the ventricular CSF of comatose patients with obstructive hydrocephalus. ( Inagawa, T; Ishikawa, S; Uozumi, T, 1980)
"The subjects with encephalopathy had raised plasma free tryptophan, CSF tryptophan, and CSF 5-hydroxyindoleacetic acid."1.26Cerebral transmitter precursors and metabolites in advanced renal disease. ( Callaghan, N; Curzon, G; Kantamaneni, BD; Murnaghan, D; Sullivan, PA, 1978)

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-199023 (63.89)18.7374
1990's7 (19.44)18.2507
2000's5 (13.89)29.6817
2010's1 (2.78)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Winter, C1
Djodari-Irani, A1
Sohr, R1
Morgenstern, R1
Feldon, J1
Juckel, G1
Meyer, U1
Willemsen, MA1
Verbeek, MM1
Kamsteeg, EJ1
de Rijk-van Andel, JF1
Aeby, A1
Blau, N1
Burlina, A1
Donati, MA1
Geurtz, B1
Grattan-Smith, PJ1
Haeussler, M1
Hoffmann, GF1
Jung, H1
de Klerk, JB1
van der Knaap, MS1
Kok, F1
Leuzzi, V1
de Lonlay, P1
Megarbane, A1
Monaghan, H1
Renier, WO1
Rondot, P1
Ryan, MM1
Seeger, J1
Smeitink, JA1
Steenbergen-Spanjers, GC1
Wassmer, E1
Weschke, B1
Wijburg, FA1
Wilcken, B1
Zafeiriou, DI1
Wevers, RA2
Van Der Heyden, JC1
Rotteveel, JJ1
Moroz, IA1
Peciña, S1
Schallert, T1
Stewart, J1
Filipov, NM1
Stewart, MA1
Carr, RL1
Sistrunk, SC1
Inagawa, T1
Ishikawa, S1
Uozumi, T1
Yamamoto, M1
Otsuki, S1
Miyake, K1
Namba, R1
Gillberg, C1
Svennerholm, L1
Hamilton-Hellberg, C1
Melamed, E1
Hefti, F1
Bird, ED1
Arias, J1
Alsasua, A1
Estebánez, E1
López, ML1
Arias, JI1
Durán, M1
García de Jalón, PD1
Durán Sacristán, H1
Gil-Nagel, A1
Morlán, L1
Balseiro, J1
García de Yébenes, J1
Cabello, A1
Martínez-Martín, P1
Hossain, MA1
Weiner, N1
Xia, XG1
Schmidt, N1
Teismann, P1
Ferger, B1
Schulz, JB1
Sullivan, PA1
Murnaghan, D1
Callaghan, N1
Kantamaneni, BD2
Curzon, G2
Passouant, P1
Billiard, M1
Besset, A1
Renaud, B1
Moskowitz, MA1
Wurtman, RJ1
Rimón, R1
Roos, BE2
Kampman, R1
Hyyppä, S1
Ranta, P1
Myllylä, V1
Rosenberg, RN2
Nyhan, WL2
Bay, C2
Shore, P1
Michel, D1
Tommasi, M1
Laurent, B1
Trillet, M1
Schott, B1
Bridges, PK1
Bartlett, JR1
Sepping, P1
Siever, L1
Kraemer, H1
Sack, R1
Angwin, P1
Berger, P1
Zarcone, V1
Barchas, J1
Brodie, HK1
Amin, F1
Davidson, M1
Davis, KL1
Gordon, K1
Statman, D1
Johnston, MV2
Robinson, TE2
Becker, JB1
Silverstein, FS2
Degrell, I1
Nagy, E1
Castañeda, E1
Whishaw, IQ1
Riley, DE1
Lang, AE1
Lewis, A1
Resch, L1
Ashby, P1
Hornykiewicz, O2
Black, S1
Kish, SJ1
Gilbert, JJ1
Chang, LJ1
Mirchandani, L1
Shannak, K1
Bradbury, AJ1
Costall, B1
Domeney, AM1
Testa, B1
Jenner, PG1
Marsden, CD1
Naylor, RJ1
Nakamura, S1
Greenberg, H1
Knutsen, CA1
Chandler, W1
Phillips, T1
Ensminger, WD1
Scheinin, M1
Fibiger, HC1
LePiane, FG1
Jakubovic, A1
Phillips, AG1
Lakke, JP1
Korf, J1
van Praag, HM1
Minderhoud, JM1
Schut, T1
Garelis, E1
Sourkes, TL1
Lycke, E1

Reviews

3 reviews available for homovanillic acid and Brain Diseases

ArticleYear
Catecholamines and neurologic diseases (second of two parts).
    The New England journal of medicine, 1975, Aug-14, Volume: 293, Issue:7

    Topics: Animals; Attention Deficit Disorder with Hyperactivity; Brain; Brain Diseases; Catecholamines; Cereb

1975
Homovanillic acid measurement in clinical research: a review of methodology.
    Schizophrenia bulletin, 1992, Volume: 18, Issue:1

    Topics: Body Fluids; Brain Diseases; Female; Homovanillic Acid; Humans; Male; Schizophrenia

1992
Monoamine metabolites in human cerebrospinal fluid: indicators of neuronal activity?
    Medical biology, 1985, Volume: 63, Issue:1

    Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Biogenic Amines; Brain Diseases; Glycols; Homo

1985

Other Studies

33 other studies available for homovanillic acid and Brain Diseases

ArticleYear
Prenatal immune activation leads to multiple changes in basal neurotransmitter levels in the adult brain: implications for brain disorders of neurodevelopmental origin such as schizophrenia.
    The international journal of neuropsychopharmacology, 2009, Volume: 12, Issue:4

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Chemistry; Brain Diseases; Chromatography, High Press

2009
Tyrosine hydroxylase deficiency: a treatable disorder of brain catecholamine biosynthesis.
    Brain : a journal of neurology, 2010, Volume: 133, Issue:Pt 6

    Topics: Age of Onset; Amino Acid Metabolism, Inborn Errors; Brain; Brain Diseases; Catecholamines; Child, Pr

2010
Decreased homovanillic acid concentrations in cerebrospinal fluid in children without a known defect in dopamine metabolism.
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2003, Volume: 7, Issue:1

    Topics: Adolescent; Age Factors; Brain Diseases; Child; Child, Preschool; Dopamine; Homovanillic Acid; Human

2003
Sparing of behavior and basal extracellular dopamine after 6-hydroxydopamine lesions of the nigrostriatal pathway in rats exposed to a prelesion sensitizing regimen of amphetamine.
    Experimental neurology, 2004, Volume: 189, Issue:1

    Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic Agents; Amphetamine; Analysis of Variance; Animals; Behav

2004
Dopaminergic toxicity of the herbicide atrazine in rat striatal slices.
    Toxicology, 2007, Mar-22, Volume: 232, Issue:1-2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Atrazine; Brain Diseases; Corpus Striatum; Dopamine; Dopami

2007
Homovanillic acid and 5-hydroxyindoleacetic acid in the ventricular CSF of comatose patients with obstructive hydrocephalus.
    Journal of neurosurgery, 1980, Volume: 52, Issue:5

    Topics: Adolescent; Adult; Brain Diseases; Brain Neoplasms; Child; Coma; Craniopharyngioma; Ependymoma; Fema

1980
[Lumbar cerebrospinal fluid levels of GABA, HVA and 5HIAA in various patients with choreic movement and effects with isoniazid treatment].
    No to shinkei = Brain and nerve, 1983, Volume: 35, Issue:5

    Topics: Acanthocytes; Adult; Aged; Atrophy; Brain Diseases; Chorea; gamma-Aminobutyric Acid; Homovanillic Ac

1983
Childhood psychosis and monoamine metabolites in spinal fluid.
    Journal of autism and developmental disorders, 1983, Volume: 13, Issue:4

    Topics: Adolescent; Age Factors; Autistic Disorder; Brain Diseases; Cerebral Palsy; Child; Child, Preschool;

1983
Huntington chorea is not associated with hyperactivity of nigrostriatal dopaminergic neurons: studies in postmortem tissues and in rats with kainic acid lesions.
    Neurology, 1982, Volume: 32, Issue:6

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Diseases; Corpus Striatum; Dopamine; Female; Homovani

1982
[Experimental portosystemic encephalopathy: values of noradrenaline, dopamine, and homovanillic acid in the CNS of rats at 15, 30 and 60 days after terminolateral porto-caval anastomosis].
    Revista espanola de las enfermedades del aparato digestivo, 1982, Volume: 61, Issue:2

    Topics: Animals; Brain Chemistry; Brain Diseases; Dopamine; Homovanillic Acid; Male; Norepinephrine; Phenyla

1982
[Neuro-acanthocytosis with associated myopathy. A case report].
    Neurologia (Barcelona, Spain), 1994, Volume: 9, Issue:4

    Topics: Acanthocytes; Adult; Basal Ganglia; Basophils; Brain Diseases; Cerebellum; Denervation; Homovanillic

1994
Dopaminergic functional supersensitivity: effects of chronic L-dopa and carbidopa treatment in an animal model of Parkinson's disease.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 267, Issue:3

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biopterins; Brain Diseases; Carbidopa; Corpus Striatum; Cyc

1993
Dopamine mediates striatal malonate toxicity via dopamine transporter-dependent generation of reactive oxygen species and D2 but not D1 receptor activation.
    Journal of neurochemistry, 2001, Volume: 79, Issue:1

    Topics: 3,4-Dihydroxyphenylacetic Acid; alpha-Methyltyrosine; Animals; Benzazepines; Brain Diseases; Carbido

2001
Cerebral transmitter precursors and metabolites in advanced renal disease.
    Journal of neurology, neurosurgery, and psychiatry, 1978, Volume: 41, Issue:7

    Topics: Adult; Aged; Brain; Brain Diseases; Fatty Acids, Nonesterified; Female; Homovanillic Acid; Humans; H

1978
Encephalopathy associated with bismuth salt ingestion and brain monoamines.
    International journal of neurology, 1979, Volume: 13, Issue:1-4

    Topics: Adult; Aged; Bismuth; Brain Diseases; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; M

1979
Monoamine metabolite levels in cerebrospinal fluid and brain atrophy in lobotomized schizophrenic patients.
    Annals of clinical research, 1979, Volume: 11, Issue:1

    Topics: Atrophy; Brain Diseases; Female; Glycols; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male;

1979
Autosomal dominant striatonigral degeneration. A clinical, pathologic, and biochemical study of a new genetic disorder.
    Neurology, 1976, Volume: 26, Issue:8

    Topics: Adult; Aged; Brain Diseases; Caudate Nucleus; Cerebellar Nuclei; Corpus Striatum; Eye Movements; Fem

1976
[Striato-nigral degeneration. A propos of 2 anatomo-clinical cases].
    Revue neurologique, 1976, Volume: 132, Issue:1

    Topics: Brain Diseases; Corpus Striatum; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male;

1976
Precursors and metabolites of 5-hydroxytryptamine and dopamine in the ventricular cerebrospinal fluid of psychiatric patients.
    Psychological medicine, 1976, Volume: 6, Issue:3

    Topics: Adult; Aged; Anxiety Disorders; Brain Diseases; Cerebral Ventricles; Depression; Female; Homovanilli

1976
Autosomal dominant striatonigral degeneration: a clinical, pathological, and biochemical study of a new genetic disorder.
    Transactions of the American Neurological Association, 1976, Volume: 101

    Topics: Adult; Brain Diseases; Corpus Striatum; Dopamine; Female; Genes, Dominant; Homovanillic Acid; Humans

1976
Gradients of biogenic amine metabolites in cerebrospinal fluid.
    Diseases of the nervous system, 1975, Volume: 36, Issue:1

    Topics: Alzheimer Disease; Amphetamine; Brain Diseases; Brain Neoplasms; Depression; Homovanillic Acid; Huma

1975
Transient hypoxia alters striatal catecholamine metabolism in immature brain: an in vivo microdialysis study.
    Journal of neurochemistry, 1990, Volume: 54, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Animals, Newborn; Brain Diseases; Corpus Striatum; Dialysis

1990
Correlations between cisternal CSF and plasma concentrations of HVA, MHPG, 5-HIAA, DA, and NA.
    Biological psychiatry, 1990, May-15, Volume: 27, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Blood-Brain Barrier; Brain; Brain Diseases; Dopamine; Female; Glycol

1990
Changes in striatal dopamine neurotransmission assessed with microdialysis following recovery from a bilateral 6-OHDA lesion: variation as a function of lesion size.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1990, Volume: 10, Issue:6

    Topics: 3,4-Dihydroxyphenylacetic Acid; Amphetamine; Animals; Brain Diseases; Corpus Striatum; Dialysis; Dop

1990
Cortical-basal ganglionic degeneration.
    Neurology, 1990, Volume: 40, Issue:8

    Topics: Aged; Autopsy; Basal Ganglia; Basal Ganglia Diseases; Brain Chemistry; Brain Diseases; Cerebral Cort

1990
Brain neurotransmitter abnormalities in neuronal intranuclear inclusion body disorder.
    Annals of neurology, 1985, Volume: 17, Issue:4

    Topics: Adolescent; Brain; Brain Diseases; Dopamine; Female; gamma-Aminobutyric Acid; Homovanillic Acid; Hum

1985
The toxic actions of MPTP and its metabolite MPP+ are not mimicked by analogues of MPTP lacking an N-methyl moiety.
    Neuroscience letters, 1985, Oct-24, Volume: 61, Issue:1-2

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; 3,4-Dihydroxyphenylacetic

1985
[Neurotransmitters and degenerative diseases in the central nervous system].
    Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics, 1986, Volume: 23, Issue:1

    Topics: Acetylcholinesterase; Aged; Aging; Brain Diseases; Dementia; Dopamine; Homovanillic Acid; Humans; Hy

1986
Effects of intraventricular methotrexate on cerebrospinal fluid monoamine metabolites in rhesus monkeys.
    Cancer treatment reports, 1986, Volume: 70, Issue:10

    Topics: Animals; Brain Diseases; Cerebral Ventricles; Dopamine; Homovanillic Acid; Hydroxyindoleacetic Acid;

1986
The role of dopamine in intracranial self-stimulation of the ventral tegmental area.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1987, Volume: 7, Issue:12

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Diseases; Corpus Striatum; Dopamine; Electric Stimula

1987
Clinical significance of probenecid test.
    Lancet (London, England), 1973, Mar-17, Volume: 1, Issue:7803

    Topics: Brain Diseases; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Parkinson Disease; Phenylacetat

1973
Use of cerebrospinal fluid drawn at pneumoencephalography in the study of monoamine metabolism in man.
    Journal of neurology, neurosurgery, and psychiatry, 1974, Volume: 37, Issue:6

    Topics: Adolescent; Adult; Brain Diseases; Epilepsy, Temporal Lobe; Epilepsy, Tonic-Clonic; Female; Homovani

1974
Viral infections in the central nervous system and 5-hydroxytryptamine metabolism.
    Advances in biochemical psychopharmacology, 1974, Volume: 11, Issue:0

    Topics: Animals; Brain; Brain Diseases; Catecholamines; Coxsackievirus Infections; Dopamine; Encephalitis; H

1974