homovanillic acid has been researched along with Autism in 41 studies
Homovanillic Acid: A 3-O-methyl ETHER of (3,4-dihydroxyphenyl)acetic acid.
homovanillate : A hydroxy monocarboxylic acid anion which is obtained by deprotonation of the carboxy group of homovanillic acid.
homovanillic acid : A monocarboxylic acid that is the 3-O-methyl ether of (3,4-dihydroxyphenyl)acetic acid. It is a catecholamine metabolite.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Based on data including urinary serotonin and 5-hydroxyindoleacetic acid, platelet serotonin uptake and efflux, platelet monoamine oxidase and glutathione peroxidase activities, and uric acid and plasma tryptophan, the origin(s) of such hyperserotonemia in autism appear(s) to be of metabolic origin, i." | 3.67 | Serotonin metabolism and other biochemical parameters in infantile autism. A controlled study of 22 autistic children. ( Braconnier, A; Bursztejn, C; Dreux, C; Ferrari, P; Haimart, M; Launay, JM; Luong, C; Pasques-Bondoux, D; Tabuteau, F, 1988) |
| "After administration of secretin, the Autism Diagnostic Interview-Revised (ADI-R) score improved in 7 of the 12 children." | 2.72 | Administration of secretin for autism alters dopamine metabolism in the central nervous system. ( Hashimoto, T; Kagami, S; Kuroda, Y; Miyazaki, M; Mori, K; Nozaki, S; Toda, Y; Watanabe, Y, 2006) |
| "Food allergy has been suggested to contribute to the expression of psychological and psychiatric traits, including disturbed social behaviour and repetitive behaviour inherent in autism spectrum disorders (ASD)." | 1.40 | Autistic-like behavioural and neurochemical changes in a mouse model of food allergy. ( Borre, Y; de Theije, CG; Garssen, J; Kas, MJ; Koelink, PJ; Korte, SM; Korte-Bouws, GA; Kraneveld, AD; Lopes da Silva, S; Olivier, B; Wu, J, 2014) |
| "In the group of 9 children with other psychoses, both the level of homovanillic acid and that of 5-hydroxy-indoleacetic acid was raised." | 1.27 | Childhood psychosis and monoamine metabolites in spinal fluid. ( Gillberg, C; Hamilton-Hellberg, C; Svennerholm, L, 1983) |
| " Urinary HVA dosage was performed on samples of urine taken after a 48-h tyrosine-free diet." | 1.27 | [Relation between auditory evoked potentials (presence, amplitude) during sound and light conditioning and levels of dopamine derivatives in infantile autism]. ( Barthelemy, C; Bruneau, N; Garreau, B; Lelord, G; Martineau, J; Tanguay, P, 1984) |
| "The Rett syndrome is a progressive disorder in female patients that is characterized by autistic behavior, dementia, ataxia, loss of purposeful use of the hands, and seizures." | 1.27 | Reduction of biogenic amine levels in the Rett syndrome. ( Butler, IJ; Glaze, DG; Percy, AK; Riccardi, VM; Zoghbi, HY, 1985) |
| "The favourable action of vitamin B6 on autism, reported by anglosaxon authors, was confirmed in 15 of the children." | 1.26 | [Modifications in urinary homovanillic acid after ingestion of vitamin B6; functional study in autistic children (author's transl)]. ( Arlot, JC; Callaway, E; Domenech, J; Garreau, B; Lelord, G; Muh, JP; Sauvage, D, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (68.29) | 18.7374 |
| 1990's | 8 (19.51) | 18.2507 |
| 2000's | 2 (4.88) | 29.6817 |
| 2010's | 3 (7.32) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| de Theije, CG | 1 |
| Wu, J | 1 |
| Koelink, PJ | 1 |
| Korte-Bouws, GA | 1 |
| Borre, Y | 1 |
| Kas, MJ | 1 |
| Lopes da Silva, S | 1 |
| Korte, SM | 1 |
| Olivier, B | 1 |
| Garssen, J | 1 |
| Kraneveld, AD | 1 |
| Horvath, GA | 1 |
| Demos, M | 1 |
| Shyr, C | 1 |
| Matthews, A | 1 |
| Zhang, L | 1 |
| Race, S | 1 |
| Stockler-Ipsiroglu, S | 1 |
| Van Allen, MI | 1 |
| Mancarci, O | 1 |
| Toker, L | 1 |
| Pavlidis, P | 1 |
| Ross, CJ | 1 |
| Wasserman, WW | 1 |
| Trump, N | 1 |
| Heales, S | 1 |
| Pope, S | 1 |
| Cross, JH | 1 |
| van Karnebeek, CD | 1 |
| Kałuzna-Czaplińska, J | 1 |
| Socha, E | 1 |
| Rynkowski, J | 1 |
| Toda, Y | 2 |
| Mori, K | 2 |
| Hashimoto, T | 2 |
| Miyazaki, M | 2 |
| Kuroda, Y | 2 |
| Nozaki, S | 1 |
| Watanabe, Y | 2 |
| Kagami, S | 1 |
| Leckman, JF | 1 |
| Cohen, DJ | 6 |
| Shaywitz, BA | 4 |
| Caparulo, BK | 2 |
| Heninger, GR | 1 |
| Bowers, MB | 2 |
| Winsberg, BG | 1 |
| Sverd, J | 1 |
| Castells, S | 1 |
| Hurwic, M | 1 |
| Perel, JM | 1 |
| Young, JG | 2 |
| Kavanagh, ME | 1 |
| Anderson, GM | 2 |
| Gillberg, C | 4 |
| Svennerholm, L | 2 |
| Hamilton-Hellberg, C | 1 |
| Martineau, J | 11 |
| Barthelemy, C | 16 |
| Garreau, B | 12 |
| Tanguay, P | 1 |
| Bruneau, N | 7 |
| Lelord, G | 18 |
| Callaway, E | 3 |
| Muh, JP | 9 |
| Lowe, TL | 1 |
| Miller, S | 1 |
| Komori, H | 1 |
| Matsuishi, T | 1 |
| Yamada, S | 1 |
| Yamashita, Y | 1 |
| Ohtaki, E | 1 |
| Kato, H | 1 |
| Hameury, L | 1 |
| Roux, S | 2 |
| Adrien, JL | 1 |
| Desombre, H | 1 |
| Sauvage, D | 2 |
| Tani, Y | 1 |
| Fernell, E | 1 |
| Kanai, T | 1 |
| Långström, B | 1 |
| Akefeldt, A | 1 |
| Ekman, R | 1 |
| Månsson, JE | 1 |
| Arlot, JC | 1 |
| Domenech, J | 1 |
| Ritvo, ER | 1 |
| Jouve, J | 5 |
| Oades, RD | 1 |
| Stern, LM | 1 |
| Walker, MK | 1 |
| Clark, CR | 1 |
| Kapoor, V | 1 |
| Zoghbi, HY | 1 |
| Percy, AK | 1 |
| Glaze, DG | 1 |
| Butler, IJ | 1 |
| Riccardi, VM | 1 |
| Launay, JM | 1 |
| Ferrari, P | 1 |
| Haimart, M | 1 |
| Bursztejn, C | 1 |
| Tabuteau, F | 1 |
| Braconnier, A | 1 |
| Pasques-Bondoux, D | 1 |
| Luong, C | 1 |
| Dreux, C | 1 |
| Minderaa, RB | 1 |
| Volkmar, FR | 1 |
| Akkerhuis, GW | 1 |
| Cheliakine, C | 1 |
| Cottet-Eymard, JM | 1 |
| Domenech-Jouve, J | 1 |
| Peyrin, L | 1 |
| Garnier, C | 1 |
| Comoy, E | 1 |
| Leddet, I | 1 |
| Johnson, WT | 1 |
| Bowers, M | 1 |
| Mrochek, JE | 1 |
| Dinsmore, SR | 1 |
| Ohrt, DW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT00004325] | 200 participants | Observational | 1988-12-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for homovanillic acid and Autism
| Article | Year |
|---|---|
Clinical neurochemistry of autism and associated disorders.
Topics: Amines; Animals; Autistic Disorder; Blood Platelets; Brain Chemistry; Catecholamines; Dopamine; Dopa | 1982 |
[Significance of clinical and biological markers in autistic syndromes in children].
Topics: Autistic Disorder; Child; Child Behavior; Child, Preschool; Dopamine; Electroencephalography; Evoked | 1987 |
6 trials available for homovanillic acid and Autism
| Article | Year |
|---|---|
Administration of secretin for autism alters dopamine metabolism in the central nervous system.
Topics: Autistic Disorder; Biopterins; Central Nervous System; Child; Child, Preschool; Dopamine; Female; Ho | 2006 |
Clinical and biological effects of high doses of vitamin B6 and magnesium on autistic children.
Topics: Adolescent; Autistic Disorder; Child; Child, Preschool; Double-Blind Method; Drug Therapy, Combinati | 1982 |
Event-related potentials and monoamines in autistic children on a clinical trial of fenfluramine.
Topics: Adolescent; Attention; Autistic Disorder; Biogenic Monoamines; Child; Double-Blind Method; Electroen | 1990 |
Auditory evoked potential modifications according to clinical and biochemical responsiveness to fenfluramine treatment in children with autistic behavior.
Topics: 3,4-Dihydroxyphenylacetic Acid; Autistic Disorder; Child; Child, Preschool; Dopamine; Evoked Potenti | 1989 |
Urinary dopamine metabolites as indicators of the responsiveness to fenfluramine treatment in children with autistic behavior.
Topics: 3,4-Dihydroxyphenylacetic Acid; Autistic Disorder; Child; Child, Preschool; Dopamine; Double-Blind M | 1989 |
Vitamin B6, magnesium, and combined B6-Mg: therapeutic effects in childhood autism.
Topics: Autistic Disorder; Child; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; | 1985 |
33 other studies available for homovanillic acid and Autism
| Article | Year |
|---|---|
Autistic-like behavioural and neurochemical changes in a mouse model of food allergy.
Topics: Age Factors; Animals; Autistic Disorder; Biogenic Monoamines; Brain; Chromatography, High Pressure L | 2014 |
Secondary neurotransmitter deficiencies in epilepsy caused by voltage-gated sodium channelopathies: A potential treatment target?
Topics: Autistic Disorder; Channelopathies; Child; Drug Resistant Epilepsy; Epilepsy; Exome; Female; Homovan | 2016 |
Determination of homovanillic acid and vanillylmandelic acid in urine of autistic children by gas chromatography/mass spectrometry.
Topics: Autistic Disorder; Case-Control Studies; Child; Child, Preschool; Gas Chromatography-Mass Spectromet | 2010 |
[Efficacy of secretin for the treatment of autism].
Topics: Adolescent; Autistic Disorder; Child; Child, Preschool; Female; Homovanillic Acid; Humans; Hydroxyin | 2004 |
CSF monoamine metabolites in child and adult psychiatric patients. A developmental perspective.
Topics: Adolescent; Adult; Age Factors; Aged; Autistic Disorder; Bipolar Disorder; Child; Child, Preschool; | 1980 |
Estimation of monoamine and cyclic-AMP turnover and amino acid concentrations of spinal fluid in autistic children.
Topics: Amines; Amino Acids; Autistic Disorder; Child; Cyclic AMP; Dopamine; Homovanillic Acid; Humans; Hydr | 1980 |
Childhood psychosis and monoamine metabolites in spinal fluid.
Topics: Adolescent; Age Factors; Autistic Disorder; Brain Diseases; Cerebral Palsy; Child; Child, Preschool; | 1983 |
[Relation between auditory evoked potentials (presence, amplitude) during sound and light conditioning and levels of dopamine derivatives in infantile autism].
Topics: Attention Deficit Disorder with Hyperactivity; Autistic Disorder; Child; Conditioning, Psychological | 1984 |
Electrocortical activity (evoked potentials) and dopamine metabolism (homovanillic acid) in normal and emotionally disturbed children.
Topics: Autistic Disorder; Cerebral Cortex; Child; Dopamine; Evoked Potentials, Auditory; Evoked Potentials, | 1984 |
Folic acid and B12 in autism and neuropsychiatric disturbances of childhood.
Topics: Adolescent; Adult; Autistic Disorder; Child; Child, Preschool; Folic Acid; Homovanillic Acid; Humans | 1981 |
Effects of vitamin B6 on averaged evoked potentials in infantile autism.
Topics: Autistic Disorder; Child; Dopamine; Evoked Potentials; Homovanillic Acid; Humans; Pyridoxine | 1981 |
Not less likely than before that mean CSF HVA may be high in autism.
Topics: Autistic Disorder; Child; Diagnosis, Differential; Homovanillic Acid; Humans; Hydroxyindoleacetic Ac | 1993 |
Cerebrospinal fluid biopterin and biogenic amine metabolites during oral R-THBP therapy for infantile autism.
Topics: Autistic Disorder; Biopterins; Child; Child, Preschool; Female; Homovanillic Acid; Humans; Hydroxyin | 1995 |
Quantified multidimensional assessment of autism and other pervasive developmental disorders. Application for bioclinical research.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adolescent; Autistic Disorder; Brain; Child; Child Development Disor | 1995 |
Decrease in 6R-5,6,7,8-tetrahydrobiopterin content in cerebrospinal fluid of autistic patients.
Topics: Adolescent; Adult; Aging; Autistic Disorder; Biopterins; Child; Child, Preschool; Female; Homovanill | 1994 |
Cerebrospinal fluid monoamines in Prader-Willi syndrome.
Topics: Adolescent; Adult; Age Factors; Autistic Disorder; Birth Weight; Body Mass Index; Child; Child, Pres | 1998 |
[Modifications in urinary homovanillic acid after ingestion of vitamin B6; functional study in autistic children (author's transl)].
Topics: Autistic Disorder; Child; Dopamine; Female; Homovanillic Acid; Humans; Male; Phenylacetates; Pyridox | 1978 |
Dopamine and serotonin metabolism in neuropsychiatrically disturbed children. CSF homovanillic acid and 5-hydroxyindoleacetic acid.
Topics: Adolescent; Age Factors; Aphasia; Attention Deficit Disorder with Hyperactivity; Autistic Disorder; | 1977 |
Biochemical studies of children with the syndromes of autism, childhood schizophrenia and related developmental disabilities: a review.
Topics: Autistic Disorder; Blood Platelets; Brain; Bufotenin; Child; Dopamine beta-Hydroxylase; Homovanillic | 1977 |
Monoamines (serotonin and catecholamines) and their derivatives in infantile autism: age-related changes and drug effects.
Topics: 3,4-Dihydroxyphenylacetic Acid; Age Factors; Autistic Disorder; Catecholamines; Child; Child Develop | 1992 |
[Development in the metabolism of dopamine and its derivatives. Application to gross development disorders].
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Analysis of Variance; Autistic Disorder; Child; Child, Presch | 1992 |
Reduction of biogenic amine levels in the Rett syndrome.
Topics: Adolescent; Ataxia; Autistic Disorder; Biogenic Amines; Child; Child, Preschool; Dementia; Electroen | 1985 |
CSF monoamines in autistic syndromes and other pervasive developmental disorders of early childhood.
Topics: Adolescent; Autistic Disorder; Child; Child Development Disorders, Pervasive; Child, Preschool; Fema | 1987 |
Serotonin metabolism and other biochemical parameters in infantile autism. A controlled study of 22 autistic children.
Topics: Adolescent; Autistic Disorder; Blood Platelets; Child; Child, Preschool; Female; Glutathione Peroxid | 1988 |
Neurochemical study of dopamine functioning in autistic and normal subjects.
Topics: Adolescent; Adult; Autistic Disorder; Dopamine; Female; Homovanillic Acid; Humans; Male; Phenothiazi | 1989 |
Long-term effects of combined vitamin B6-magnesium administration in an autistic child.
Topics: Autistic Disorder; Child, Preschool; Drug Therapy, Combination; Evoked Potentials, Auditory; Homovan | 1986 |
Brief report: an open middle-term study of combined vitamin B6-magnesium in a subgroup of autistic children selected on their sensitivity to this treatment.
Topics: Autistic Disorder; Child; Child, Preschool; Dopamine; Drug Therapy, Combination; Evoked Potentials, | 1988 |
Urinary free and conjugated catecholamines and metabolites in autistic children.
Topics: 3,4-Dihydroxyphenylacetic Acid; Autistic Disorder; Catecholamines; Child; Child, Preschool; Dopamine | 1988 |
Urinary homovanillic acid levels of autistic children.
Topics: Autistic Disorder; Child; Child, Preschool; Female; Homovanillic Acid; Humans; Intellectual Disabili | 1988 |
Developmental changes in ERPs and monoamine metabolites in normal, mentally retarded and autistic children.
Topics: Autistic Disorder; Child; Child Development; Child, Preschool; Evoked Potentials, Auditory; Homovani | 1987 |
Dopamine-beta-hydroxylase (DBH) and homovanillic acid (HVA) in autistic children.
Topics: Age Factors; Autistic Disorder; Brain Chemistry; Catecholamines; Child; Child, Preschool; Dopamine b | 1986 |
Biogenic amines in autistic and atypical children. Cerebrospinal fluid measures of homovanillic acid and 5-hydroxyindoleacetic acid.
Topics: Autistic Disorder; Brain; Child; Child, Preschool; Diagnosis, Differential; Dopamine; Electroencepha | 1974 |
Monitoring phenylalanine-tyrosine metabolism by high-resolution liquid chromatography of urine.
Topics: Aromatic Amino Acid Decarboxylase Inhibitors; Autistic Disorder; Carbidopa; Catechols; Child; Chroma | 1973 |