homoharringtonine and Leukemia--Erythroblastic--Acute

homoharringtonine has been researched along with Leukemia--Erythroblastic--Acute* in 2 studies

Other Studies

2 other study(ies) available for homoharringtonine and Leukemia--Erythroblastic--Acute

Article	Year
[2 homoharringtonine resistant leukemic cell lines (K562 HHT and L1210 HHT): establishment, characterization and mechanisms of action]. Zhonghua yi xue za zhi, 1994, Volume: 74, Issue:7 We developed two leukemic cell lines (K562 HHT and L1210 HHT) stably 16.7 fold and 13.4 fold resistant to HHT respectively with which the culture were treated. Both cell lines were also cross-resistant to DOX, VCR, DNR and Mel. Increased expression of MDR1 gene in the both lines was noted. To further evaluate the implications of MDR1 in HHT resistance. We studied the expression of MDR1 in sensitive and HHT-resistant sublines of K562 by ABC with an monoclonal antibody against P170, JSB-1. K562 HHT cells were positive but sensitive cells were negative. Additionally, the increased drug resistance was associated with increased level of expression of alpha and pi class GST gene, but not with increased level of expression of mu class GST gene. Topics: Animals; Antineoplastic Agents, Phytogenic; Drug Resistance; Harringtonines; Homoharringtonine; Humans; Leukemia L1210; Leukemia, Erythroblastic, Acute; Tumor Cells, Cultured	1994
The influence of several anticancer agents on cell proliferation, differentiation and the cell cycle of murine erythroleukemia cells. The American journal of Chinese medicine, 1981,Winter, Volume: 9, Issue:4 The influence of homoharringtonine, hydroxycamptothecin and lycobetaine on the cell cycle progression of murine erythroleukemia cells was studied by using flow microfluorometry (FMF) technique and centrifugal elutriation to obtain specific fractions of the cell cycle. FMF histogram analysis showed that homoharringtonine could strongly arrest cells in the G1 phase of the immediate cell cycle. This effect was more pronounced and persisted longer with G1 cells than with S or G2 cells. Hydroxycamptothecin mainly delayed the progression of S cells of the subsequent cell cycle (daughter cells). Lycobetaine caused a marked accumulation of G2 cells. These 3 compounds possess a relatively specific action on cell progression through the cell cycle. Homoharringtonine and hydroxycamptothecin can inhibit the cell proliferation of murine erythroleukemia cells (MELC) at low concentrations (ng/ml) whereas lycobetaine, cantharidin and oxalysine are less potent. Among them only hydroxycamptothecin had a weak activity to induce MELC differentiation. These results may provide some basic knowledge for designing new protocols of the combination treatment of neoplastic diseases. Topics: Alkaloids; Amaryllidaceae Alkaloids; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Camptothecin; Cell Cycle; Cell Differentiation; Cell Division; Cell Separation; Cells, Cultured; Flow Cytometry; Harringtonines; Homoharringtonine; Indolizines; Leukemia, Erythroblastic, Acute; Mice	1981

Article

Year

[2 homoharringtonine resistant leukemic cell lines (K562 HHT and L1210 HHT): establishment, characterization and mechanisms of action].

Zhonghua yi xue za zhi, 1994, Volume: 74, Issue:7

We developed two leukemic cell lines (K562 HHT and L1210 HHT) stably 16.7 fold and 13.4 fold resistant to HHT respectively with which the culture were treated. Both cell lines were also cross-resistant to DOX, VCR, DNR and Mel. Increased expression of MDR1 gene in the both lines was noted. To further evaluate the implications of MDR1 in HHT resistance. We studied the expression of MDR1 in sensitive and HHT-resistant sublines of K562 by ABC with an monoclonal antibody against P170, JSB-1. K562 HHT cells were positive but sensitive cells were negative. Additionally, the increased drug resistance was associated with increased level of expression of alpha and pi class GST gene, but not with increased level of expression of mu class GST gene.

Topics: Animals; Antineoplastic Agents, Phytogenic; Drug Resistance; Harringtonines; Homoharringtonine; Humans; Leukemia L1210; Leukemia, Erythroblastic, Acute; Tumor Cells, Cultured

1994

The influence of several anticancer agents on cell proliferation, differentiation and the cell cycle of murine erythroleukemia cells.

The American journal of Chinese medicine, 1981,Winter, Volume: 9, Issue:4

The influence of homoharringtonine, hydroxycamptothecin and lycobetaine on the cell cycle progression of murine erythroleukemia cells was studied by using flow microfluorometry (FMF) technique and centrifugal elutriation to obtain specific fractions of the cell cycle. FMF histogram analysis showed that homoharringtonine could strongly arrest cells in the G1 phase of the immediate cell cycle. This effect was more pronounced and persisted longer with G1 cells than with S or G2 cells. Hydroxycamptothecin mainly delayed the progression of S cells of the subsequent cell cycle (daughter cells). Lycobetaine caused a marked accumulation of G2 cells. These 3 compounds possess a relatively specific action on cell progression through the cell cycle. Homoharringtonine and hydroxycamptothecin can inhibit the cell proliferation of murine erythroleukemia cells (MELC) at low concentrations (ng/ml) whereas lycobetaine, cantharidin and oxalysine are less potent. Among them only hydroxycamptothecin had a weak activity to induce MELC differentiation. These results may provide some basic knowledge for designing new protocols of the combination treatment of neoplastic diseases.

Topics: Alkaloids; Amaryllidaceae Alkaloids; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Camptothecin; Cell Cycle; Cell Differentiation; Cell Division; Cell Separation; Cells, Cultured; Flow Cytometry; Harringtonines; Homoharringtonine; Indolizines; Leukemia, Erythroblastic, Acute; Mice

1981