homoharringtonine and Glaucoma--Angle-Closure

To prevent the cicatrization of filtering blebs after glaucoma filtering surgery, subconjunctival injections of low dosage homoharringtonine were administered to 22 glaucomatous eyes (20 patients) postoperatively. The percentage of functional filtering blebs was 90.9% and the mean postoperative IOP was 2.04 +/- 0.68 kPa (1 kPa = 7.5 mmHg). In comparison with the control group, the differences were very significant (P < or = 0.01). The results suggest that the toxicity of low dosage of homoharringtonine be very low, it inhibit fibroblast proliferation and play important roles in the formation of the functional filtering blebs and elevation of the success rate of filtration operation.

Topics: Adult; Aged; Antimetabolites; Cicatrix; Female; Filtering Surgery; Follow-Up Studies; Glaucoma, Angle-Closure; Harringtonines; Homoharringtonine; Humans; Male; Middle Aged